Results 11 to 20 of about 69,041 (263)

Sequential Treatment Allocation Using Biased Coin Designs

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1984
SUMMARY Biased coin designs are used in clinical trials as a means of achieving approximate balance within a randomized design. In this paper, detailed results are obtained for a class of biased coin designs from the point of view of the degree of balance achieved, selection bias, accidental bias and inference following the randomized ...
openaire   +4 more sources

The 95% effective dose of dexmedetomidine to induce adequate sedation in patients with chronic insomnia disorder: a biased coin design up-and-down sequential allocation trial [PDF]

BMC Anesthesiology
Background Chronic insomnia disorder is a common sleep disorder. Previous studies have reported increased demand for anesthetics in patients with chronic insomnia disorder.
Mengya Li, Guifeng Li, Qifang Li, Qing Cai   +3 more
doaj   +2 more sources

Determination of ED90 and ED99 of Oliceridine combined with Propofol in inhibiting responses to gastroscope insertion: a biased coin up-and-down design [PDF]

BMC Anesthesiology
Background Gastroscopy is a common medical procedure, but the insertion of the endoscope often causes significant discomfort and anxiety in patients, necessitating effective sedation strategies.
Zhiyong Tang, Guangfen Yin, Yaohan Yu, Yinghong Luo, Shuqin Tian, Qingdong Zhang, Yanwei Fang, Qinghang Xuan   +7 more
doaj   +2 more sources

The 90% effective dose (ED90) of esketamine for inhibiting responses to intraoperative motor stimulation during ambulatory hysteroscopy: a biased-coin up-and-down sequential allocation trial [PDF]

BMC Anesthesiology
Background Esketamine and remimazolam co-administration presents a viable opioid-free anesthetic alternative for outpatient hysteroscopy. This study was designed to ascertain the ED90 of esketamine for inhibiting intraoperative movement responses in ...
Ruiqi Zhang, Chen Wang, Lin Wang, Wenyue Kang, Zhihua Wang   +4 more
doaj   +2 more sources

A New ‘Biased Coin Design’ for the Sequential Allocation of Two Treatments

Journal of the Royal Statistical Society Series C: Applied Statistics, 2004
SummaryEfron’s biased coin design is a well-known randomization technique that helps to neutralize selection bias in sequential clinical trials for comparing treatments, while keeping the experiment fairly balanced. Extensions of the biased coin design have been proposed by several researchers who have focused mainly on the large sample properties of ...
BALDI ANTOGNINI, ALESSANDRO, GIOVAGNOLI, ALESSANDRA   +1 more
openaire   +6 more sources

Determining the optimal ropivacaine concentration for spinal anaesthesia during day surgery for anorectal procedures: a dose-finding study [PDF]

Scientific Reports
Ropivacaine is a commonly utilized local anesthetic for spinal anesthesia (SA); however, its optimal concentration for elective anorectal surgery has not been thoroughly estimated.
Lu Chen, Xujun Dong, Jianhua Chen, Jintao Shen, Jian Liu, Shaojin Bu, Rongdan Tan, Xin-sen Zou   +7 more
doaj   +2 more sources

The 90% minimum effective concentration of ropivacaine for ultrasound‐guided interscalene brachial plexus block in children aged 1–10 years: A biased coin design up‐and‐down sequential allocation trial [PDF]

Pediatric Discovery
Ropivacaine is a commonly used local anesthetic for brachial plexus blocks in children, but the minimum effective dose of ropivacaine for interscalene brachial plexus blocks has not been reported.
Li Yang, Fei Yang, Yaqiong Tian, Ling Liu, Shangyingying Li, Tauseef Ahmad, Yuan Shi, Shengfen Tu   +7 more
doaj   +2 more sources

The Optimal Effective Concentration of Spinal Anesthesia for Interlaminar Endoscopic Lumbar Discectomy: An Approach Based on the Biased Coin Design [PDF]

Drug Design, Development and Therapy
Long Zhang,1,2,* Yu Zhang,1,2,* Ping Li,3 Bingwei Hu,4 Guanyi Liu,2,5 Miao Zhu,1,2 Liyong Yuan,1,2 Yaqing Xu1,2 1Department of Anesthesiology, Ningbo No.6 Hospital, Ningbo, Zhejiang, People’s Republic of China; 2Ningbo Clinical Research ...
Zhang L, Zhang Y, Li P, Hu B, Liu G, Zhu M, Yuan L, Xu Y   +7 more
doaj   +1 more source

Optimal Programmed Intermittent Epidural Bolus Interval for Video-Assisted Thoracic Surgery Lobectomy: A Biased-Coin Up-Down Study of Ropivacaine-Sufentanil [PDF]

Drug Design, Development and Therapy
Chengfei Feng,1,* Jijin Wen,2,* Guozhong Lai,3,* Xiaofan Lu,2 Guanli Luo,2 Yali Lu,2 Wei Li,2 Renchun Lai2 1Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University ...
Feng C, Wen J, Lai G, Lu X, Luo G, Lu Y, Li W, Lai R   +7 more
doaj   +2 more sources

Multi-objective optimal designs in comparative clinical trials with covariates: The reinforced doubly adaptive biased coin design

The Annals of Statistics, 2012
The present paper deals with the problem of allocating patients to two competing treatments in the presence of covariates or prognostic factors in order to achieve a good trade-off among ethical concerns, inferential precision and randomness in the ...
Antognini, Alessandro Baldi, Zagoraiou, Maroussa   +1 more
core   +5 more sources