Results 31 to 40 of about 48,863 (239)

Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non–Small Cell Lung Cancer

Clinical Cancer Research, 2020
Purpose: Itraconazole has been repurposed as an anticancer therapeutic agent for multiple malignancies. In preclinical models, itraconazole has antiangiogenic properties and inhibits Hedgehog pathway activity.
D. Gerber, W. Putnam, Farjana J Fattah, K. Kernstine, R. Brekken, I. Pedrosa, R. Skelton, Jessica M. Saltarski, R. Lenkinski, R. Leff, C. Ahn, Chyndhri Padmanabhan, Vaidehi Chembukar, S. Kasiri, R. Kallem, I. Subramaniyan, Qing Yuan, Quyen N. Do, Y. Xi, S. Reznik, Lorraine C Pelosof, B. Faubert, R. Deberardinis, James Kim   +23 more
semanticscholar   +1 more source

The Synergistic Effect of Tacrolimus (FK506) or Everolimus and Azoles Against Scedosporium and Lomentospora Species In Vivo and In Vitro

Frontiers in Cellular and Infection Microbiology, 2022
Scedosporium and Lomentospora infections in humans are generally chronic and stubborn. The use of azoles alone cannot usually inhibit the growth of these fungi.
Zikuo Wang, Mei Liu, Luyao Liu, Linyun Li, Lihua Tan, Yi Sun   +5 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Efficacy of oral terbinafine versus itraconazole in treatment of dermatophytic infection of skin – A prospective, randomized comparative study

Indian Journal of Pharmacology, 2019
OBJECTIVES: Dermatophytic infections are the common fungal infections aggravated by hot and humid climate. Terbinafine and itraconazole are commonly used oral antifungal agents for the same.
A. Bhatia, B. Kanish, D. Badyal, P. Kate, S. Choudhary   +4 more
semanticscholar   +1 more source

The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro and in vivo

Emerging Microbes and Infections, 2019
Influenza A virus (IAV) is a common pathogen of respiratory disease. The IAV-induced seasonal epidemics and the sporadic pandemics are associated with high morbidity and mortality.
S. Schloer, J. Goretzko, A. Kühnl, Linda Brunotte, S. Ludwig, U. Rescher   +5 more
semanticscholar   +1 more source

Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes

Journal of Toxicology, 2009
Itraconazole and fluconazole have been reported to induce hepatotoxicity in patients. The present study was designed to investigate the role of cytochrome P450 inhibitors, SKF 525A, and curcumin pretreatment on the cytotoxicity of antifungal drugs ...
Nhareet Somchit, Chong Sock Ngee, Azhar Yaakob, Zuraini Ahmad, Zainul Amiruddin Zakaria   +4 more
doaj   +1 more source

Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial

Dermatology Practical & Conceptual, 2016
Background: Few studies have examined the effect of seborrheic dermatitis (SD) and/or its consequent therapy on a patient’s quality of life. Itraconazole has been suggested as an effective therapy for severe SD but its impact on Quality of Life (QoL) in ...
Zaheer Abbas, Seyede Zahra Ghodsi, Robabeh Abedeni   +2 more
doaj   +1 more source

Repurposing Itraconazole Loaded PLGA Nanoparticles for Improved Antitumor Efficacy in Non-Small Cell Lung Cancers

Pharmaceutics, 2019
Itraconazole (ITR) is a broad-spectrum antifungal drug, which has been shown to possess some promising anticancer, anti-proliferative, and anti-angiogenic properties in some cancers, such as cancers of the lung, breast, and skin.
N. Alhakamy, Shadab Md
semanticscholar   +1 more source

Inhibition of CAL27 Oral Squamous Carcinoma Cell by Targeting Hedgehog Pathway With Vismodegib or Itraconazole

Frontiers in Oncology, 2020
Oral Squamous Cell Carcinoma (OSCC) presents an important challenge for the health systems worldwide. Thus, unraveling the biological mechanisms involved in OSCC pathogenesis is essential to the discovery of new drugs with anticancer potential.
Raíza Dias Freitas, Raíza Dias Freitas, Rosane Borges Dias, Rosane Borges Dias, Manuela Torres Andion Vidal, Manuela Torres Andion Vidal, Ludmila de Faro Valverde, Ludmila de Faro Valverde, Rafaela Gomes Alves Costa, Andresa Karen Andrade Damasceno, Caroline Brandi Schlaepfer Sales, Leonardo de Oliveira Siquara da Rocha, Mitermayer Galvão dos Reis, Mitermayer Galvão dos Reis, Milena Botelho Pereira Soares, Ricardo Della Coletta, Thiago Almeida Pereira, Daniel Pereira Bezerra, Clarissa Araújo Gurgel Rocha, Clarissa Araújo Gurgel Rocha, Clarissa Araújo Gurgel Rocha   +20 more
doaj   +1 more source

Effect of rifampin and itraconazole on the pharmacokinetics of zanubrutinib (a Bruton's tyrosine kinase inhibitor) in Asian and non-Asian healthy subjects

Cancer Chemotherapy and Pharmacology, 2019
Purpose Zanubrutinib (BGB-3111) is a potent Bruton’s tyrosine kinase inhibitor with promising clinical activity in B-cell malignancies. Zanubrutinib was shown to be mainly metabolized through cytochrome P450 3A (CYP3A) in vitro.
S. Mu, Zhiyu Tang, W. Novotny, M. Tawashi, Ta‐Kai Li, Y. Ou, S. Sahasranaman   +6 more
semanticscholar   +1 more source