Results 41 to 50 of about 9,554,450 (161)
Central Limit Theorems for Doubly Adaptive Biased Coin Designs
The Annals of Statistics, 1995 Subjects are assumed to arrive sequentially at an experimental site and are immediately assigned to one of two treatments \(A\) or \(B\). Responses from the subjects for the treatments are assumed to be independent random variables from exponential families. Let \(\rho\) denote the desired allocation proportion under Eiseles biased coin design [\textit{
Eisele, Jeffrey R. +1 more
openaire +2 more sources
Journal of Obstetric Anaesthesia and Critical Care, 2017 Background: Oxytocin, a commonly used drug to prevent uterine atony after caesarean section, should be administered as dilute rapid infusion rather than as a bolus. This study was conducted to calculate ED90 of oxytocin infusion during caesarean delivery
Shashikiran +3 more
doaj +1 more source
The Adaptive Biased Coin Design for Sequential Experiments
The Annals of Statistics, 1978 In comparing two treatments, eligible subjects come to the experiment sequentially and must be treated at once. To reduce experimental bias and to increase the precision of inference about treatment effects, the adaptive biased coin design, which offers a compromise between perfect balance and complete randomization, is proposed and analyzed.
openaire +3 more sources
Seamless Clinical Trials with Doubly Adaptive Biased Coin Designs
The New England Journal of Statistics in Data Science, 2023 In addition to scientific questions, clinical trialists often explore or require other design features, such as increasing the power while controlling the type I error rate, minimizing unnecessary exposure to inferior treatments, and comparing multiple treatments in one clinical trial.
Hongjian Zhu +3 more
openaire +1 more source
Inference following biased coin designs in clinical trials. [PDF]
, 2013 PhDRandomization schemes for two-treatment clinical trials are studied. Theoretical expressions for the power are derived under both complete randomization and Efron’s biased coin design for normal and binary responses.
Yeung, Wai Yin
core +4 more sources
Asymptotic properties of doubly adaptive biased coin designs for multitreatment clinical trials [PDF]
The Annals of Statistics, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hu, Feifang, Zhang, Li-Xin
openaire +2 more sources
Frontiers in MedicineObjectiveTo determine the 90% effective dose (ED90) of remimazolam in combination with sufentanil for sedation in patients undergoing gastroscopy.MethodsFifty-six patients aged 18–65 years with ASA physical status I–II and a BMI of 18–30 kg/m2 who were ...
Yan Chen +3 more
doaj +1 more source
Simulations of a New Response-adaptive Biased Coin Design [PDF]
, 2015 Modern medical experiments accrue and treat patients--hence obtain treatment response data--throughout a trial. Designs which prospectively plan to modify patient allocation by leveraging accumulating data are response-adaptive randomization (RAR ...
Stein, Aleksandra, Stein, Aleksandra M
core
A Local Limit Theorem for a Biased Coin Design for Sequential Tests
The Annals of Statistics, 1985 In a clinical comparison of responses to two treatments, patients are admitted sequentially and given one of the two treatments. The allocation is determined randomly, to decrease the possibility of personal bias in the selection of subjects for the test.
openaire +2 more sources
Doubly adaptive biased coin designs for balancing competing objectives in time-to-event trials [PDF]
Statistics and Its Interface, 2012 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Sverdlov, Oleksandr +2 more
openaire +2 more sources