Results 231 to 240 of about 20,504 (258)

Rapid Access to Benzimidazo[1,2-a]quinoline-Fused Isoxazoles via Pd(II)-Catalyzed Intramolecular Cross Dehydrogenative Coupling: Synthetic Versatility and Photophysical Studies.

Journal of Organic Chemistry, 2021
An efficient and atom-economical palladium-catalyzed intramolecular cross dehydrogenative coupling (CDC) reaction has been developed for the construction of highly π-conjugated benzimidazo[1,2-a]quinoline-fused isoxazole scaffolds using molecular oxygen ...
Subrata Sahoo, Shantanu Pal
semanticscholar   +1 more source

Recent Progress in the Synthesis of Isoxazoles

Current organic chemistry, 2021
Isoxazole derivatives are aromatic five-membered ring heterocyclic compounds with one oxygen atom and one nitrogen atom at adjacent positions.
D. Duc, V. C. Dung
semanticscholar   +1 more source

Unusual Reactivity of 4-Vinyl Isoxazoles in the Copper-Mediated Synthesis of Pyridines, Employing DMSO as a One-Carbon Surrogate.

Organic Letters, 2020
An efficient protocol for the synthesis of nicotinate derivatives and tetrasubstituted pyridines through a copper-mediated cleavage of isoxazoles has been developed.
Pravin Kumar, M. Kapur
semanticscholar   +1 more source

Photochemical and Electrochemical Synthesis of Oxazoles and Isoxazoles: An Update

Advanced Synthesis & Catalysis
This review presents an outline of current advancements in the photochemical and electrochemical synthesis of oxazoles and isoxazoles. Oxazole and isoxazole are important building blocks for a variety of medicinally useful compounds.
Debashis Ghosh, Ancy Sherin, Sumit Ghosh, Sushma A Kalose, A. Hajra   +4 more
semanticscholar   +1 more source

Visible-Light-Mediated Three-Component Strategy for the Synthesis of Isoxazolines and Isoxazoles.

Organic Letters
Isoxazolines and isoxazoles commonly serve as core structures of many therapeutic agents and natural products. However, the metal-free and catalysis-free strategy for the synthesis of these privileged motifs at room temperature remains a challenging task.
Yanchuan Li, Yu Zhang, Jinxin Wang, Dingding Xia, Miaomiao Zhuo, Lu Zhu, Dong Li, Shao‐Fei Ni, Yanping Zhu, Weidong Zhang   +9 more
semanticscholar   +1 more source

Synthesis of Furoxans and Isoxazoles via Divergent [2 + 1 + 1 + 1] Annulations of Sulfoxonium Ylides and tBuONO.

Organic Letters, 2019
We have presented a simple and new method for the divergent assembly of furoxans and isoxazoles in which the [2 + 1 + 1 + 1] annulation reaction of sulfoxonium ylides is reported for the first time.
Zhonghe Tang, Yao Zhou, Q. Song
semanticscholar   +1 more source

Zinc-Catalyzed Asymmetric Formal [4+3] Annulation of Isoxazoles with Enynol Ethers via 6π Electrocyclization: Stereoselective Access to 2H-Azepines.

Angewandte Chemie, 2019
6π electrocyclization has attracted considerable interest in organic synthesis because of its high stereospecificity and atom economy in the construction of versatile 5- to 7-membered cycles.
Xinhai Zhu, Ze‐Shu Wang, Bo Hou, Hao‐Wen Zhang, Chao Deng, L. Ye   +5 more
semanticscholar   +1 more source

Synthesis of Spiro[indole-3,5'-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles.

Journal of Organic Chemistry, 2019
An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4' H-spiro[indole-3,5'-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and ...
Alexander V Aksenov, D. Aksenov, N. A. Arutiunov, N. Aksenov, E. Aleksandrova, Zhenze Zhao, Liqin Du, A. Kornienko, M. Rubin   +8 more
semanticscholar   +1 more source

Iterative Assembly of Nitrile Oxides and Ynamides: Synthesis of Isoxazoles and Pyrroles.

Journal of Organic Chemistry, 2019
Described is an iterative assembly of nitrile oxides and ynamides for the synthesis of isoxazoles and pyrroles. The nitrile oxides could undergo Cu(I)-free cyclization with terminal ynamides for accessing isoxazoles, which could engage in another ...
Changwei Chen, Sunliang Cui
semanticscholar   +1 more source

Four-Component Reactions for the Synthesis of Perfluoroalkyl Isoxazoles

ACS Catalysis, 2019
A four-component strategy for the synthesis of the isoxazole skeleton is developed. The approach achieves the synthesis of perfluoroalkyl isoxazoles by using simple perfluoroalkyl reagents.
Yuanjin Chen, Liangkui Li, Xiao-qiang He, Zhiping Li   +3 more
semanticscholar   +1 more source