Results 201 to 210 of about 12,031 (303)

Network pharmacology refined with non-ubiquity and decoy-controlled molecular docking reveals insights into <i>Moringa oleifera</i> phytochemicals targeting insulin resistance. [PDF]

Front Bioinform
Santos-Enriquez AK, Dayrit FM, de Jesus AJ, Rojas NRL.   +3 more
europepmc   +1 more source

Traceable Traceless Delivery Tags

Helvetica Chimica Acta, EarlyView.
ABSTRACT This study elaborates on traceless tags for the thiol‐mediated uptake (TMU) of amine‐containing substrates of interest (SOIs). Traceless tags typically contain linkers that can be enzymatically cleaved to trigger the release of SOIs in their native form.
Julia Moreno, Xudong Ren, Saidbakhrom Saidjalolov, Pierre Josso, Naomi Sakai, Stefan Matile   +5 more
wiley   +1 more source

Structural Elucidation and Storage Stability of Novel Dietary Sulfur Compounds from Radish. [PDF]

Foods
Jeong GA, Lee I, Sung J, Lee CJ.
europepmc   +1 more source

Beyond “you are what you eat”: Unlocking gut microbiota‐mediated biotransformation of dietary phytochemicals

iMetaOmics, EarlyView.
The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley   +1 more source

Natural Anti-Inflammatory Agents in the Chemoprevention of Gliomas: Targeting Neuroinflammation and the Tumor Microenvironment. [PDF]

Cancers (Basel)
Markopoulos GS, Sioka C, Alexiou GA, Peschos D, Vartholomatos G, Kyritsis AP.   +5 more
europepmc   +1 more source

Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome

iMetaOmics, EarlyView.
A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo, Huacheng Wang, Meili Gao, Chao Qin, Ke Zhu, Yun Leng, Kamran Ullah, Jun Liang, Haiyan Yan, Guan Yang, Yingqian Mo, Bihui Huang   +20 more
wiley   +1 more source

The Enigma of Sponge-Derived Terpenoid Isothiocyanate-Thiocyanate Pairs: A Biosynthetic Proposal. [PDF]

Mar Drugs
Molinski TF.
europepmc   +1 more source

Targeting Renal IGFBP7 With Tetrahedral Framework Nucleic Acid‐Delivered siRNA Alleviates Acute Kidney Injury

iNew Medicine, EarlyView.
A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted therapies remain ...
Shao‐qi Wu, Ying‐ying Gao, Meng‐yi Jia, Yu‐Hao Liu, Qian Zhou, Dong Liu, Yu Ren, Yu‐jie Liu, Feng‐he Li, Ya‐ru Yang, Jie Wang, Jia‐gen Wen   +11 more
wiley   +1 more source

Design and Application of a Phenanthroline-Based Covalent Triazine Framework with Cu(I) for the Heterogeneous Synthesis of 2-Aminobenzothiazoles. [PDF]

ACS Appl Mater Interfaces
Vega J, Capitan MJ, Alonso JA, Fraile A, Alemán J.   +4 more
europepmc   +1 more source