Results 51 to 60 of about 5,006 (131)

Generalized Efron's biased coin design and its theoretical properties

Journal of Applied Probability, 2016
AbstractIn clinical trials with two treatment arms, Efron's biased coin design, Efron (1971), sequentially assigns a patient to the underrepresented arm with probabilityp> ½. Under this design the proportion of patients in any arm converges to ½, and the convergence rate isn-1, as opposed ton-½under some other popular designs.
openaire   +3 more sources

The minimum effective concentration (MEC90) of bupivacaine for an ultrasound-guided suprainguinal fascia iliaca compartment block for analgesia in knee surgery: a dose-finding study [PDF]

Korean Journal of Anesthesiology
Background In recent years, the suprainguinal fascia iliaca compartment block (SFICB) has become more common in clinical practice. This assessor-blinded dose-finding study aimed to determine the minimum effective concentration (MEC90, MEC95) of ...
Caner Genc, Serkan Tulgar, Murat Unal, Ahmet Serhat Genc, Lokman Kehribar, Basar Erdivanli, Kris Vermeylen, Ersin Koksal   +7 more
doaj   +1 more source

Biased coin designs: some properties and applications

, 1995
A brief review of biased coin designs is presented. Some asymptotic properties of the adaptive biased coin designs of Wei (1978) and Eisele (1994) are given. Applications of biased coin designs to estimation and testing problems are also given.
openaire   +2 more sources

Minimum effective concentration of ropivacaine for ultrasound-guided pericapsular nerve group block to relieve spinal anesthesia positioning pain in elderly patients with femoral intertrochanteric fracture: a double-blind biased-coin dose-finding study

Frontiers in Medicine
BackgroundThe optimal ropivacaine concentration for ultrasound-guided pericapsular nerve group (PENG) block to relieve spinal anesthesia positioning pain in elderly patients with femoral intertrochanteric fracture remains unclear.
Wenwen Zhai, Feng Yue, Yujie Wang, Yujie Wang, Mingfeng Mao, Fenglin Guo, Fang Guo, Bo Jiang, Min Li, Min Li, Xiangyang Guo, Xiangyang Guo   +11 more
doaj   +1 more source

The EC90 of remifentanil for blunting cardiovascular responses to head fixation for neurosurgery under total intravenous anesthesia with propofol and remifentanil based on bispectral index monitoring: estimation with the biased coin up-and-down sequential method

BMC Anesthesiology, 2017
Background Head fixation can induce hemodynamic instability. Remifentanil is commonly used with propofol for total intravenous anesthesia (TIVA) during neurosurgery.
Jung-Man Lee, Jae-Hyon Bahk, Young-Jin Lim, Jiwon Lee, Leerang Lim   +4 more
doaj   +1 more source

Multi-objective optimal designs in comparative clinical trials with covariates: The reinforced doubly adaptive biased coin design

The Annals of Statistics, 2012
The present paper deals with the problem of allocating patients to two competing treatments in the presence of covariates or prognostic factors in order to achieve a good trade-off among ethical concerns, inferential precision and randomness in the treatment allocations.
BALDI ANTOGNINI, ALESSANDRO, ZAGORAIOU, MAROUSSA   +1 more
openaire   +5 more sources

Sugammadex ED90 dose to reverse the rocuronium neuromuscular blockade in obese patients

Revista do Colégio Brasileiro de Cirurgiões
Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery.
MAURO PRADO DA SILVA, CHRISTIANO MATSUI, DANIEL DONGIOU KIM, JOAQUIM EDSON VIEIRA, CARLOS ALBERTO MALHEIROS, LIGIA ANDRADE SILVA TELLES MATHIAS   +5 more
doaj   +1 more source

Minimum effective concentration 90 (EC90) of ropivacaine for Femoral nerve block: A biased-coin up-and-down sequential method study

Indian Journal of Anaesthesia
Background and Aims: The femoral nerve (FN) is commonly blocked using ropivacaine to provide postoperative analgesia after knee surgery. However, the minimal required concentration has not yet been defined.
Ahmed M. Taha, Manjusha Mohanan, Sebastian Orduna, Ahmed F. Alalwi, Mohamed I. Badr, Ahmed M. Abd-Elmaksoud   +5 more
doaj   +1 more source

Age-Stratified ED95 of Remimazolam Tosilate for Moderate Sedation in Pediatric Patients: A Biased Coin Design Study

Drug Design, Development and Therapy
Bingqing Zhu,* Wenjun Meng,* Kunyun Pan,* Li Peng, Xu Chen, Sheng Wang, Chengwei Yang Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and ...
Zhu B, Meng W, Pan K, Peng L, Chen X, Wang S, Yang C   +6 more
doaj  

The MEC90 of Ropivacaine for Ultrasound-Guided Pectoral Nerve Block Type II for Modified Radical Mastectomy: A Biased-Coin Up-and-Down Sequential Trial

Drug Design, Development and Therapy
Yu Du,1 Wenbo Liu,1 Yangyang Wu,2 Lin Ma,1 Yi Tang,1 Ji Wang31Department of Anesthesiology, The Affiliated Nanchong Central Hospital of North Sichuan Medical College, Beijing Anzhen Nanchong Hospital of Capital Medical University, Nanchong, Sichuan ...
Du Y, Liu W, Wu Y, Ma L, Tang Y, Wang J
doaj