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Biological targets of isothiocyanates
Biochimica et Biophysica Acta (BBA) - General Subjects, 2011Isothiocyanates are phytochemicals with a broad array of effects in biological systems. Bioactivity includes the stimulation of cellular antioxidant systems, induction of apoptosis and interference with cytokine production and activity. Epidemiological evidence and experimental studies indicate that naturally occurring isothiocyanates and synthetic ...
Kristin K, Brown, Mark B, Hampton
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Inhibition of papain by isothiocyanates
Biochimica et Biophysica Acta (BBA) - Enzymology, 1976During the tapping of papaya latex for papain (EC 3.4.22.2), benzyl isothiocyanate is enzymatically produced from benzylglucosinolate, a major component of the latex fluid. Benzyl isothiocyanate inhibits papain hydrolysis of alpha-N-benzoyl-L-arginine ethyl ester (Bz-Arg-OEt).
C S, Tang, W J, Tang
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Pharmacokinetics and pharmacodynamics of isothiocyanates
Drug Metabolism Reviews, 2011Isothiocyanates from Brassica vegetables are of great interest for use in the cure of bacterial infections, as is their potential application in the prevention and treatment of cancer. Although much information is available on their mode of action within the cell, when it comes to the question of whether the necessary pharmacologic concentration has ...
Lamy, Evelyn +3 more
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Tetraalkylammonium Uranyl Isothiocyanates
Inorganic Chemistry, 2012Three tetraalkylammonium uranyl isothiocyanates, [(CH(3))(4)N](3)UO(2)(NCS)(5) (1), [(C(2)H(5))(4)N](3)UO(2)(NCS)(5) (2), and [(C(3)H(7))(4)N](3)UO(2)(NCS)(5) (3), have been synthesized from aqueous solution and their structures determined by single-crystal X-ray diffraction. All of the compounds consist of the uranyl cation equatorially coordinated to
Clare E, Rowland +2 more
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Structure of isothiocyanate methemoglobin
Journal of Molecular Biology, 1981Abstract The structure of the complex of the ambidentate ligand thiocyanate with horse methemoglobin was compared with that of acid methemoglobin and azide methemoglobin by X-ray difference Fourier techniques. Thiocyanate is co-ordinated to iron exclusively by its nitrogen atom, and thus forms the isothiocyanate complex.
Z R, Korszun, K, Moffat
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INHIBITION OF CARCINOGENESIS BY ISOTHIOCYANATES*
Drug Metabolism Reviews, 2000Isothiocyanates occur as conjugates in a wide variety of cruciferous vegetables. Consumption of normal amounts of these vegetables results in the uptake of substantial quantities of isothiocyanates. These naturally occurring isothiocyanates as well as many synthetic analogs can be powerful inhibitors of carcinogenesis in laboratory animals ...
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Genotoxic effects of allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC)
Chemico-Biological Interactions, 2000Two isothiocyanates (ITCs) commonly found in human diet, allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC), were tested for genotoxic effects in a battery of assays: Salmonella/microsome assay with TA 98 and TA 100, differential DNA repair assay with E. coli and micronucleus (MN) induction assay with human derived Hep G2 cells. Albeit to
F, Kassie, S, Knasmüller
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Isothiocyanates of natural derivation
Pure and Applied Chemistry, 1963Abstract
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Isothiocyanates by Substitution Reactions of Isothiocyanates
2005S. Braverman, M. Cherkinsky, M. L. Birsa
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