Results 1 to 10 of about 9,554,450 (161)

A new ‘biased coin design’ for the sequential allocation of two treatments

Journal of the Royal Statistical Society Series C: Applied Statistics, 2004
SummaryEfron’s biased coin design is a well-known randomization technique that helps to neutralize selection bias in sequential clinical trials for comparing treatments, while keeping the experiment fairly balanced. Extensions of the biased coin design have been proposed by several researchers who have focused mainly on the large sample properties of ...
Alessandro Baldi Antognini
exaly   +8 more sources

Determining the Minimum Effective Concentration of Ropivacaine in Epidural Anesthesia for Tolerable Pain in Transforaminal Percutaneous Endoscopic Lumbar Discectomy to Avoid Nerve Injury: A Double-Blind Study Using a Biased-Coin Design [PDF]

Drug Design, Development and Therapy, 2022
Bingwei Hu,1,2 Liang Li,2 Hongwei Wang,2 Tingting Ma,2 Zhimei Fu,2 Xianhui Kang,3 Zhiying Feng1 1Department of Pain, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Department of ...
Hu B, Li L, Wang H, Ma T, Fu Z, Kang X, Feng Z   +6 more
doaj   +2 more sources

Effective dose of ciprofol combined with low-dose sufentanil for sedation of gastroscopy: a dose-finding study using a biased coin design [PDF]

BMC Anesthesiology
Objective This study aimed to determine the 90% effective dose of ciprofol combined with 5 µg of sufentanil for sedation during gastroscopy. Methods This was a double-blind, single-center dose-finding study.
Bingwei Hu, Ting Guan, Chenyuan Yu, Danfeng Wang, Qing Wang, Hongwei Wang   +5 more
doaj   +2 more sources

Minimum Effective Concentration of Ropivacaine for Ultrasound-Guided RISS Block in VATS: A Biased Coin Design Approach [PDF]

Drug Design, Development and Therapy
Ping Li,1,2 Zhongsai Yang,1,3 Long Zhang,4 Ruilan Wu,2 Manhua Zhu,2 Junran Xie1 1Department of Anesthesiology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, Zhejiang Province, 310016, People’s Republic of China; 2Department ...
Li P, Yang Z, Zhang L, Wu R, Zhu M, Xie J   +5 more
doaj   +2 more sources

ED90 of intravenous remimazolam for alleviating preoperative anxiety in children: a prospective dose-finding study [PDF]

Frontiers in Medicine
BackgroundChildren’s minds are immature, making them more susceptible to severe anxiety when separated from their parents before surgery. Alleviating preoperative anxiety in children is essential for providing comfort-oriented healthcare.
Xu-ming Zhu, Xiao-yong Wei, Qian-yu Guo, Pei-pei Hao, Le-ting Ji, Chang-sheng Li   +5 more
doaj   +2 more sources

Determination of the 90% effective dose of propofol combined with oliceridine or fentanyl for inhibiting the insertion response in upper gastrointestinal endoscopy: a dose-finding trial [PDF]

Frontiers in Medicine
BackgroundPropofol combined with opioids is commonly used for procedural sedation, enhancing patient tolerance and reducing the incidence of adverse events. This study aimed to determine the 90% effective dose (ED90) of propofol combined with fentanyl or
Fangsheng Xu, Yuanyuan Cui, Ye Huang, Jian Tang, Yuan Xu, Mingcong Wang, Mengqi Liu, Kehui Qu, Jianfeng Pu, Meifang Wang, Qian Wang   +10 more
doaj   +2 more sources

The Optimal Effective Concentration of Spinal Anesthesia for Interlaminar Endoscopic Lumbar Discectomy: An Approach Based on the Biased Coin Design [PDF]

Drug Design, Development and Therapy
Long Zhang,1,2,* Yu Zhang,1,2,* Ping Li,3 Bingwei Hu,4 Guanyi Liu,2,5 Miao Zhu,1,2 Liyong Yuan,1,2 Yaqing Xu1,2 1Department of Anesthesiology, Ningbo No.6 Hospital, Ningbo, Zhejiang, People’s Republic of China; 2Ningbo Clinical Research ...
Zhang L, Zhang Y, Li P, Hu B, Liu G, Zhu M, Yuan L, Xu Y   +7 more
doaj   +2 more sources

Optimal dose of ciprofol combined with remifentanil for laryngeal mask placement without muscle relaxant: a biased-coin up-and-down sequential allocation trial [PDF]

BMC Anesthesiology
Objective To determine the effective dose of ciprofol in combination with remifentanil for successful laryngeal mask airway (LMA) placement without the use of muscle relaxants.
Xiaojian Lu, Hongwei Wang, Chenrong Bao, Ying Wang, Yan Luo   +4 more
doaj   +2 more sources

Pharmacodynamics study of remimazolam besylate in anxious patients undergoing gastroscopy: a biased-coin design up-and-down sequential allocation trial [PDF]

BMC Anesthesiology
Background This study aimed to evaluate the impact of anxiety on the pharmacodynamics of remimazolam besylate in patients undergoing gastroscopy. Methods Patients undergoing gastroscopy were divided into two groups: an anxiety group (Self -rating Anxiety
Bao-Zhu Cha, Shuang-Yan Hu, Nian-Ping Chen, Jia-Fei Cao, Cheng Xu, Kai Qiu, Foquan Luo   +6 more
doaj   +2 more sources

Minimum effective concentration of ropivacaine for ultrasound-guided pericapsular nerve group block to relieve spinal anesthesia positioning pain in elderly patients with femoral intertrochanteric fracture: a double-blind biased-coin dose-finding study [PDF]

Frontiers in Medicine
BackgroundThe optimal ropivacaine concentration for ultrasound-guided pericapsular nerve group (PENG) block to relieve spinal anesthesia positioning pain in elderly patients with femoral intertrochanteric fracture remains unclear.
Wenwen Zhai, Feng Yue, Yujie Wang, Yujie Wang, Mingfeng Mao, Fenglin Guo, Fang Guo, Bo Jiang, Min Li, Min Li, Xiangyang Guo, Xiangyang Guo   +11 more
doaj   +2 more sources