Tissue distribution and pharmacokinetics of isoxanthohumol from hops in rodents. [PDF]
Food Sci Nutr, 2023 AbstractVegetables and fruits contain prenylflavonoids with biological functions that might improve human health. The prenylflavonoid isoxanthohumol (IXA) and its derivative, 8‐prenylnaringenin (8‐PN), have beneficial activities, including anti‐cancer effects and suppression of insulin resistance.
Mukai R, Hata N.
europepmc +5 more sources
Biotransformed Metabolites of the Hop Prenylflavanone Isoxanthohumol [PDF]
Molecules, 2019 A metabolic conversion study on microbes is known as one of the most useful tools to predict the xenobiotic metabolism of organic compounds in mammalian systems.
Hyun Jung Kim +9 more
doaj +3 more sources
Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; Conversion of isoxanthohumol into 8-prenylnaringenin [PDF]
Journal of Agricultural and Food Chemistry, 2005 Hop, an essential ingredient in most beers, contains a number of prenylflavonoids, among which 8-prenylnaringenin (8-PN) would be the most potent phytoestrogen currently known. Although a number of health effects are attributed to these compounds, only a
De Keukeleire, Denis +4 more
core +6 more sources
Prenylflavonoid Isoxanthohumol Sensitizes MCF-7/ADR Cells to Doxorubicin Cytotoxicity via Acting as a Substrate of ABCB1 [PDF]
Toxins, 2017 Isoxanthohumol is a unique prenylflavonoid with the highest content in beer. Isoxanthohumol has multiple bioactivities and has recently received considerable attention in the scientific community.
Ming Liu +5 more
doaj +3 more sources
Metabolomics analysis reveals serum biomarkers in patients with diabetic sarcopenia [PDF]
Frontiers in Endocrinology, 2023 IntroductionDiabetic sarcopenia (DS) is characterized by muscle atrophy, slower nerve conduction, reduced maximum tension generated by skeletal muscle contraction, and slower contraction rate. Hence, DS can cause limb movement degeneration, slow movement,
Yuwei Tan +28 more
doaj +2 more sources
Isoxanthohumol improves hepatic lipid metabolism via regulating the AMPK/PPARα and PI3K/AKT signaling pathways in hyperlipidemic mice. [PDF]
Food Sci NutrIsoxanthohumol significantly improves blood lipid levels, attenuates hepatic steatosis, and mitigates oxidative stress in hyperlipidemic mice. These beneficial effects are possibly attributed to the upregulation of the AMPK/PPARα and PI3K/AKT signaling pathways.
Gao Y +11 more
europepmc +2 more sources
Migration of Hop Polyphenols in Beer Technology: Model Solution for Various Hopping Methods [PDF]
Техника и технология пищевых производств, 2021 Introduction. The research featured the effect of various hopping conditions on the content of polyphenolic compounds associated with the extraction and biotransformation of hop compounds. This mechanism is responsible for uncharacteristic beer flavor in
Marina V. Gernet +4 more
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The Antifungal Mechanism of Isoxanthohumol from Humulus lupulus Linn. [PDF]
International Journal of Molecular Sciences, 2021 Humulus lupulus Linn. is a traditional medicinal and edible plant with several biological properties. The aims of this work were: (1) to evaluate the in vitro antifungal activity of H. lupulus ethanolic extract; (2) to study the in vitro and in vivo antifungal activity of isoxanthohumol, an isoprene flavonoid from H.
Yin-Fang Yan +8 more
openaire +2 more sources
Chemoprotective Effects of Xanthohumol against the Carcinogenic Mycotoxin Aflatoxin B1
Foods, 2021 The present study addresses the chemoprotective effects of xanthohumol (XN), a prenylated flavonoid found in the female inflorescences (hops) of the plant Humulus lupulus L., against the carcinogenic food contaminant aflatoxin B1 (AFB1).
Alja Štern +8 more
doaj +1 more source
Antioxidants, 2020 Both short- and long-term exposure to fine dust (FD) from air pollution has been linked to various cardiovascular diseases (CVDs). Endothelial cell (EC) senescence is an important risk factor for CVDs, and recent evidence suggests that FD-induced ...
Saugat Shiwakoti +6 more
doaj +1 more source