Results 121 to 130 of about 27,457 (208)

Predicting Diabetic Foot Ulcer Outcomes: Machine Learning‐Based Refinement of IWGDF‐Approved Classifications for Outpatient Services

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Six IWGDF‐approved diabetic foot ulcer classification systems were compared using machine‐learning models. SINBAD and UTWCS showed the strongest prediction of poor outcomes, while a modified WIFI system using simplified wound‐depth grading further improved predictive performance in outpatient care. ABSTRACT Introduction This study aimed to validate and
Farideh Mostafavi, Mohammad Reza Amini, Yadollah Mehrabi, Melina Rezvani, Mehrangiz Toutounchi, Seyed Saeed Hashemi Nazari   +5 more
wiley   +1 more source

Extracellular Vesicles in Osteoarthritis: From Pathogenic Mediators to Engineered Therapeutics in a Precision Medicine Roadmap

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Osteoarthritis (OA) remains without disease‐modifying sssstherapies, in part due to biological heterogeneity and a hostile joint microenvironment that undermines one‐size‐fits‐all interventions. Extracellular vesicles (EVs) play a dual role in OA pathophysiology: endogenous EVs disseminate pro‐inflammatory and catabolic signals that propagate ...
Duc‐Hiep Bach, Van Giang Bui, Thanh Liem Nguyen   +2 more
wiley   +1 more source

Orbital Complications of Acute Rhinosinusitis in Adulthood: Predictors of Outcome and Management

The Laryngoscope, Volume 136, Issue 5, Page 2073-2081, May 2026.
In a multicenter cohort of 213 adults with orbital complications of acute rhinosinusitis, 68% required surgery and the modified Chandler classification was the strongest predictor of treatment modality. While abscess‐related and type II complications frequently necessitated surgical management, final ophthalmologic outcomes were uniformly favorable ...
Alessandro Vinciguerra, Vittorio Rampinelli, Mario Turri‐Zanoni, Marco Ferrari, Marco Valentini, Alberto Daniele Arosio, Federico Raimondi, Florian Chatelet, Stefano Taboni, Davide Mattavelli, Alberto Schreiber, Fabio Sovardi, Matteo Barucco, Lorena Di Girolami, Piergiorgio Gaudioso, Antonio Daloiso, Giulia Danè, Umberto Tanzini, Nicola Tessari, Jessica Zuppardo, Kays Burak Cakir, Yetkin Zeki Yilmaz, Yasar Unlu, Andrea Ronchi, Stefania Gallo, Francesca De Bernardi, Vasileios Chatzinakis, Argyro Leventi, Fabio Pagella, Benjamin Verillaud, Giuseppe Mercante, Apostolos Karligkiotis, Mario Bussi, Cesare Piazza, Alperen Vural, Paolo Castelnuovo, Piero Nicolai, Maurizio Bignami, Christos Georgalas, Iacopo Dallan, Philippe Herman, Paolo Battaglia   +41 more
wiley   +1 more source

A Dose‐Finding Design for Drug Combinations Using a Bayesian 4 Parameter Logistic Model With Penalised D‐Optimality

Pharmaceutical Statistics, Volume 25, Issue 3, May/June 2026.
ABSTRACT Drug combinations, where two drugs are co‐administered, are being explored widely within Phase I trials in oncology. These trials aim to identify the maximum tolerated dose combination (MTDC) by adapting the dose of both treatments based on current trial data.
Maxine Ajimi, Benjamin Webb, Graham M. Wheeler, Jayne Marshall, Adrian P. Mander   +4 more
wiley   +1 more source

Electromyography and sonomyography analysis of the tibialis anterior: a cross sectional study

Journal of Foot and Ankle Research, 2014
Background Foot dorsiflexion plays an essential role in both controlling balance and human gait. Electromyography (EMG) and sonomyography (SMG) can provide information on several aspects of muscle function.
Maria Ruiz‐Muñoz, Antonio I Cuesta‐Vargas   +1 more
doaj   +1 more source

Surgical management of an open humeral fracture in a greater rhea (Rhea americana): Internal placement of a locking compression plate and post‐operative complications

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
SUMMARY A 17‐year‐old, 24‐kg, female greater rhea (Rhea americana) presented with an acute onset of left wing droop. Clinical examination and radiographs revealed an open, simple, displaced, short‐oblique diaphyseal fracture of the distal third of the left humerus.
Pierre Huberdeau, Thomas Coutant, Aram Arslanian, Emeline Maurice, Fouad Stephan, Sylvie Laidebeure, Alexis Lécu   +6 more
wiley   +1 more source

Machine learning algorithms for prediction of cerebrospinal fluid leakage after posterior surgery for thoracic ossification of the ligamentum flavum

Scientific Reports
To develop and validate a machine-learning (ML) model that pre-operatively predicts cerebrospinal-fluid leakage (CSFL) after posterior decompression for thoracic ossification of the ligamentum flavum (TOLF), and to elucidate the key risk factors driving ...
Ruizhou Guo, Ben Liu, Yunqi Wu, Yilu Zhang, Xiyang Wang, Dingyu Jiang, Zheng Liu   +6 more
doaj   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, Volume 183, Issue 10, Page 2518-2532, May 2026.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Safety of [68Ga]Ga‐FAPI‐46 PET/CT including hemodynamic measurements and patient‐reported outcomes in cancer patients

Clinical Physiology and Functional Imaging, Volume 46, Issue 3, May 2026.
Abstract Introduction Aim Fibroblast activation protein inhibitor (FAPI) has demonstrated promising oncological diagnostic performance. Although no adverse events (AEs) have been previously reported, a formal safety evaluation of FAPI PET/CT is lacking.
Morten Bentestuen, Camilla Sylvest, Svend B. Jensen, Lara R. Soro, Aage Knudsen, Morten Ladekarl, Ole Thorlacius‐Ussing, Wolfgang P. Fendler, Helle D. Zacho   +8 more
wiley   +1 more source

Effects of different bupivacaine injection speeds on hemodynamic and some other parameters during spinal anesthesia for cesarean section

Medicine Science
Bupivacaine-induced spinal anesthesia is the most commonly used method for cesarean section. However, maternal hypotension may develop as a significant side effect.
Zeliha Korkmaz Disli, Hulya Gundogdu, Leman Acun Delen   +2 more
doaj   +1 more source