Results 1 to 10 of about 47,734 (283)

Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction

Clinical and Translational Science, 2020
The oral bioavailability of ibrutinib is low and variable, mainly due to extensive first‐pass metabolism by cytochrome P450 (CYP) 3A4. The unpredictable exposure can compromise its safe and effective dosing.
Tuija Tapaninen, Aleksi M. Olkkola, Aleksi Tornio, Mikko Neuvonen, Erkki Elonen, Pertti J. Neuvonen, Mikko Niemi, Janne T. Backman   +7 more
doaj   +2 more sources

Exploring the therapeutic mechanism of itraconazole combined with ritonavir on Candida albicans infection through network pharmacology and molecular docking [PDF]

Frontiers in Pharmacology
BackgroundAutophagy induced by itraconazole and ritonavir was found involved in the pathogenesis of C. albicans. This study was designed to explore the possible molecular mechanism of itraconazole and ritonavir in the treatment of Candida albicans ...
Yiyang Feng, Wenli Feng, Jing Yang, Yan Ma   +3 more
doaj   +2 more sources

Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells

Journal of Experimental & Clinical Cancer Research, 2017
Background Itraconazole has been proved therapeutically effective against a variety of human cancers. This study assessed the effect of itraconazole on the Hedgehog (Hh) pathway and proliferation of human gastric cancer cells.
Qiang Hu, Yi-Chao Hou, Jiao Huang, Jing-Yuan Fang, Hua Xiong   +4 more
doaj   +2 more sources

Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis [PDF]

Scientific Reports
Candida onychomycosis is a common fungal nail infection where treatment efficacy can be compromised by antifungal resistance. This study investigates the role of efflux pump genes (CDR1, CDR2, and MDR1) and biofilm-associated genes (ALS1, ALS3) in ...
Hasti Nouraei, Neda Amirzadeh, Hossein Khodadadi, Mehdi Ghahartars, Zahra Zareshahrabadi, Reza Nasr, Seyed Jamal Hashemi, Kambiz Diba, Kamiar Zomorodian, Keyvan Pakshir   +9 more
doaj   +2 more sources

Chronic cavitary pulmonary histoplasmosis treated with isavuconazole after a hypersensitivity reaction to itraconazole [PDF]

Medical Mycology Case Reports
Chronic cavitary pulmonary histoplasmosis requires prolonged treatment with itraconazole. However, hypersensitivity reactions to itraconazole, though rare, pose a challenge due to limited data on the efficacy and cross-reactivity of the newer azoles.
Miguel E. Cervera-Hernandez, Sunit P. Jariwala   +1 more
doaj   +2 more sources

The anti-cancer effects of itraconazole in epithelial ovarian cancer

Scientific Reports, 2017
We assessed the anti-proliferative activity of itraconazole using an EOC cell line (SKOV3ip1) and endothelial cell lines (HUVEC & SVEC4-10). We also examined angiogenesis (VEGFR2, p-ERK, p-PLCr1/2), hedgehog (Gli1, Ptch1, SMO), and mTOR (pS6K1) signaling
Chel Hun Choi, Ji-Yoon Ryu, Young-Jae Cho, Hye-Kyung Jeon, Jung-Joo Choi, Kris Ylaya, Yoo-Young Lee, Tae-Joong Kim, Joon-Yong Chung, Stephen M. Hewitt, Byoung-Gie Kim, Duk-Soo Bae, Jeong-Won Lee   +12 more
doaj   +2 more sources

Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro [PDF]

Journal of Antimicrobial Chemotherapy, 2000
Microbroth dilution tests in vitro showed the same IC(50) values for itraconazole and hydroxy-itraconazole, within a mode +/- one dilution range of experimental error, for 90% of 1481 isolates of pathogenic fungi, representing 48 genera. Some 10-15% of Candida glabrata and Trichophyton mentagrophytes isolates were more susceptible to itraconazole than ...
Frank C. Odds, H. Vanden Bossche
openalex   +4 more sources

Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations [PDF]

Antimicrobial Agents and Chemotherapy, 2021
We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson’s r , 0.7838), and OH-ITZ levels were generally higher than ITZ levels (median OH-ITZ:ITZ ratio, 1.
Nathan P. Wiederhold, Ilan S. Schwartz, Thomas F. Patterson, George R. Thompson   +3 more
openaire   +5 more sources

475. Does Metabolite Matter? Defining Target Itraconazole and Hydroxy-itraconazole Serum Levels for Blastomycosis

Open Forum Infectious Diseases, 2022
Background Itraconazole is first-line treatment for mild-moderate blastomycosis and consolidation of moderate-severe disease. Itraconazole is metabolized to 3 metabolites, including an active metabolite hydroxy-itraconazole.
Danielle Hess, O. A. Abu Saleh, M. Enzler, P. Jannetto, Kristin Mara, Ryan W. Stevens, P. Vergidis, C. Rivera   +7 more
semanticscholar   +1 more source

Itraconazole Inhibits the Growth of Cutaneous Squamous Cell Carcinoma by Targeting HMGCS1/ACSL4 Axis

Frontiers in Pharmacology, 2022
Background: Cutaneous squamous cell carcinoma (cSCC) is a common cutaneous cancer with increasing incidence. Itraconazole has been identified as a potential anticancer drug candidate. However, the role of itraconazole in cSCC was still unclear.
Congcong Xu, Yating Zhuo, Yunyao Liu, Hao Chen   +3 more
doaj   +1 more source