Results 71 to 80 of about 188,123 (308)

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Isotypic Decompositions of Lattice Determinants

Journal of Combinatorial Theory, Series A, 1999
\textit{A. M. Garsia} and \textit{M. Haiman} [Proc. Natl. Acad. Sci. USA 90, No. 8, 3607-3610 (1993; Zbl 0831.05062)] have conjectured that the \(q,t\)-Macdonald polynomials have a representation theoretic interpretation in terms of the \(S_n\)-module spanned by the partial derivatives of \(\Delta_{\mu}({\mathbf x}; {\mathbf y}) = \det[x_i^{h_j} y_i ...
openaire   +2 more sources

Why Maintain Light Chain Isotypes? The Influence of Heavy Chain Isotype and Complementary Determining Region Lengths upon Light Chain Isotype in Xenopus laevis [PDF]

, 2016
Different immunoglobulin (Ig) heavy chain (H) isotypes have distinct functions, but so far it is unclear if Ig light (L) chains follow the same pattern.
Jacobs, Natalie Jo
core  

Immunoglobulin Isotype Deficiency Together with Allergic Diseases [PDF]

, 2016
Objective: Frequent infection is the most common reason for presentation to outpatient clinics during infancy and in the pre-school period. The aim of this study was to evaluate the incidence of allergic disorders in patients who apply to our allergy ...
Haskologlu, Zehra Sule, Koste Bal, Sevgi, Ikinciogullari, Kamile Aydan, Altun, Demet, İkincioğulları, Kamile Aydan, Akpınar, Melis, Akpinar, Melis, Kavgaci, Akif, Dogu, Esin Figen, Kavgacı, Akif, ALTUN BİNGÖL, Demet   +10 more
core   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Investigating a chimeric anti-mouse PDGFRα antibody as a radiosensitizer in primary mouse sarcomasResearch in context

EBioMedicine, 2019
Background: Olaratumab (LY3012207/IMC-3G3/Lartruvo™) is a fully human monoclonal antibody specific for platelet-derived growth factor receptor alpha (PDGFRα).
Erin J. Song, Kathleen A. Ashcraft, Caitlin D. Lowery, Yvonne M. Mowery, Lixia Luo, Yan Ma, Lorraine Da Silva Campos, Diana M. Cardona, Louis Stancato, David G. Kirsch   +9 more
doaj   +1 more source

List of isotype antibodies for immunostaining.

, 2015
Only the final dilutions used are listed.List of isotype antibodies for immunostaining.
Antonio Zarzuelo (748015), F. Javier Carreras (748010), David Porcel (748012), Olga Martínez-Agustin (748014), Carlos J. Aranda (748011), Francisco Rodriguez-Hurtado (748013)   +5 more
core   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Preliminary evidence for the occurrence of β-tubulin isotype 3 polymorphisms in Fasciola hepatica isolates in cattle and sheep in Turkey

Helminthologia, 2019
Fasciolosis caused by Fasciola hepatica is a common parasitic disease of livestock especially sheep and cattle. In this study molecular characterization of β-tubulin isotype 3 gene in Fasciola hepatica isolates from cattle and sheep in Turkey was carried
Canakoglu S. Sadet, Simsek S., Balkaya I., Kilinc S. Gunyakti   +3 more
doaj   +1 more source