Results 31 to 40 of about 120,968 (266)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Theoretical Study of H/D Isotope Effects on Nuclear Magnetic Shieldings Using an ab initio Multi-Component Molecular Orbital Method

Molecules, 2013
We have theoretically analyzed the nuclear quantum effect on the nuclear magnetic shieldings for the intramolecular hydrogen-bonded systems of σ-hydroxy acyl aromatic species using the gauge-including atomic orbital technique combined with our multi ...
Masanori Tachikawa, Takayoshi Ishimoto, Taro Udagawa   +2 more
doaj   +1 more source

Isotope Effect and Isotope Separation

Nippon kagaku zassi, 1968
同位体物質の換算分配関数比の値を, 量子統計論に基づき, 分子振動スペクトルからの知見を用いて算定した。これらの結果は同位体分離の研究に一つの基礎を与える。同位体物質が二相に分配するとき, 化学反応が同位体の分離効果にどのような影響をおよぼすかについて理論的な考察(二相分配理論) を行なった。導出された基礎式から, どのような系がもっとも分離効果が大きいかを知ることができる。二三の簡単な系について, この理論を展開した。さらにイオン交換樹脂を用いて, 実際にリチウム, 窒素, 銅, ウラン同位体の分離実験を行ない, 相分配理論によって解析を試みた。
openaire   +2 more sources

Isotope effect on the Casimir force

Science China Physics, Mechanics & Astronomy, 2023
Isotopic dependence of the Casimir force is key to probing new physics and pushing novel technologies at the micro and nanoscale, but is largely unexplored. In 2002, an isotope effect of 10^(-4) was estimated for metals -- orders of magnitude beyond the experimental resolution.
Xie, Lanyi, Yang, Fuwei, Song, Bai
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

A summary of the 10th Asia-Pacific Transport Working Group (APTWG) meeting

Nuclear Fusion
This conference report summarizes contributed papers and discussions presented at the 10th Asia-Pacific Transport Working Group (APTWG) held at Hanyang University, Seoul, South Korea from 13 to 16 June 2023.
W. Lee, Q. Zou, N. Wu, G.J. Choi, J.Q. Xu, K.N. Geng, F. Kin   +6 more
doaj   +1 more source

Development of the Direct Deuteration Method for Amino Acids and Characterization of Deuterated Tryptophan

Bioengineering
Proteins and peptides are vital biomolecules, and deuterated amino acids are increasingly applied in areas such as drug discovery, metabolic tracing, and neutron scattering studies.
Chie Shibazaki, Haruki Sugiyama, Misaki Ueda, Takayuki Oku, Motoyasu Adachi, Zoë Fisher, Kazuhiro Akutsu-Suyama   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Isotope-Selective Hydrogen-Bond Network Modulations at Plasmonic Gold Nanoparticle Interfaces Probed by Near-Infrared Spectroscopy

Electrochemistry
Localized surface plasmon resonance (LSPR) in metal nanostructures generates intense, spatially confined electric fields. At the present stage, direct experimental evidence for LSPR-induced perturbations at solid–liquid interfaces remains limited.
Hiro MINAMIMOTO, Naoki KAWASHIMA, Hiroki ONISHI, Minoru MIZUHATA   +3 more
doaj   +1 more source