Results 81 to 90 of about 188,123 (308)

Isotype Switching Increases Efficacy of Antibody Protection against Staphylococcal Enterotoxin B-Induced Lethal Shock and Staphylococcus aureus Sepsis in Mice

mBio, 2014
Staphylococcal enterotoxin B (SEB) is a potent toxin that is produced by Staphylococcus aureus strains and is classified as a category B select agent.
Avanish K. Varshney, Xiaobo Wang, Jorge L. Aguilar, Matthew D. Scharff, Bettina C. Fries   +4 more
doaj   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Isotype controls for MMP 9 immunohistochemistry.

, 2018
To control for specificity of the staining isotype IGG controls were performed (right panel) on the respective postoperative days (POD). scale bar 150 μm. (TIF)
Vanessa Twardy (4993850), Christiane Geyer (4993853), Christiane Geyer, Philipp Lenz (633585), Annika Mohr, Philipp-Alexander Neumann (4993859), Annika Mohr (3129045), Philipp-Alexander Neumann, Emile Rijcken, Felix Becker (783408), Andreas Faust (2185699), Katrin Schwegmann (430826), Felix Becker, Andreas Faust, Philipp Lenz, Vanessa Twardy, Emile Rijcken (4993856), Katrin Schwegmann   +17 more
core   +1 more source

Trajectories of class–switching‐related egg and cow's milk allergen‐specific immunoglobulin isotype formation and its modification by eczema with low‐ and high‐affinity immunoglobulin E during early infancy

Immunity, Inflammation and Disease, 2019
Introduction Allergen‐specific immunoglobulin isotype formation associated with immunoglobulin class‐switching during the lactation period is the immunological background for food allergy in infants.
Makoto Irahara, Wakako Shinahara, Mayumi Sugimoto, Yukiko Ogawa, Keiji Shitsukawa, Kenji Kubota, Limin Yang, Yukihiro Ohya, Hirohisa Saito, Shoji Kagami, Kokichi Arisawa, Hiroshi Kido   +11 more
doaj   +1 more source

Benzimidazole resistance survey for Haemonchus, Teladorsagia and Trichostrongylus in three European countries using pyrosequencing including the development of new assays for Trichostrongylus

International Journal for Parasitology: Drugs and Drug Resistance, 2016
Resistance to benzimidazoles (BZs) in trichostrongyloid nematodes is a worldwide problem for livestock production, particularly regarding small ruminants. Sensitive and reliable methods are required to assess anthelmintic resistance status.
Sabrina Ramünke, Lynsey Melville, Laura Rinaldi, Hubertus Hertzberg, Theo de Waal, Georg von Samson-Himmelstjerna, Giuseppe Cringoli, Fabien Mavrot, Philip Skuce, Jürgen Krücken, Janina Demeler   +10 more
doaj   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

A Study of a-Sic/C-Si(n) Isotype Heterojunctions

Active and Passive Electronic Components, 1993
In the present work a study of the electrical properties of heterojunctions between rf sputtered amorphous silicon carbide (a-SiC) thin films and n-type crystalline silicon (c-Si) substrates is reported. The current-voltage (I-V) and capacitance-voltage (
N. Georgoulas, L. Magafas, A. Thanailakis   +2 more
doaj   +1 more source

Isotype determination of monoclonal antibodies by immunodiffusion

, 1990
Immunodiffusion is an important qualitative method for the detection of antigens and antibodies. The technique may be used to determine the immunoglobulin heavy and light chain class and subclass of hybridoma antibodies.
Gustafsson, B
core   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

An essential role for α4A-tubulin in platelet biogenesis

Life Science Alliance, 2019
Alpha4A-tubulin is the predominant α-tubulin isotype in platelets. Mutations in α4A-tubulin cause abnormal platelet biogenesis and marginal band formation in mice and in a patient, establishing an essential role of this tubulin isotype.
Catherine Strassel, Maria M Magiera, Arnaud Dupuis, Morgane Batzenschlager, Agnès Hovasse, Irina Pleines, Paul Guéguen, Anita Eckly, Sylvie Moog, Léa Mallo, Quentin Kimmerlin, Stéphane Chappaz, Jean-Marc Strub, Natarajan Kathiresan, Henri de la Salle, Alain Van Dorsselaer, Claude Ferec, Jean-Yves Py, Christian Gachet, Christine Schaeffer-Reiss, Benjamin T Kile, Carsten Janke, François Lanza   +22 more
doaj   +1 more source