Results 271 to 280 of about 19,561 (308)

Four-Component Reactions for the Synthesis of Perfluoroalkyl Isoxazoles

ACS Catalysis, 2019
A four-component strategy for the synthesis of the isoxazole skeleton is developed. The approach achieves the synthesis of perfluoroalkyl isoxazoles by using simple perfluoroalkyl reagents.
Yuanjin Chen, Liangkui Li, Xiao-qiang He, Zhiping Li   +3 more
semanticscholar   +1 more source

Synthesis of Isoxazole Triflones

European Journal of Organic Chemistry, 2012
AbstractThe first practical synthesis of isoxazole triflones 3 (4‐trifluoromethanesulfonylisoxazoles, 4‐triflylisoxazoles) has been achieved by an operationally simple procedure consisting of the reaction between readily available α‐triflyl ketones 4 and imidoyl chlorides 5 in the presence of triethylamine.
Hiroyuki Kawai, Etsuko Tokunaga, Norio Shibata, Yutaka Sugita   +3 more
openaire   +3 more sources

An Efficient Synthesis of Isoxazoles and Isoxazolines [PDF]

HETEROCYCLES, 1985
AbstractDurch Umsetzung der, Hydroxamsäurechloride (III) mit Dipolarophilen wie (II), (IV) u.ä.
P. Caldirola, M. De Amici, C. De Micheli, P. Pevarello   +3 more
openaire   +2 more sources

Sea Urchin Embryo Model As a Reliable in Vivo Phenotypic Screen to Characterize Selective Antimitotic Molecules. Comparative evaluation of Combretapyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles as Tubulin-Binding Agents.

ACS Combinatorial Science, 2018
A series of both novel and reported combretastatin analogues, including diarylpyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles, were synthesized via improved protocols to evaluate their antimitotic antitubulin activity using in vivo sea urchin ...
M. Semenova, D. Demchuk, D. V. Tsyganov, N. B. Chernysheva, A. V. Samet, E. A. Silyanova, V. P. Kislyi, A. S. Maksimenko, A. E. Varakutin, L. Konyushkin, M. M. Raihstat, A. Kiselyov, V. Semenov   +12 more
semanticscholar   +1 more source

Gold-Catalyzed [4 + 1]-Annulation Reactions between 1,4-Diyn-3-ols and Isoxazoles To Construct a Pyrrole Core.

Organic Letters, 2018
This work reports gold-catalyzed [4 + 1]-annulation reactions between 1,4-diyn-3-ols and isoxazoles or benzisoxazoles to yield pyrrole derivatives. The reaction chemoselectivity is controlled by an initial attack of an isoxazole at a less hindered alkyne
Rahul Dadabhau Kardile, Balaji S. Kale, Pankaj Sharma, Rai‐Shung Liu   +3 more
semanticscholar   +1 more source

Isoxazole Ionotropic Glutamate Neurotransmitters

Current Medicinal Chemistry, 2005
Analogs of the excitatory neurotransmitter glutamate are potential medicinal agents for a wide variety of neurological disorders. The isoxazole glutamate derivatives represent an important class of compounds because of their receptor specificity and binding affinity. Since the discovery of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid (
David J. Burkhart, Nicholas R. Natale
openaire   +3 more sources

Chromium (III) halide complexes with isoxazole and substituted isoxazoles as ligands

Spectrochimica Acta Part A: Molecular Spectroscopy, 1976
Abstract Complexes of chromium (III) with isoxazole, 3,5-dimethylisoxazole, 3-methyl, 5-phenylisoxazole and 3,5-diphenylisoxazole have been prepared and characterized by magnetic and spectroscopic techniques. lie stereochemistries of the complexes are discussed with emphasis on their i.r. spectra.
G. Tosi, Gustavo Ponticelli, Marcella Massacesi, C. Preti   +3 more
openaire   +2 more sources

Continuous Flow Synthesis of Isoxazoles via Vinyl Azides from Friedel-Crafts Acylation of Alkynes: A Modulated Troubleshooting Optimization Approach.

Organic Letters, 2019
The synthesis of isoxazoles has been achieved in a continuous flow system composed of two reaction units: the Friedel-Crafts acylation of alkynes and the azide conjugate addition to the resulting β-chlorovinyl ketones followed by a photochemical-thermal ...
H. Koo, H. Kim, K. Oh
semanticscholar   +1 more source

The coordination chemistry of isoxazoles

Coordination Chemistry Reviews, 1991
Isoxazole-metal complexes are often postulated as intermediates in reactions of considerable synthetic utility, for example the reductive ring opening of isoxazoles. Several isoxazole-metal complexes have been reported and well characterized. However, an updated review of this chemistry is needed.
Mark S. Munsey, Nicholas R. Natale
openaire   +2 more sources

Synthetic Approaches to Nitro-Substituted Isoxazoles

Synthesis, 2019
Nitro-substituted isoxazoles are of utmost interest both as versatile intermediates for targeted organic synthesis and as perspective bioactive compounds for drug development.
D. Vasilenko, K. Sedenkova, T. Kuznetsova, E. Averina   +3 more
semanticscholar   +1 more source