Results 41 to 50 of about 5,006 (131)
Study on MEV90 of 0.5% ropivacaine for US-guided caudal epidural block in anorectal surgery
Frontiers in Medicine, 2023 BackgroundChoosing the appropriate concentration and volume of anesthetics is critical for a successful nerve block. The current study aimed to determine the minimum effective volume (MEV) of 0.5% ropivacaine for US-guided CEB in 90% of patients (MEV90 ...
Pei Zhang +11 more
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Determination of the 95% effective dose of remimazolam to achieve loss of consciousness during anesthesia induction in different age groups [PDF]
Korean Journal of Anesthesiology, 2022 Background Remimazolam is a new ultra short-acting benzodiazepine originally developed as an improved version of midazolam. Recent studies have demonstrated non-inferiority of remimazolam to propofol in general anesthesia.
Juyeon Oh +6 more
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The distribution of loss in two-treatment biased-coin designs [PDF]
Biostatistics, 2003 The paper compares randomized rules of the biased-coin type for the sequential allocation of treatments in a clinical trial. An important characteristic is the loss, which measures the increase in the variance of parameter estimates due to the imbalance caused by randomization. Simulations are used to find the small-sample distribution of loss.
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Seamless Clinical Trials with Doubly Adaptive Biased Coin Designs
The New England Journal of Statistics in Data Science, 2023 In addition to scientific questions, clinical trialists often explore or require other design features, such as increasing the power while controlling the type I error rate, minimizing unnecessary exposure to inferior treatments, and comparing multiple treatments in one clinical trial.
Hongjian Zhu +3 more
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Selecting a Biased-Coin Design
Statistical Science, 2014 Biased-coin designs are used in clinical trials to allocate treatments with some randomness while maintaining approximately equal allocation. More recent rules are compared with Efron's [Biometrika 58 (1971) 403-417] biased-coin rule and extended to allow balance over covariates.
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Journal of Obstetric Anaesthesia and Critical Care, 2017 Background: Oxytocin, a commonly used drug to prevent uterine atony after caesarean section, should be administered as dilute rapid infusion rather than as a bolus. This study was conducted to calculate ED90 of oxytocin infusion during caesarean delivery
Shashikiran +3 more
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Central Limit Theorems for Doubly Adaptive Biased Coin Designs
The Annals of Statistics, 1995 Subjects are assumed to arrive sequentially at an experimental site and are immediately assigned to one of two treatments \(A\) or \(B\). Responses from the subjects for the treatments are assumed to be independent random variables from exponential families. Let \(\rho\) denote the desired allocation proportion under Eiseles biased coin design [\textit{
Eisele, Jeffrey R. +1 more
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Asymptotic properties of doubly adaptive biased coin designs for multitreatment clinical trials [PDF]
The Annals of Statistics, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hu, Feifang, Zhang, Li-Xin
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BMC AnesthesiologyObjective To determine the effective dose of ciprofol in combination with remifentanil for successful laryngeal mask airway (LMA) placement without the use of muscle relaxants.
Xiaojian Lu +4 more
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Doubly adaptive biased coin designs for balancing competing objectives in time-to-event trials [PDF]
Statistics and Its Interface, 2012 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Sverdlov, Oleksandr +2 more
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