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Spinal Calcrl+ neurons amplify mechanical itch signaling via synaptic plasticity in chronic itch model. [PDF]
PLoS ONEChronic itch, a devastating dermatological disorder, lacks targeted therapies due to incomplete understanding of its neural circuitry. Building on seminal studies that identified neuropeptide Y (NPY) inhibitory interneurons and their downstream urocortin
Huifeng Jiao +11 more
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Phase-Space Modeling and Control of Robots in the Screw Theory Framework Using Geometric Algebra
Mathematics, 2023 The following paper talks about the dynamic modeling and control of robot manipulators using Hamilton’s equations in the screw theory framework. The difference between the proposed work with diverse methods in the literature is the ease of obtaining the ...
Jesús Alfonso Medrano-Hermosillo +3 more
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Itch Beyond the Skin—Mucosal Itch [PDF]
Frontiers in Allergy, 2021 Itch is a nociceptive sensation linked with reflexes and cognitive motor actions. We traditionally think of itch as a sensation of the skin related to allergy, an insect sting or interestingly, anxiety and frustration. Less understood and considered are the physiological processes involved in the itching sensation that occurs at mucosal and junctional ...
Olivia J. Ly Lesslar +2 more
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Acta Dermato-Venereologica, 2023 Crisaborole, a phosphodiesterase 4 (PDE4) inhibitor, has been approved for the treatment of mild to moderate atopic dermatitis. Atopic dermatitis is often associated with increased pain.
Darya Pavlenko +6 more
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Cells, 2020 Neurologic insults as varied as inflammation, stroke, and fibromyalgia elicit neuropathic pain and itch. Noxious sensation results when aberrantly increased afferent signaling reaches percept-forming cortical neurons and can occur due to increased sensory signaling, decreased inhibitory signaling, or a combination of both processes.
James Meixiong +2 more
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Itch and neuropathic itch [PDF]
Pain, 2018 Abstract Neuropathic itch is a pathological condition that is due to damage within the nervous system. This type of itch can be severe and unrelenting, which has a very negative impact on quality of life. Neuropathic itch is more common than generally appreciated because most types of neuropathic pain have a neuropathic itch counterpart ...
Junichi, Hachisuka +2 more
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Nature Communications, 2020 The role of gastrin related peptide (GRP+) neurons in itch is debated. Here, the authors generate a conditional knock-in mouse to label and manipulate GRP expressing DRG neurons and investigate their role in itch and nociception.
Devin M. Barry +11 more
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Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review
Dermatology and Therapy, 2023 Chronic spontaneous urticaria (CSU) is a condition in which wheals, angioedema, and pruritus occur spontaneously and recurrently for at least 6 weeks. The etiology of this disease is partially dependent on production of autoantibodies that activate and ...
Gil Yosipovitch +2 more
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Frontiers in Medicine, 2022 Itch and pain are common after burns. Neuropathic mechanisms may underlie both modalities but remain not well-understood. This study aims to prospectively document neuropathic pain symptoms and to identify potential itch symptom profiles that differ ...
N. E. E. Van Loey +5 more
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A spinal neural circuitry for converting touch to itch sensation
Nature Communications, 2020 Light touch can sometimes induce unpleasant itch sensation but the neural correlates of this conversion are not well studied. Here, the authors provide evidence that Tac2 expressing spinal interneurons are connected to gastrin-releasing peptide receptor (
Sihan Chen +11 more
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