Results 91 to 100 of about 188,123 (308)
Advanced Science, EarlyView.ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li +8 more
wiley +1 more source
AnimalsHaemonchosis caused by the parasitic worm Haemonchus contortus is a major threat to cattle and other ruminants and imposes significant economic losses in the livestock industry.
Yaqian Jin +3 more
doaj +1 more source
The linguistic status of Isotype
, 2011 It is ironic that Otto Neurath, one of those responsible for the ‘linguistic turn’ in philosophy of the twentieth century, should have been concerned during the last twenty years of his life with developing a ‘pictorial language’.
Burke, Christopher
core
Isolation and characterisation of a beta tubulin isotype 2 gene from two species of cyathostomin
, 2005 This study describes the isolation and characterisation of beta tubulin isotype 2 cDNA sequences from two common species of cyathostomin, Cylicocyclus nassatus and Cyathostomian catinatum.
Kaplan, R. M. +3 more
core +1 more source
Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening
Advanced Science, EarlyView.Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun +6 more
wiley +1 more source
Isotype: design and contexts 1925–1971
, 2013 The work in graphic communication carried out by Otto Neurath and his associates – now commonly known simply as Isotype – has been the subject of much interest in recent years.
core
, 2017 Microtubules (MTs) are polymers composed of α- and β-tubulin heterodimers, which are generally encoded by multiple gene loci. Despite implications of distinct properties of isotypes, how they contribute to diverse MT dynamics in vivo remains unclear ...
Eisuke Sumiyoshi +4 more
core +1 more source
Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils
Advanced Science, EarlyView.We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr +19 more
wiley +1 more source
Triple, double & single positivity per antibody isotype in APS.
, 2016 Triple, double & single positivity per antibody isotype in APS.
Thomas McDonnell (2814082) +12 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin +16 more
wiley +1 more source