Results 21 to 30 of about 20,682 (267)

Adaptive biased-coin designs for clinical trials with several treatments

Discussiones Mathematicae Probability and Statistics, 2004
Adaptive designs are used in phase III clinical trials for skewing the allocation pattern towards the better treatments. We use optimum design theory to provide a skewed biased-coin procedure for sequential designs with continuous responses.
Atkinson, Anthony
core   +3 more sources

The 90% minimum effective concentration of ropivacaine for ultrasound‐guided interscalene brachial plexus block in children aged 1–10 years: A biased coin design up‐and‐down sequential allocation trial [PDF]

Pediatric Discovery
Ropivacaine is a commonly used local anesthetic for brachial plexus blocks in children, but the minimum effective dose of ropivacaine for interscalene brachial plexus blocks has not been reported.
Li Yang, Fei Yang, Yaqiong Tian, Ling Liu, Shangyingying Li, Tauseef Ahmad, Yuan Shi, Shengfen Tu   +7 more
doaj   +2 more sources

Balance and randomness in sequential clinical trials: the dominant biased coin design

Pharmaceutical Statistics, 2014
Efron’s biased coin design (BCD) is a well-known randomization technique that helps neutralize selection bias, while keeping the experiment fairly balanced for every sample size.
ZAGORAIOU, MAROUSSA, BALDI ANTOGNINI, ALESSANDRO, Alessandro Baldi Antognini, Maroussa Zagoraiou   +3 more
core   +3 more sources

Determination of the ED90 for Epidural Hydromorphone and Morphine for Postoperative Pain Using a Biased-Coin Up-and-Down Sequential Design After Elective Cesarean Delivery [PDF]

Drug Design, Development and Therapy
Xiaolin Tang,1,* Yu Liang,1,* Yuting Hu,1 Peng Li,1 Jiani Wang,1 Yujue Wang,2 Min Xie1 1Department of Anaesthesiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China ...
Tang X, Liang Y, Hu Y, Li P, Wang J, Wang Y, Xie M   +6 more
doaj   +2 more sources

The 90% effective dose (ED90) of esketamine for inhibiting responses to intraoperative motor stimulation during ambulatory hysteroscopy: a biased-coin up-and-down sequential allocation trial [PDF]

BMC Anesthesiology
Background Esketamine and remimazolam co-administration presents a viable opioid-free anesthetic alternative for outpatient hysteroscopy. This study was designed to ascertain the ED90 of esketamine for inhibiting intraoperative movement responses in ...
Ruiqi Zhang, Chen Wang, Lin Wang, Wenyue Kang, Zhihua Wang   +4 more
doaj   +2 more sources

Determining the optimal ropivacaine concentration for spinal anaesthesia during day surgery for anorectal procedures: a dose-finding study [PDF]

Scientific Reports
Ropivacaine is a commonly utilized local anesthetic for spinal anesthesia (SA); however, its optimal concentration for elective anorectal surgery has not been thoroughly estimated.
Lu Chen, Xujun Dong, Jianhua Chen, Jintao Shen, Jian Liu, Shaojin Bu, Rongdan Tan, Xin-sen Zou   +7 more
doaj   +2 more sources

Multi-objective optimal designs in comparative clinical trials with covariates: the reinforced doubly-adaptive biased coin design

The Annals of Statistics, 2012
The present paper deals with the problem of allocating patients to two competing treatments in the presence of covariates or prognostic factors in order to achieve a good trade-off among ethical concerns, inferential precision and randomness in the ...
ZAGORAIOU, MAROUSSA, BALDI ANTOGNINI, ALESSANDRO, Alessandro Baldi Antognini, Maroussa Zagoraiou   +3 more
core   +6 more sources

Optimal Programmed Intermittent Epidural Bolus Interval for Video-Assisted Thoracic Surgery Lobectomy: A Biased-Coin Up-Down Study of Ropivacaine-Sufentanil [PDF]

Drug Design, Development and Therapy
Chengfei Feng,1,* Jijin Wen,2,* Guozhong Lai,3,* Xiaofan Lu,2 Guanli Luo,2 Yali Lu,2 Wei Li,2 Renchun Lai2 1Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University ...
Feng C, Wen J, Lai G, Lu X, Luo G, Lu Y, Li W, Lai R   +7 more
doaj   +2 more sources

The 90% effective dose of spinal ropivacaine for external cephalic version: A sequential dose-finding study [PDF]

Journal of International Medical Research
Objective Although spinal anesthesia can improve the success of external cephalic version, the optimal analgesic dose of ropivacaine remains undefined, and higher doses may increase potential risks. This study aimed to determine the 90% effective dose of
Qiao Shi, Jing Zheng, Tao Xu, Jing Chai, Rui Ma   +4 more
doaj   +2 more sources

Maximum effective volume of 0.25% ropivacaine for preventing hemidiaphragmatic paralysis in 90% of patients undergoing shoulder arthroscopy: a biased coin up-and-down sequential allocation trial for ultrasound-guided superior trunk block [PDF]

BMC Anesthesiology
Background Compared to interscalene block (ISB), the superior trunk block (STB) lowers the incidence of hemidiaphragmatic paralysis (HDP) without compromising analgesic efficacy, making it a valuable alternative.
Kai Wang, Hongwei Zhu, Yangyang Zhou, Shukai Gui, Yonghua Li   +4 more
doaj   +2 more sources