Results 271 to 280 of about 19,238 (306)
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Organic Letters, 2018
This work reports gold-catalyzed [4 + 1]-annulation reactions between 1,4-diyn-3-ols and isoxazoles or benzisoxazoles to yield pyrrole derivatives. The reaction chemoselectivity is controlled by an initial attack of an isoxazole at a less hindered alkyne
Rahul Dadabhau Kardile +3 more
semanticscholar +1 more source
This work reports gold-catalyzed [4 + 1]-annulation reactions between 1,4-diyn-3-ols and isoxazoles or benzisoxazoles to yield pyrrole derivatives. The reaction chemoselectivity is controlled by an initial attack of an isoxazole at a less hindered alkyne
Rahul Dadabhau Kardile +3 more
semanticscholar +1 more source
ACS Combinatorial Science, 2018
A series of both novel and reported combretastatin analogues, including diarylpyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles, were synthesized via improved protocols to evaluate their antimitotic antitubulin activity using in vivo sea urchin ...
M. Semenova +12 more
semanticscholar +1 more source
A series of both novel and reported combretastatin analogues, including diarylpyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles, were synthesized via improved protocols to evaluate their antimitotic antitubulin activity using in vivo sea urchin ...
M. Semenova +12 more
semanticscholar +1 more source
Chromium (III) halide complexes with isoxazole and substituted isoxazoles as ligands
Spectrochimica Acta Part A: Molecular Spectroscopy, 1976Abstract Complexes of chromium (III) with isoxazole, 3,5-dimethylisoxazole, 3-methyl, 5-phenylisoxazole and 3,5-diphenylisoxazole have been prepared and characterized by magnetic and spectroscopic techniques. lie stereochemistries of the complexes are discussed with emphasis on their i.r. spectra.
G. Tosi +3 more
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Isoxazole Ionotropic Glutamate Neurotransmitters
Current Medicinal Chemistry, 2005Analogs of the excitatory neurotransmitter glutamate are potential medicinal agents for a wide variety of neurological disorders. The isoxazole glutamate derivatives represent an important class of compounds because of their receptor specificity and binding affinity. Since the discovery of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid (
David J. Burkhart, Nicholas R. Natale
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Organic Letters, 2019
The synthesis of isoxazoles has been achieved in a continuous flow system composed of two reaction units: the Friedel-Crafts acylation of alkynes and the azide conjugate addition to the resulting β-chlorovinyl ketones followed by a photochemical-thermal ...
H. Koo, H. Kim, K. Oh
semanticscholar +1 more source
The synthesis of isoxazoles has been achieved in a continuous flow system composed of two reaction units: the Friedel-Crafts acylation of alkynes and the azide conjugate addition to the resulting β-chlorovinyl ketones followed by a photochemical-thermal ...
H. Koo, H. Kim, K. Oh
semanticscholar +1 more source
Synthetic Approaches to Nitro-Substituted Isoxazoles
Synthesis, 2019Nitro-substituted isoxazoles are of utmost interest both as versatile intermediates for targeted organic synthesis and as perspective bioactive compounds for drug development.
D. Vasilenko +3 more
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The coordination chemistry of isoxazoles
Coordination Chemistry Reviews, 1991Isoxazole-metal complexes are often postulated as intermediates in reactions of considerable synthetic utility, for example the reductive ring opening of isoxazoles. Several isoxazole-metal complexes have been reported and well characterized. However, an updated review of this chemistry is needed.
Mark S. Munsey, Nicholas R. Natale
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Organic Letters, 2019
The stereospecific synthesis of Z-enamides is described in this paper. For the first time, isoxazoles have been employed as electrophiles in C-H functionalization to afford thermodynamically less stable Z-enamides utilizing salicylaldehydes in an atom ...
Suvankar Debbarma, S. S. Bera, M. Maji
semanticscholar +1 more source
The stereospecific synthesis of Z-enamides is described in this paper. For the first time, isoxazoles have been employed as electrophiles in C-H functionalization to afford thermodynamically less stable Z-enamides utilizing salicylaldehydes in an atom ...
Suvankar Debbarma, S. S. Bera, M. Maji
semanticscholar +1 more source
Recent Developments in Isoxazole Chemistry
1963Publisher Summary This chapter reviews new investigations in the field of synthetic isoxazoles. Isoxazoles possess the properties of the aromatic system. The syntheses of isoxazole derivatives involving formation of the 1–5 and 2–3 bonds of the isoxazole ring, as well as formation of the 1–5 and 3–4 bonds of the ring are described in the chapter. The
Nikolay K. Kochetkov, S.D. Sokolov
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Structure of an isoxazole amino ester
Acta Crystallographica Section C Crystal Structure Communications, 19912'-(N-Methylamino)-2-methylpropyl 5-methyl-3-phenylisoxazole-4-carboxylate hydroiodide, C16H21N2O3+.I-, Mr = 416.26, orthorhombic, Pna21, a = 23.293 (7), b = 10.276 (3), c = 7.971 (1) A, V = 1908.0 (8) A3, Z = 4, Dx = 1.448 g cm-3, Mo K alpha, lambda = 0.71069 A, mu = 17.1 cm-1, F(000) = 832, T = 293 K, R = 0.0610 for 1846 unique observed reflections ...
Yousef R. Mirzaei +4 more
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