Results 161 to 170 of about 49,108 (308)

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Expression et polymorphisme des isotypes C-LAMBDA humains

, 2000
Le locus des chaînes légères lambda chez l'humain contient 7 segments de gènes constants. De ces 7 segments de gènes, 4 sont fonctionnels et peuvent être exprimés avec les 39 segments de gènes variables fonctionnels. Lors de cette étude, une méthode
Naud, Jean-François
core  

Tubulin E-Hook Hexamers Reveal Sequence-Dependent Compaction and Transient Secondary Structure Signatures. [PDF]

Molecules
Bromley AC, Kruse NA, Brower CR, Beam MK, Hammer NI, Fortenberry RC, Reinemann DN.   +6 more
europepmc   +1 more source

Immunomagnetic‐MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor‐Derived Exosomes

Advanced Science, EarlyView.
An immunomagnetic‐MXene bifunctional probe integrated with THz metamaterials enables ultrasensitive and specific detection of pancreatic cancer‐derived exosomes. Dual biomarker recognition ensures high specificity, while MXene signal amplification achieves a detection limit of 647 particles mL−1.
Weidong Jin, Jiyue Chen, Fengxin Xie, Huiyan Tian, Xuechen Dou, Yanqi Han, Lu Zhang, Jining Li, Xiang Yang   +8 more
wiley   +1 more source

Investigating the Function of C‑Terminal Tails of Human Tubulin Isotypes in the Motility Regulation of Cytoplasmic Dynein. [PDF]

ACS Omega
Garg J, Lopes Ribeiro J, Wallin S, Alisaraie L.   +3 more
europepmc   +1 more source

Intermittent Fasting Reduces Taurine Availability and Promotes Antitumor Immunity Through PERK Attenuation‐Associated Paraptosis‐Like Cell Death in Colorectal Cancer

Advanced Science, EarlyView.
This study identifies reduced taurine availability as a mediator of intermittent fasting in colorectal cancer and shows that taurine interacts with GRP78 to maintain PERK abundance post‐transcriptionally. It further shows that taurine depletion destabilizes PERK, induces immunogenic paraptosis, remodels the tumor microenvironment toward a CD8+ T cell ...
Baohui Song, Sikei Kam, Jingyi Liu, Rui Lv, Xucheng Huo, Zhanghan Chen, Yuelun Dong, Shilun Cai, Bing Li, Ruobing Ren, Yunshi Zhong, Mingyan Cai   +11 more
wiley   +1 more source

Population structure and punctuated genomic hyper-diversity in Caenorhabditis briggsae. [PDF]

Mol Biol Evol
Moya ND, Wang B, Tanny RE, Sauria MEG, O'Connor LM, Khorshidian A, McKeown R, Gosse C, Dilks CM, Crombie TA, Zhang G, Rais E, Frézal L, Dang VD, Haryoso E, Devi MP, Gimond C, Cook DE, Hsu JC, Shaver AO, Zdraljevic S, Richaud A, Wen T, Mehraj A, H S, Arulprakasam KR, Koury EJ, Roberto NM, Schaye ES, Singh V, Tarno H, Ailion M, Paaby AB, Zhao Z, Cutter AD, Wang J, Rockman MV, Félix MA, Braendle C, Andersen EC.   +39 more
europepmc   +1 more source

Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer

Advanced Science, EarlyView.
SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han, Tian‐Yuan Tan, Bin Zhang, Ye‐Bin Fu, Wen Chen, Min‐Hui Yang, Yi‐Qing Wang, Yan‐Qing Ding, Shuang Wang   +8 more
wiley   +1 more source

REPt₃Si (RE = La, Pr, Nd, Sm and Gd): isotypes of the heavy fermion superconductor CePt₃Si

, 2005
REPt₃Si (RE = La, Pr, Nd, Sm and Gd): isotypes of the heavy fermion superconductor ...
Sieberer, M., Rogl, Peter Franz, Bauer, Ernst, Gribanov, A., Michor, Herwig, Seropegin, Y, Hilscher, Gerfried, Lackner, Roman, Eichler, A.   +8 more
core  

Long-range allosteric communication within antibodies affects antigen-binding affinity. [PDF]

Front Immunol
Vester SK, Sutton BJ, McDonnell JM.
europepmc   +1 more source