Results 51 to 60 of about 2,779,234 (237)

Projections Onto Order Simplexes and Isotonic Regression

, 2006
Isotonic regression is the problem of fitting data to order constraints. This problem can be solved numerically in an efficient way by successive projections onto order simplex constraints.
Kearsley, Anthony J.
core   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Efficacy of Employment of Isotonic Sterofundin after Experimental Hemorrhagic Shock

Общая реаниматология, 2013
Objective: to perform an experimental study of the effect of isotonic sterofundin on the morphology of the myocardium, kidney, lung, pancreas, liver, and brain in the late period after hemorrhagic shock. Material and methods.
A. Yu Yakovlev, V. V. Kichin, V. O Nikolsky, G. V. Kalentyev, D. V., Ryabikov, M. A. Ryabikova, D. M Protasov, T. A. Galanina, A. Yu. Smerkalov, O. S. Evdokimova   +9 more
doaj   +1 more source

Physiological manipulation and formulation of the biocontrol yeast Pichia anomala for control of Penicillium verrucosum and ochratoxin A contamination of moist grain. [PDF]

, 2008
The major hurdle in the production of commercial biocontrol agents (BCAs) has been the lack of production of appropriate formulations. Of particular importance is the conservation of viability and ecological competence after application.
Mokiou, Stella, Magan, Naresh
core   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Osmotic behaviour of human mesenchymal stem cells: Implications for cryopreservation.

PLoS ONE, 2017
Aimed at providing a contribution to the optimization of cryopreservation processes, the present work focuses on the osmotic behavior of human mesenchymal stem cells (hMSCs).
Elisa Casula, Gino P Asuni, Valeria Sogos, Sarah Fadda, Francesco Delogu, Alberto Cincotti   +5 more
doaj   +1 more source

An Unbiased Geometry‐Resolved Membrane Platform for Proteome‐Scale Discovery of Membrane Curvature Sensors

Advanced Science, EarlyView.
A novel geometry‐resolved membrane platform provides a seamlessly integrated pipeline for studying curvature‐sensing proteins. By linking shotgun proteomics with quantitative imaging, this approach enables both the unbiased discovery and rigorous validation of novel sensors across the entire curvature range—positive, negative, and zero.
Takumi Komikawa, Rikuto Kawakami, Kunanon Chattrairat, Tatsuya Niwa, Taiga Ajiri, Takao Yasui, Masayoshi Tanaka   +6 more
wiley   +1 more source

Comparative Efficacy of preservative vs. isotonic fluids in liver transplantation: A scoping review

Journal of the Pakistan Medical Association
Objective: To evaluate the comparative efficacy of preservative solutions versus isotonic fluids in living donor liver transplantation. Method: The scoping review was conducted from June 1, 2024, to January 1, 2025, and comprised comprehensive ...
Muhammad Salman, Saira Imtiaz, Talha Bukhari, Irfan Ahmed   +3 more
doaj   +1 more source

Effect of isotonic and hypotonic fluid therapy on serum sodium: A Randomized Controlled Trial

Acta Medica Iranica, 2020
There is little consensus about type of the maintenance fluid therapy and it’s effect on serum sodium in adults. Thus, this study was conducted to assess the effect of maintenance fluid therapy on serum sodium of hospitalized patients in intensive care ...
Moslem Sedaghattalab, Soheila Khajezadeh, Akvan Paymard, Parisa Mansuri, Rozina Abasi Larki, Leila Manzouri   +5 more
doaj   +1 more source

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source