Results 41 to 50 of about 34,079 (294)

Activation of NPY2R-expressing amygdala neurons inhibits itch behavior in mice without lateralization

Scientific Reports
The central amygdala (CeA) is a crucial hub in the processing of affective itch, containing a diverse array of neuronal populations. Among these components, Neuropeptide Y (NPY) and its receptors, such as NPY2R, affect various physiological and ...
Darya Pavlenko, Zeynep Gizem Todurga-Seven, Kristen Sanders, Anika Markan, Rebecca Verpile, Hirotake Ishida, Dylan Costo, Tasuku Akiyama   +7 more
doaj   +1 more source

Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch.

PLoS ONE, 2011
BackgroundHistamine is the prototypical pruritogen used in experimental itch induction. However, in most chronic pruritic diseases, itch is not predominantly mediated by histamine.
Alexandru D P Papoiu, Hong Liang Tey, Robert C Coghill, Hui Wang, Gil Yosipovitch   +4 more
doaj   +1 more source

Circular RNA ITCH Is a Tumor Suppressor in Clear Cell Renal Cell Carcinoma Metastasis through miR-106b-5p/PDCD4 Axis

Journal of Immunology Research, 2021
High metastasis of clear cell renal cell carcinoma (ccRCC) significantly influenced survival rate of ccRCC patients. Here, we intended to investigate the impacts of circular RNA ITCH (circ-ITCH) on the metastasis of ccRCC.
Ping Gao, Yong Huang, Yanmei Hou, Qian Li, Haimei Wang   +4 more
doaj   +1 more source

Bringing on the itch

eLife, 2019
Neutrophils are the first immune cells that enter the skin and cause itch in atopic dermatitis.
Daniel A Waizman, Sourav Ghosh, Carla V Rothlin   +2 more
openaire   +4 more sources

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Evoked itch perception is associated with changes in functional brain connectivity

NeuroImage: Clinical, 2015
Chronic itch, a highly debilitating condition, has received relatively little attention in the neuroimaging literature. Recent studies suggest that brain regions supporting itch in chronic itch patients encompass sensorimotor and salience networks, and ...
Gaëlle Desbordes, Ang Li, Marco L. Loggia, Jieun Kim, Peter C. Schalock, Ethan Lerner, Thanh N. Tran, Johannes Ring, Bruce R. Rosen, Ted J. Kaptchuk, Florian Pfab, Vitaly Napadow   +11 more
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Pain and itch coding mechanisms of polymodal sensory neurons

Cell Reports, 2023
Summary: Pain and itch coding mechanisms in polymodal sensory neurons remain elusive. MrgprD+ neurons represent a major polymodal population and mediate both mechanical pain and nonhistaminergic itch. Here, we show that chemogenetic activation of MrgprD+
Changxiong Guo, Haowu Jiang, Cheng-Chiu Huang, Fengxian Li, William Olson, Weishan Yang, Michael Fleming, Guang Yu, George Hoekel, Wenqin Luo, Qin Liu   +10 more
doaj  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Neuropathic itch

Pain, 2019
Abstract Neuropathic itch is clinically important but has received much less attention as compared to neuropathic pain. In the past decade, itch-specific pathways have been characterized on a cellular and molecular level, but their exact role in the pathophysiology of neuropathic itch is still unclear.
Steinhoff M., Oaklander A.L., Szab I.L., Stnder S., Schmelz M.   +4 more
openaire   +4 more sources