The 90% minimum effective concentration of ropivacaine for ultrasound‐guided interscalene brachial plexus block in children aged 1–10 years: A biased coin design up‐and‐down sequential allocation trial [PDF]
Pediatric DiscoveryRopivacaine is a commonly used local anesthetic for brachial plexus blocks in children, but the minimum effective dose of ropivacaine for interscalene brachial plexus blocks has not been reported.
Li Yang +7 more
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Determination of the ED90 for Epidural Hydromorphone and Morphine for Postoperative Pain Using a Biased-Coin Up-and-Down Sequential Design After Elective Cesarean Delivery [PDF]
Drug Design, Development and TherapyXiaolin Tang,1,* Yu Liang,1,* Yuting Hu,1 Peng Li,1 Jiani Wang,1 Yujue Wang,2 Min Xie1 1Department of Anaesthesiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China ...
Tang X +6 more
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The 90% effective dose (ED90) of esketamine for inhibiting responses to intraoperative motor stimulation during ambulatory hysteroscopy: a biased-coin up-and-down sequential allocation trial [PDF]
BMC AnesthesiologyBackground Esketamine and remimazolam co-administration presents a viable opioid-free anesthetic alternative for outpatient hysteroscopy. This study was designed to ascertain the ED90 of esketamine for inhibiting intraoperative movement responses in ...
Ruiqi Zhang +4 more
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A doubly adaptive biased coin design.
, 1991 A doubly adaptive biased coin design is formulated for the allocation of patients to treatments A and B in a clinical trial. The design is doubly adaptive in the sense that it takes account of the proportion of patients assigned to each treatment and the
Eisele, Jeffrey Robert
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Determining the optimal ropivacaine concentration for spinal anaesthesia during day surgery for anorectal procedures: a dose-finding study [PDF]
Scientific ReportsRopivacaine is a commonly utilized local anesthetic for spinal anesthesia (SA); however, its optimal concentration for elective anorectal surgery has not been thoroughly estimated.
Lu Chen +7 more
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Optimal Programmed Intermittent Epidural Bolus Interval for Video-Assisted Thoracic Surgery Lobectomy: A Biased-Coin Up-Down Study of Ropivacaine-Sufentanil [PDF]
Drug Design, Development and TherapyChengfei Feng,1,* Jijin Wen,2,* Guozhong Lai,3,* Xiaofan Lu,2 Guanli Luo,2 Yali Lu,2 Wei Li,2 Renchun Lai2 1Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University ...
Feng C +7 more
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Frontiers in Pharmacology, 2023 Background and Purpose: The prevalence of elderly patients prompts anesthesiologists to determine the optimal dose of medication due to the altered pharmacokinetics and pharmacodynamics of this population.
Liangchao Qu +7 more
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ED95 of remimazolam in nasal administration for attenuating preoperative anxiety in children
Frontiers in Medicine, 2023 BackgroundPreoperative anxiety often prevails in children at higher levels than adults, which is a common impediment for surgeons and anesthesiologists. It is of great necessity to explore an appropriate medication to improve this situation. Remimazolam,
Xiang Long +6 more
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Randomizing a clinical trial in neuro-degenerative disease
Contemporary Clinical Trials Communications, 2023 The paper studies randomization rules for a sequential two-treatment, two-site clinical trial in Parkinson’s disease. An important feature is that we have values of responses and five potential prognostic factors from a sample of 144 patients similar to ...
Anthony C. Atkinson +3 more
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Bayesian and other biased-coin designs for sequential clinical trials
, 1999 A relationship is established between the Bayesian biased-coin design suggested by Ball et al. (1993) [F. G. Ball, A. F. M. Smith, I. Verdinelli: Biased coin designs with a Bayesian bias, J. Statist. Plann.
Atkinson, Anthony
core +6 more sources