Results 11 to 20 of about 9,554,450 (161)

Selecting a Biased-Coin Design

Statistical Science, 2014
Biased-coin designs are used in clinical trials to allocate treatments with some randomness while maintaining approximately equal allocation. More recent rules are compared with Efron's [Biometrika 58 (1971) 403-417] biased-coin rule and extended to allow balance over covariates.
Atkinson, Anthony C.
openaire   +4 more sources

Topical Airway Lidocaine Spray Reduces the 95% Effective Dose of Sufentanil for Blunting Hemodynamic Response to Tracheal Intubation in Elderly Patients: A Biased-Coin Up-and-Down Sequential Allocation Trial [PDF]

Drug Design, Development and Therapy
Xu Chen,1,* Jinjing Yang,2,* Kunyun Pan,1 Hao Wu,1 Sheng Wang,1 Wei Zhang,1 Chengwei Yang1 1Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology ...
Chen X, Yang J, Pan K, Wu H, Wang S, Zhang W, Yang C   +6 more
doaj   +2 more sources

Determination of the ED90 and ED99 of Liposomal versus Conventional Bupivacaine for Ultrasound-Guided Stellate Ganglion Block: A Biased-Coin Design Study [PDF]

Drug Design, Development and Therapy
Litong Yang,1,* Junxiang Liu,2,* Yutong Yang,3 Haodong Zhao,4 Zhidong Fan,3 Guangfen Yin,3 Qinghang Xuan3 1Department of Anesthesiology, Xiangyun County People’s Hospital, Dali, Yunnan, People’s Republic of China; 2Department of ...
Yang L, Liu J, Yang Y, Zhao H, Fan Z, Yin G, Xuan Q   +6 more
doaj   +2 more sources

Minimum Effective Volume of 0.25% Ropivacaine for Ultrasound-Guided Superior Trunk Block with Dexmedetomidine Sedation in Shoulder Arthroscopy: A Biased Coin Up-and-Down Trial [PDF]

Drug Design, Development and Therapy
Kai Wang,1,2,* Shuhan Zhang,1,* Zhaoyu Lv,1,* Wei Chen,1 Yonghua Li1 1Department of Anesthesiology, Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital), Shanghai, People’s Republic of China ...
Wang K, Zhang S, Lv Z, Chen W, Li Y
doaj   +2 more sources

The EC90 of remifentanil for inhibiting endotracheal intubation responses under anesthesia induction with ciprofol: study protocol for a dose-finding trial with the biased-coin design [PDF]

Trials
Background Tracheal intubation may cause significant hemodynamic responses. Many drugs have been shown to be effective in modifying these cardiovascular responses, including remifentanil, fentanyl, sufentanil, and alfentanil. However, the 90% effect-site
Jianing Guo, Fangsheng Xu, Luoyun Li, Zeru Zhang, Baichun Xing, Qin Fan, Zehua Wang, Chunyu Li   +7 more
doaj   +2 more sources

Sequential Treatment Allocation Using Biased Coin Designs

Journal of the Royal Statistical Society Series B: Methodological, 1984
SUMMARY Biased coin designs are used in clinical trials as a means of achieving approximate balance within a randomized design. In this paper, detailed results are obtained for a class of biased coin designs from the point of view of the degree of balance achieved, selection bias, accidental bias and inference following the randomized ...
exaly   +3 more sources

The 95% effective dose of dexmedetomidine to induce adequate sedation in patients with chronic insomnia disorder: a biased coin design up-and-down sequential allocation trial [PDF]

BMC Anesthesiology
Background Chronic insomnia disorder is a common sleep disorder. Previous studies have reported increased demand for anesthetics in patients with chronic insomnia disorder.
Mengya Li, Guifeng Li, Qifang Li, Qing Cai   +3 more
doaj   +2 more sources

The 90% minimum effective volume and concentration of lidocaine for ultrasound-guided stellate ganglion blocks in adults: a biased-coin design, up-and-down sequential allocation trial [PDF]

Korean Journal of Anesthesiology
Background As ultrasound imaging technology matured, stellate ganglion blocks (SGBs) have become increasingly precise and safe, and their use in clinical practice has become widespread. However, the 90% minimum effective volume (MEV90) and concentration (
Shujun Sun, Qinghua Yin, Jiwei Shen, Yang Lv, Long Li, Zhangyan Mao, Yun Lin, Xiangdong Chen, Dong Yang   +8 more
doaj   +2 more sources

Properties of Biased Coin Designs in Sequential Clinical Trials

Annals of Statistics, 1984
Several authors have proposed and studied designs in a clinical trial experiment of testing treatments. For example \textit{B. Efron} [cf. Biometrika 58, 403-417 (1971; Zbl 0226.62086)] proposed and studied a sequential biased design for two treatments \(R=2\).
exaly   +4 more sources

Determine of 90% Effective Dose of Oliceridine Combined with Etomidate for Inhibiting Laryngeal Mask Airway Insertion Responses in Patients of Different Ages: A Biased-Coin Sequential Allocation Dose-Finding Trial [PDF]

Drug Design, Development and Therapy
Fangsheng Xu,1,* Yuanyuan Cui,2,* Zhengle Wang,1 Rongguang Liu,1 Jian Tang,1 Yuan Xu,1 Luoyun Li,3 Chunyu Li,4 Meifang Wang,1 Jianfeng Pu1 1Department of Anesthesiology, Changshu No.
Xu F, Cui Y, Wang Z, Liu R, Tang J, Xu Y, Li L, Li C, Wang M, Pu J   +9 more
doaj   +2 more sources