Results 41 to 50 of about 48,863 (239)

Efficacy and safety of adding low-dose isotretinoin to itraconazole in the treatment of chronic recurrent dermatophytosis among sample of Iraqi patients: An open-labelled therapeutic clinical comparative study

Indian Journal of Dermatology, 2022
Background: An increasing number of dermatophytosis is seen now in daily clinical practice, with unusual presentations, running a chronic recurrent course and seems to be more resistant to systemic and topical conventional treatments, which necessitate ...
Dooha K Alhamdi, Khalil I Alhamdi
doaj   +1 more source

Antifungal Susceptibility Pattern of Non - Dermatophytic Fungi Causing Onychomycosis

Nepal Journal of Dermatology, Venereology & Leprology, 2020
Introduction: Non-dermatophytic molds (NDM) are filamentous fungi or yeast, commonly found in nature as saprophytes and plant pathogens. The incidence of onychomycosis due to NDM is 1.45 – 16.6%.
Apurva Kaushal, Pratik Gahalaut, R K Goyal, Neni Agarwal, Nitin Mishra, Madhur Kant Rastogi   +5 more
doaj   +3 more sources

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Aloe vera–Based Green Synthesis of Silver Nanoparticles With Characterization, Potent Antibacterial and Antioxidant Properties

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Green synthesis has emerged as a suitable alternative to the traditional method for manufacturing nanoparticles (NPs) as it provides a safer, sustainable, healthy, and environmental path for the NPs synthesis. Silver nanoparticles (AgNPs) were prepared using a green method with locally sourced Aloe vera leaf extract.
Janaki Baral, Sushant Timalsina, Sujan Dhungana, Laxmi Tiwari, Devendra Khadka, Bhoj Raj Poudel   +5 more
wiley   +1 more source

PENGARUH KOMBINASI EKSTRAK KULIT BUAH DURIAN DAN ITRACONAZOLE DALAM MENGHAMBAT PERTUMBUHAN Candida albicans

Cakradonya Dental Journal, 2019
Itraconazole merupakan salah satu obat sintetik yang memiliki keterbatasan dalam menghambat pertumbuhan Candida albicans (C. albicans). Kulit buah durian (Durio zibethinus L.) merupakan salah satu tanaman yang memiliki efek antifungal karena mengandung ...
Siti Rusdiana Puspa Dewi, Lizzana Farianty, Ahdiyat Sukmawan   +2 more
doaj   +1 more source

Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib

British Journal of Clinical Pharmacology, EarlyView.
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang, Yunlan Fang, Phillip Wang, Xiang Liu, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

Comparison of Efficacy and Safety between Super-bioavailable Itraconazole and Conventional Itraconazole in the Treatment of Tinea Infection of Glabrous Skin – A Randomised Observer-blinded Pilot Study

Journal of Pure and Applied Microbiology, 2023
Itraconazole is now being used as the first line drug for dermatophytosis. Complete clinical and mycological cure are not achieved in some cases. The Super Bioavailable (SB) formulation is being marketed as a better formulation of drug in terms of ...
Liza Mohapatra, Nibedita Dixit, Ishan Agrawal, Bikash Ranjan Kar, Bhabani S.T.P. Singh   +4 more
doaj   +1 more source

Itraconazole targets cell cycle heterogeneity in colorectal cancer

Journal of Experimental Medicine, 2018
Cellular dormancy and heterogeneity in cell cycle length provide important explanations for treatment failure after adjuvant therapy with S-phase cytotoxics in colorectal cancer (CRC), yet the molecular control of the dormant versus cycling state remains
S. Buczacki, S. Popova, E. Biggs, Chrysa Koukorava, Jon N. Buzzelli, L. Vermeulen, L. Hazelwood, Hayley E. Francies, M. Garnett, D. Winton   +9 more
semanticscholar   +1 more source

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects

Clinical and Translational Science, 2023
Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of cancer, including non‐Hodgkin's lymphomas and solid tumors.
Masaya Tachibana, Shunji Matsuki, Yutaro Maekawa, Kana Kuroda, Takako Shimizu, Junko Tsutsumi, Hitoshi Ishizuka   +6 more
doaj   +1 more source