Results 1 to 10 of about 5,006 (131)

Minimum Effective Concentration of Ropivacaine for Ultrasound-Guided RISS Block in VATS: A Biased Coin Design Approach [PDF]

Drug Design, Development and Therapy
Ping Li,1,2 Zhongsai Yang,1,3 Long Zhang,4 Ruilan Wu,2 Manhua Zhu,2 Junran Xie1 1Department of Anesthesiology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, Zhejiang Province, 310016, People’s Republic of China; 2Department ...
Li P, Yang Z, Zhang L, Wu R, Zhu M, Xie J   +5 more
doaj   +4 more sources

Determining the Minimum Effective Concentration of Ropivacaine in Epidural Anesthesia for Tolerable Pain in Transforaminal Percutaneous Endoscopic Lumbar Discectomy to Avoid Nerve Injury: A Double-Blind Study Using a Biased-Coin Design [PDF]

Drug Design, Development and Therapy, 2022
Bingwei Hu,1,2 Liang Li,2 Hongwei Wang,2 Tingting Ma,2 Zhimei Fu,2 Xianhui Kang,3 Zhiying Feng1 1Department of Pain, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Department of ...
Hu B, Li L, Wang H, Ma T, Fu Z, Kang X, Feng Z   +6 more
doaj   +2 more sources

Effective dose of ciprofol combined with low-dose sufentanil for sedation of gastroscopy: a dose-finding study using a biased coin design [PDF]

BMC Anesthesiology
Objective This study aimed to determine the 90% effective dose of ciprofol combined with 5 µg of sufentanil for sedation during gastroscopy. Methods This was a double-blind, single-center dose-finding study.
Bingwei Hu, Ting Guan, Chenyuan Yu, Danfeng Wang, Qing Wang, Hongwei Wang   +5 more
doaj   +2 more sources

The Adaptive Biased Coin Design for Sequential Experiments

Annals of Statistics, 1978
In comparing two treatments, eligible subjects come to the experiment sequentially and must be treated at once. To reduce experimental bias and to increase the precision of inference about treatment effects, the adaptive biased coin design, which offers a compromise between perfect balance and complete randomization, is proposed and analyzed.
L J Wei
exaly   +4 more sources

ED90 of intravenous remimazolam for alleviating preoperative anxiety in children: a prospective dose-finding study [PDF]

Frontiers in Medicine
BackgroundChildren’s minds are immature, making them more susceptible to severe anxiety when separated from their parents before surgery. Alleviating preoperative anxiety in children is essential for providing comfort-oriented healthcare.
Xu-ming Zhu, Xiao-yong Wei, Qian-yu Guo, Pei-pei Hao, Le-ting Ji, Chang-sheng Li   +5 more
doaj   +2 more sources

Determination of the 90% effective dose of propofol combined with oliceridine or fentanyl for inhibiting the insertion response in upper gastrointestinal endoscopy: a dose-finding trial [PDF]

Frontiers in Medicine
BackgroundPropofol combined with opioids is commonly used for procedural sedation, enhancing patient tolerance and reducing the incidence of adverse events. This study aimed to determine the 90% effective dose (ED90) of propofol combined with fentanyl or
Fangsheng Xu, Yuanyuan Cui, Ye Huang, Jian Tang, Yuan Xu, Mingcong Wang, Mengqi Liu, Kehui Qu, Jianfeng Pu, Meifang Wang, Qian Wang   +10 more
doaj   +2 more sources

A new 'biased coin design' for the sequential allocation of two treatments

Journal of the Royal Statistical Society Series C: Applied Statistics, 2004
SummaryEfron’s biased coin design is a well-known randomization technique that helps to neutralize selection bias in sequential clinical trials for comparing treatments, while keeping the experiment fairly balanced. Extensions of the biased coin design have been proposed by several researchers who have focused mainly on the large sample properties of ...
Alessandro Baldi Antognini
exaly   +5 more sources

Topical Airway Lidocaine Spray Reduces the 95% Effective Dose of Sufentanil for Blunting Hemodynamic Response to Tracheal Intubation in Elderly Patients: A Biased-Coin Up-and-Down Sequential Allocation Trial [PDF]

Drug Design, Development and Therapy
Xu Chen,1,* Jinjing Yang,2,* Kunyun Pan,1 Hao Wu,1 Sheng Wang,1 Wei Zhang,1 Chengwei Yang1 1Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology ...
Chen X, Yang J, Pan K, Wu H, Wang S, Zhang W, Yang C   +6 more
doaj   +2 more sources

The Optimal Effective Concentration of Spinal Anesthesia for Interlaminar Endoscopic Lumbar Discectomy: An Approach Based on the Biased Coin Design [PDF]

Drug Design, Development and Therapy
Long Zhang,1,2,* Yu Zhang,1,2,* Ping Li,3 Bingwei Hu,4 Guanyi Liu,2,5 Miao Zhu,1,2 Liyong Yuan,1,2 Yaqing Xu1,2 1Department of Anesthesiology, Ningbo No.6 Hospital, Ningbo, Zhejiang, People’s Republic of China; 2Ningbo Clinical Research ...
Zhang L, Zhang Y, Li P, Hu B, Liu G, Zhu M, Yuan L, Xu Y   +7 more
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Minimum Effective Volume of 0.25% Ropivacaine for Ultrasound-Guided Superior Trunk Block with Dexmedetomidine Sedation in Shoulder Arthroscopy: A Biased Coin Up-and-Down Trial [PDF]

Drug Design, Development and Therapy
Kai Wang,1,2,* Shuhan Zhang,1,* Zhaoyu Lv,1,* Wei Chen,1 Yonghua Li1 1Department of Anesthesiology, Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital), Shanghai, People’s Republic of China ...
Wang K, Zhang S, Lv Z, Chen W, Li Y
doaj   +2 more sources