Results 221 to 230 of about 57,431 (346)

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

open access: yesPhytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek   +3 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao   +4 more
wiley   +1 more source

Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito   +6 more
wiley   +1 more source

Transport engineering as a strategy to realize rapeseed's potential as a protein‐rich food

open access: yesPest Management Science, EarlyView.
The heavily pesticide‐dependent rapeseed is an under‐utilized protein source for food owing to anti‐nutritional glucosinolates. Transport engineering technology may reduce glucosinolates in seeds while increasing defense in vegetative parts. Abstract Rapeseed is the world's second‐largest oilseed crop, and the low‐value press cake that remains after ...
Jakob Skytte Thorsen   +2 more
wiley   +1 more source

Field investigation of glucosinolates and morphological traits in mitigating Psylliodes chrysocephala larval infestation through crop varieties and companion planting

open access: yesPest Management Science, EarlyView.
Genotype and cropping system influenced oilseed rape ecophysiological traits, including glucosinolate compounds (glucoraphanin, glucobrassicanapin, and butyl‐glucosinolates) and biomass, which were linked to Psylliodes chrysocephala larval infestation, with varietal effects stronger than faba bean companion planting.
Laurie Magnin   +4 more
wiley   +1 more source

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