Results 11 to 20 of about 5,006 (131)

Pharmacodynamics study of remimazolam besylate in anxious patients undergoing gastroscopy: a biased-coin design up-and-down sequential allocation trial [PDF]

BMC Anesthesiology
Background This study aimed to evaluate the impact of anxiety on the pharmacodynamics of remimazolam besylate in patients undergoing gastroscopy. Methods Patients undergoing gastroscopy were divided into two groups: an anxiety group (Self -rating Anxiety
Bao-Zhu Cha, Shuang-Yan Hu, Nian-Ping Chen, Jia-Fei Cao, Cheng Xu, Kai Qiu, Foquan Luo   +6 more
doaj   +2 more sources

Determination of the ED90 and ED99 of Liposomal versus Conventional Bupivacaine for Ultrasound-Guided Stellate Ganglion Block: A Biased-Coin Design Study [PDF]

Drug Design, Development and Therapy
Litong Yang,1,* Junxiang Liu,2,* Yutong Yang,3 Haodong Zhao,4 Zhidong Fan,3 Guangfen Yin,3 Qinghang Xuan3 1Department of Anesthesiology, Xiangyun County People’s Hospital, Dali, Yunnan, People’s Republic of China; 2Department of ...
Yang L, Liu J, Yang Y, Zhao H, Fan Z, Yin G, Xuan Q   +6 more
doaj   +2 more sources

A Sequential Probability Ratio Test Using a Biased Coin Design

Annals of Statistics, 1985
Consider a sequential probability ratio test comparing two treatments, where each subject receives only one of the treatments. Each subject's treatment assignment is determined by the flip of a biased coin, where the bias serves to balance the number of patients assigned to each treatment.
Nancy E Heckman
exaly   +3 more sources

The EC90 of remifentanil for inhibiting endotracheal intubation responses under anesthesia induction with ciprofol: study protocol for a dose-finding trial with the biased-coin design [PDF]

Trials
Background Tracheal intubation may cause significant hemodynamic responses. Many drugs have been shown to be effective in modifying these cardiovascular responses, including remifentanil, fentanyl, sufentanil, and alfentanil. However, the 90% effect-site
Jianing Guo, Fangsheng Xu, Luoyun Li, Zeru Zhang, Baichun Xing, Qin Fan, Zehua Wang, Chunyu Li   +7 more
doaj   +2 more sources

Sequential Treatment Allocation Using Biased Coin Designs

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1984
SUMMARY Biased coin designs are used in clinical trials as a means of achieving approximate balance within a randomized design. In this paper, detailed results are obtained for a class of biased coin designs from the point of view of the degree of balance achieved, selection bias, accidental bias and inference following the randomized ...
exaly   +3 more sources

The 95% effective dose of dexmedetomidine to induce adequate sedation in patients with chronic insomnia disorder: a biased coin design up-and-down sequential allocation trial [PDF]

BMC Anesthesiology
Background Chronic insomnia disorder is a common sleep disorder. Previous studies have reported increased demand for anesthetics in patients with chronic insomnia disorder.
Mengya Li, Guifeng Li, Qifang Li, Qing Cai   +3 more
doaj   +2 more sources

The 90% minimum effective volume and concentration of lidocaine for ultrasound-guided stellate ganglion blocks in adults: a biased-coin design, up-and-down sequential allocation trial [PDF]

Korean Journal of Anesthesiology
Background As ultrasound imaging technology matured, stellate ganglion blocks (SGBs) have become increasingly precise and safe, and their use in clinical practice has become widespread. However, the 90% minimum effective volume (MEV90) and concentration (
Shujun Sun, Qinghua Yin, Jiwei Shen, Yang Lv, Long Li, Zhangyan Mao, Yun Lin, Xiangdong Chen, Dong Yang   +8 more
doaj   +2 more sources

A Local Limit Theorem for a Biased Coin Design for Sequential Tests

Annals of Statistics, 1985
In a clinical comparison of responses to two treatments, patients are admitted sequentially and given one of the two treatments. The allocation is determined randomly, to decrease the possibility of personal bias in the selection of subjects for the test.
Nancy E Heckman
exaly   +3 more sources

Determine of 90% Effective Dose of Oliceridine Combined with Etomidate for Inhibiting Laryngeal Mask Airway Insertion Responses in Patients of Different Ages: A Biased-Coin Sequential Allocation Dose-Finding Trial [PDF]

Drug Design, Development and Therapy
Fangsheng Xu,1,* Yuanyuan Cui,2,* Zhengle Wang,1 Rongguang Liu,1 Jian Tang,1 Yuan Xu,1 Luoyun Li,3 Chunyu Li,4 Meifang Wang,1 Jianfeng Pu1 1Department of Anesthesiology, Changshu No.
Xu F, Cui Y, Wang Z, Liu R, Tang J, Xu Y, Li L, Li C, Wang M, Pu J   +9 more
doaj   +2 more sources

Properties of Biased Coin Designs in Sequential Clinical Trials

Annals of Statistics, 1984
Several authors have proposed and studied designs in a clinical trial experiment of testing treatments. For example \textit{B. Efron} [cf. Biometrika 58, 403-417 (1971; Zbl 0226.62086)] proposed and studied a sequential biased design for two treatments \(R=2\).
exaly   +4 more sources