Results 41 to 50 of about 46,843 (269)

Inhibition of CAL27 Oral Squamous Carcinoma Cell by Targeting Hedgehog Pathway With Vismodegib or Itraconazole

Frontiers in Oncology, 2020
Oral Squamous Cell Carcinoma (OSCC) presents an important challenge for the health systems worldwide. Thus, unraveling the biological mechanisms involved in OSCC pathogenesis is essential to the discovery of new drugs with anticancer potential.
Raíza Dias Freitas, Raíza Dias Freitas, Rosane Borges Dias, Rosane Borges Dias, Manuela Torres Andion Vidal, Manuela Torres Andion Vidal, Ludmila de Faro Valverde, Ludmila de Faro Valverde, Rafaela Gomes Alves Costa, Andresa Karen Andrade Damasceno, Caroline Brandi Schlaepfer Sales, Leonardo de Oliveira Siquara da Rocha, Mitermayer Galvão dos Reis, Mitermayer Galvão dos Reis, Milena Botelho Pereira Soares, Ricardo Della Coletta, Thiago Almeida Pereira, Daniel Pereira Bezerra, Clarissa Araújo Gurgel Rocha, Clarissa Araújo Gurgel Rocha, Clarissa Araújo Gurgel Rocha   +20 more
doaj   +1 more source

Effect of rifampin and itraconazole on the pharmacokinetics of zanubrutinib (a Bruton's tyrosine kinase inhibitor) in Asian and non-Asian healthy subjects

Cancer Chemotherapy and Pharmacology, 2019
Purpose Zanubrutinib (BGB-3111) is a potent Bruton’s tyrosine kinase inhibitor with promising clinical activity in B-cell malignancies. Zanubrutinib was shown to be mainly metabolized through cytochrome P450 3A (CYP3A) in vitro.
S. Mu, Zhiyu Tang, W. Novotny, M. Tawashi, Ta‐Kai Li, Y. Ou, S. Sahasranaman   +6 more
semanticscholar   +1 more source

Super bioavailable itraconazole and its place and relevance in recalcitrant dermatophytosis: Revisiting skin levels of itraconazole and minimum inhibitory concentration data

Indian Dermatology Online Journal, 2021
Itraconazole, is the most commonly prescribed oral antifungal agent in India, and has a low minimum inhibitory concentration as compared to other oral antifungals, and in conjunction with the markedly high skin levels, the drug should have a predictably ...
Kabir Sardana, Sinu Rose Mathachan
doaj   +1 more source

Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects

Clinical and Translational Science, 2023
Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of cancer, including non‐Hodgkin's lymphomas and solid tumors.
Masaya Tachibana, Shunji Matsuki, Yutaro Maekawa, Kana Kuroda, Takako Shimizu, Junko Tsutsumi, Hitoshi Ishizuka   +6 more
doaj   +1 more source

Comparison of Efficacy and Safety between Super-bioavailable Itraconazole and Conventional Itraconazole in the Treatment of Tinea Infection of Glabrous Skin – A Randomised Observer-blinded Pilot Study

Journal of Pure and Applied Microbiology, 2023
Itraconazole is now being used as the first line drug for dermatophytosis. Complete clinical and mycological cure are not achieved in some cases. The Super Bioavailable (SB) formulation is being marketed as a better formulation of drug in terms of ...
Liza Mohapatra, Nibedita Dixit, Ishan Agrawal, Bikash Ranjan Kar, Bhabani S.T.P. Singh   +4 more
doaj   +1 more source

Itraconazole targets cell cycle heterogeneity in colorectal cancer

Journal of Experimental Medicine, 2018
Cellular dormancy and heterogeneity in cell cycle length provide important explanations for treatment failure after adjuvant therapy with S-phase cytotoxics in colorectal cancer (CRC), yet the molecular control of the dormant versus cycling state remains
S. Buczacki, S. Popova, E. Biggs, Chrysa Koukorava, Jon N. Buzzelli, L. Vermeulen, L. Hazelwood, Hayley E. Francies, M. Garnett, D. Winton   +9 more
semanticscholar   +1 more source

Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives

ChemMedChem, EarlyView.
Based on previously identified antimalarial agents, a series of highly substituted pyrazole and pyrimidines derivatives has been synthesized and tested for antiplasmodial and antileishmanial activity. Selected derivatives show promising antiplasmodial effect with a predicted favorable pharmacokinetic profile.
Matteo Lusardi, Nicoletta Basilico, Erika Iervasi, Chiara Brullo, Silvia Parapini, Marco Ponassi, Camillo Rosano, Andrea Spallarossa   +7 more
wiley   +1 more source

Itraconazole in dermatology

Journal of Dermatological Treatment, 1992
Itraconazole is a triazole analogue with a broad spectrum of antifungal activity, which covers yeasts and moulds. It is active against dermatophytes, candidal and pityrosporum yeasts, as well as a number of fungi which cause subcutaneous and systemic infection. It is well absorbed and has significantly fewer side-effects than systemic imidazoles. It is
openaire   +3 more sources

In vitro and in vivo antimicrobial effects of domiphen combined with itraconazole against Aspergillus fumigatus

Frontiers in Microbiology, 2023
Aspergillus fumigatus, a prevalent saprophytic fungus in the atmosphere, is known to rapidly induce severe invasive aspergillosis (IA) upon inhalation of its conidia by humans or animals. The mortality rate associated with IA exceeds 50%.
Huan Yang, Huan Yang, Yufan Gu, Yufan Gu, Zhiqiang He, Zhiqiang He, Jia-Nan Wu, Jia-Nan Wu, Chen Wu, Chen Wu, Yuhan Xie, Yuhan Xie, Yuxin You, Yuxin You, Yijia Yang, Yijia Yang, Xinyu Zhou, Xinyu Zhou, Yi Liu, Yi Liu, Wenlong Du, Wenlong Du   +21 more
doaj   +1 more source

Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis

Scientific Reports, 2018
Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats
Elaine Waite de Souza, C. Borba, S. Pereira, I. D. Gremião, I. Langohr, M. Oliveira, R. D. de Oliveira, Camila Rocha da Cunha, R. Zancopé-Oliveira, L. D. de Miranda, R. Menezes   +10 more
semanticscholar   +1 more source