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Chemoprevention by isothiocyanates

Journal of Cellular Biochemistry, 1995
Naturally occurring and synthetic isothiocyanates are among the most effective chemopreventive agents known. A wide variety of isothiocyanates prevents cancer in the rat lung, mammary gland, esophagus, liver, small intestine, colon, and bladder. Mechanistic studies have shown that this chemopreventive activity is due to favorable modification of phase ...
Stephen Hecht
exaly   +3 more sources

INHIBITION OF CARCINOGENESIS BY ISOTHIOCYANATES*

Drug Metabolism Reviews, 2000
Isothiocyanates occur as conjugates in a wide variety of cruciferous vegetables. Consumption of normal amounts of these vegetables results in the uptake of substantial quantities of isothiocyanates. These naturally occurring isothiocyanates as well as many synthetic analogs can be powerful inhibitors of carcinogenesis in laboratory animals ...
Stephen Hecht
exaly   +3 more sources

Isothiocyanates in Cancer Prevention

Drug Metabolism Reviews, 2004
Isothiocyanates are sulfur-containing compounds which are largely responsible for the typical flavor of cruciferous vegetables. In animals and humans they are conjugated with glutathione; the first product of this reaction is a dithiocarbamate, which can be ultimately metabolized to the corresponding mercapturic acid, excreted in urine.
Franca, Bianchini, Harri, Vainio
exaly   +3 more sources

A Convenient Synthesis of Tertiary Isothiocyanates and Acyl Isothiocyanates Using Phosphoryl Isothiocyanate

Synthetic Communications, 1990
Abstract Phosphoryl isothiocyanate, PO(NCS)3, reacts readily with tertiary alcohols and carboxylic acids, giving the respective tertiary isothiocyanates and acyl isothiocyanates in good yields and purity.
Ladislav Kniežo, Juraj Bernát
openaire   +1 more source

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