Determination of ED90 and ED99 of Oliceridine combined with Propofol in inhibiting responses to gastroscope insertion: a biased coin up-and-down design [PDF]
BMC AnesthesiologyBackground Gastroscopy is a common medical procedure, but the insertion of the endoscope often causes significant discomfort and anxiety in patients, necessitating effective sedation strategies.
Zhiyong Tang +7 more
doaj +3 more sources
Selecting a biased-coin design
Statistical Science, 2014 Biased-coin designs are used in clinical trials to allocate treatments with some randomness while maintaining approximately equal allocation. More recent rules are compared with Efron's [Biometrika 58 (1971) 403-417] biased-coin rule and extended to ...
Atkinson, Anthony C.
core +4 more sources
Robust quantum state engineering through coherent localization in biased-coin quantum walks [PDF]
EPJ Quantum Technology, 2018 We address the performance of a coin-biased quantum walk as a generator for non-classical position states of the walker. We exploit a phenomenon of coherent localization in the position space - resulting from the choice of small values of the coin ...
Helena Majury +4 more
doaj +4 more sources
Statistica, 2007 Efron's (1971) Biased Coin Design is a well-known randomization technique of sequential clinical trials for comparing two treatments in the absence of prognostic factors that helps neutralize selection bias while keeping the experiment fairly balanced ...
Alessandro Baldi Antognini +2 more
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A new 'biased coin design' for the sequential allocation of two treatments
Journal of the Royal Statistical Society Series C: Applied Statistics, 2004 Efron's biased coin design is a well-known randomization technique that helps to neutralize selection bias in sequential clinical trials for comparing treatments, while keeping the experiment fairly balanced.
Alessandra Giovagnoli +1 more
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The EC90 of remifentanil for inhibiting endotracheal intubation responses under anesthesia induction with ciprofol: study protocol for a dose-finding trial with the biased-coin design [PDF]
TrialsBackground Tracheal intubation may cause significant hemodynamic responses. Many drugs have been shown to be effective in modifying these cardiovascular responses, including remifentanil, fentanyl, sufentanil, and alfentanil. However, the 90% effect-site
Jianing Guo +7 more
doaj +2 more sources
The 95% effective dose of dexmedetomidine to induce adequate sedation in patients with chronic insomnia disorder: a biased coin design up-and-down sequential allocation trial [PDF]
BMC AnesthesiologyBackground Chronic insomnia disorder is a common sleep disorder. Previous studies have reported increased demand for anesthetics in patients with chronic insomnia disorder.
Mengya Li +3 more
doaj +2 more sources
The 90% minimum effective volume and concentration of lidocaine for ultrasound-guided stellate ganglion blocks in adults: a biased-coin design, up-and-down sequential allocation trial [PDF]
Korean Journal of AnesthesiologyBackground As ultrasound imaging technology matured, stellate ganglion blocks (SGBs) have become increasingly precise and safe, and their use in clinical practice has become widespread. However, the 90% minimum effective volume (MEV90) and concentration (
Shujun Sun +8 more
doaj +2 more sources
Asymptotic properties of "Biased Coin'' Designs for treatment allocation
, 2004 Biased coin designs (BCD) are a special type of randomized sequential experiments. A common feature of several BCD’s is their Markov property, which allows a direct study of the design asymptotics.
GIOVAGNOLI, ALESSANDRA
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Determine of 90% Effective Dose of Oliceridine Combined with Etomidate for Inhibiting Laryngeal Mask Airway Insertion Responses in Patients of Different Ages: A Biased-Coin Sequential Allocation Dose-Finding Trial [PDF]
Drug Design, Development and TherapyFangsheng Xu,1,* Yuanyuan Cui,2,* Zhengle Wang,1 Rongguang Liu,1 Jian Tang,1 Yuan Xu,1 Luoyun Li,3 Chunyu Li,4 Meifang Wang,1 Jianfeng Pu1 1Department of Anesthesiology, Changshu No.
Xu F +9 more
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