Results 251 to 260 of about 32,281 (298)

ChemInform Abstract: Ozonolysis of Substituted Isoxazoles.

ChemInform, 1994
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
K. Takahashi, Choji Kashima, Akira Hosomi   +2 more
openaire   +3 more sources

Synthesis of new isoxazole derivatives

Russian Journal of Organic Chemistry, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
N. N. Yusubov, M. M. Kantaeva, V. M. Ismailov, I. A. Mamedov   +3 more
openaire   +3 more sources

Discovery of a New Isoxazole-3-hydroxamate Based Histone Deacetylase 6 Inhibitor SS-208 with Anti-tumor Activity in Syngeneic Melanoma Mouse Models.

Journal of Medicinal Chemistry, 2019
Isoxazole is a five-membered heterocycle that is widely used in drug discovery endeavors. Here, we report the design, synthesis, and structural and biological characterization of SS-208, a novel HDAC6-selective inhibitor containing the isoxazole-3 ...
S. Shen, M. Hadley, K. Ustinova, J. Pavlicek, Tessa Knox, S. Noonepalle, M. T. Tavares, Chad A. Zimprich, Guiping Zhang, M. Robers, C. Bařinka, A. Kozikowski, A. Villagra   +12 more
semanticscholar   +1 more source

Studies in isoxazole chemistry. IV. Isoxazoles via isoxazolines

Canadian Journal of Chemistry, 1970
4- or 5-Chloro- or cyanoisoxazoles, 5-chloromethylisoxazoles, and 5-methylisoxazoles were made by the 1,3-dipolar cycloaddition of nitrile oxides to α-halogeno- or α-alkoxyolefins. In the case of cis- and trans-1,2-dichloroethylene, (5a and b) the intermediate cis- and trans-4,5-dichloroisoxalines (6a and b) were isolated.
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An asymmetric isoxazole annulation

Journal of Heterocyclic Chemistry, 1988
AbstractAn Asymmetric isoxazole annulation proceeds from the (S)‐O‐methoxyphenylalaninol imine of (RS)‐2‐phen‐ylpropionaldehyde (3). Deprotonation, quenching with 4‐chloromethyl‐3,5‐dimethylisoxazole, and hydrolysis produced isoxazolylaldehyde (5), whose structure was confirmed by single crystal X‐ray diffractometry. The absolute configuration of (‐)‐5
Ludwig Schlicksupp, Brian E. Marron, Nicholas R. Natale   +2 more
openaire   +3 more sources

An Efficient Synthesis of Isoxazoles and Isoxazolines [PDF]

HETEROCYCLES, 1985
AbstractDurch Umsetzung der, Hydroxamsäurechloride (III) mit Dipolarophilen wie (II), (IV) u.ä.
P. Caldirola, M. De Amici, C. De Micheli, P. Pevarello   +3 more
openaire   +2 more sources

Electronic structure of isoxazole

Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 1966
1. The scheme of the levels, the molecular diagram, and the indices of the reactivity of isoxazole were calculated by the simple LCAO MO method using the Huckel approximation. 2. Within the framework of the given approximation it was shown that for radical and nucleophilic substitution reactions the reactivity of the different positions ...
A. V. Tutkevich, Alexander A. Bagaturyants, D. A. Bochvar   +2 more
openaire   +2 more sources

Synthesis of Isoxazole Triflones

European Journal of Organic Chemistry, 2012
AbstractThe first practical synthesis of isoxazole triflones 3 (4‐trifluoromethanesulfonylisoxazoles, 4‐triflylisoxazoles) has been achieved by an operationally simple procedure consisting of the reaction between readily available α‐triflyl ketones 4 and imidoyl chlorides 5 in the presence of triethylamine.
Hiroyuki Kawai, Etsuko Tokunaga, Norio Shibata, Yutaka Sugita   +3 more
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Chromium (III) halide complexes with isoxazole and substituted isoxazoles as ligands

Spectrochimica Acta Part A: Molecular Spectroscopy, 1976
Abstract Complexes of chromium (III) with isoxazole, 3,5-dimethylisoxazole, 3-methyl, 5-phenylisoxazole and 3,5-diphenylisoxazole have been prepared and characterized by magnetic and spectroscopic techniques. lie stereochemistries of the complexes are discussed with emphasis on their i.r. spectra.
G. Tosi, Gustavo Ponticelli, Marcella Massacesi, C. Preti   +3 more
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Isoxazole Ionotropic Glutamate Neurotransmitters

Current Medicinal Chemistry, 2005
Analogs of the excitatory neurotransmitter glutamate are potential medicinal agents for a wide variety of neurological disorders. The isoxazole glutamate derivatives represent an important class of compounds because of their receptor specificity and binding affinity. Since the discovery of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid (
David J. Burkhart, Nicholas R. Natale
openaire   +3 more sources