Results 31 to 40 of about 69,041 (263)

Randomizing a clinical trial in neuro-degenerative disease

Contemporary Clinical Trials Communications, 2023
The paper studies randomization rules for a sequential two-treatment, two-site clinical trial in Parkinson’s disease. An important feature is that we have values of responses and five potential prognostic factors from a sample of 144 patients similar to ...
Anthony C. Atkinson, Belmiro P.M. Duarte, David J. Pedrosa, Marlena van Munster   +3 more
doaj   +1 more source

Conditioning Efron’s biased coin design to ensure final balance [PDF]

Electronic Journal of Statistics, 2021
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Nuovi indicatori di sbilanciamento e prevedibilità nei disegni sequenziali randomizzati: confronti fra 'biased coin designs' diversi

Statistica, 2007
Efron's (1971) Biased Coin Design is a well-known randomization technique of sequential clinical trials for comparing two treatments in the absence of prognostic factors that helps neutralize selection bias while keeping the experiment fairly balanced ...
Alessandro Baldi Antognini, Antonella Bodini, Alessandra Giovagnoli   +2 more
doaj   +1 more source

The minimum effective concentration (MEC90) of ropivacaine for ultrasound-guided caudal block in anorectal surgery. A dose finding study.

PLoS ONE, 2021
BackgroundCaudal epidural block (CEB) provides reliable anesthesia for adults undergoing anorectal surgery. Despite the widely utilization, the minimum effective concentration for 90% patients (MEC90) of ropivacaine for CEB remains unknown.ObjectiveTo ...
Xuehan Li, Jun Li, Pei Zhang, Huifei Deng, Mingan Yang, Hongbo He, Rurong Wang   +6 more
doaj   +1 more source

Determination of the 95% effective dose of remimazolam to achieve loss of consciousness during anesthesia induction in different age groups [PDF]

Korean Journal of Anesthesiology, 2022
Background Remimazolam is a new ultra short-acting benzodiazepine originally developed as an improved version of midazolam. Recent studies have demonstrated non-inferiority of remimazolam to propofol in general anesthesia.
Juyeon Oh, Sung Yong Park, Sook Young Lee, Ju Yeol Song, Ga Yun Lee, Ji Hyun Park, Han Bum Joe   +6 more
doaj   +1 more source

Optimization of programmed intermittent epidural bolus volume for different concentrations of ropivacaine in labor analgesia: a biased coin up-and-down sequential allocation trial

BMC Pregnancy and Childbirth, 2022
Background and objectives To date, programmed intermittent epidural bolus (PIEB) has been widely used in obstetric analgesia, while no optimal PIEB regimen has been proposed.
Xin Ran, Shuzhi Zhou, Kailan Cao, Peng He   +3 more
doaj   +1 more source

Exact properties of Efron's biased coin randomization procedure [PDF]

, 2010
Efron [Biometrika 58 (1971) 403--417] developed a restricted randomization procedure to promote balance between two treatment groups in a sequential clinical trial. He called this the biased coin design. He also introduced the concept of accidental bias,
Markaryan, Tigran, Rosenberger, William F.   +1 more
core   +1 more source

The estimation of minimum effective volume of 0.5% ropivacaine in ultrasound-guided interscalene brachial plexus nerve block: A clinical trial

Journal of Anaesthesiology Clinical Pharmacology, 2019
Background and Aims: Interscalene brachial plexus block (ISB) is the most commonly used mode of anesthesia for upper limb surgeries. Higher volume of local anesthetic used in ISB is associated with increased incidence of side effects, particularly ...
Kailash Mittal, Sarita Janweja, Prateek, Pushpender Sangwan, Deepa Agarwal, Himani Tak   +5 more
doaj   +1 more source

95% effective volume of ropivacaine for ultrasound‑guided supra‑inguinal fascia iliaca compartment block

BMC Anesthesiology, 2023
Background Hip arthroplasty is effective in treating hip diseases, such as osteoarthritis and hip fracture, but it often brings severe trauma and pain. In recent years, ultrasound-guided supra-inguinal fascia iliaca compartment block(S-FICB) has become a
Can Zhang, Wei Dai, Kaihua He
doaj   +1 more source

Study on MEV90 of 0.5% ropivacaine for US-guided caudal epidural block in anorectal surgery

Frontiers in Medicine, 2023
BackgroundChoosing the appropriate concentration and volume of anesthetics is critical for a successful nerve block. The current study aimed to determine the minimum effective volume (MEV) of 0.5% ropivacaine for US-guided CEB in 90% of patients (MEV90 ...
Pei Zhang, Hong Chang, Hong Chang, Hong Chang, Taoran Yang, Yalong Fu, Xuemei He, Jun Li, Mingan Yang, Rurong Wang, Rurong Wang, Xuehan Li   +11 more
doaj   +1 more source