Results 51 to 60 of about 48,863 (239)

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

In vitro and in vivo antimicrobial effects of domiphen combined with itraconazole against Aspergillus fumigatus

Frontiers in Microbiology, 2023
Aspergillus fumigatus, a prevalent saprophytic fungus in the atmosphere, is known to rapidly induce severe invasive aspergillosis (IA) upon inhalation of its conidia by humans or animals. The mortality rate associated with IA exceeds 50%.
Huan Yang, Huan Yang, Yufan Gu, Yufan Gu, Zhiqiang He, Zhiqiang He, Jia-Nan Wu, Jia-Nan Wu, Chen Wu, Chen Wu, Yuhan Xie, Yuhan Xie, Yuxin You, Yuxin You, Yijia Yang, Yijia Yang, Xinyu Zhou, Xinyu Zhou, Yi Liu, Yi Liu, Wenlong Du, Wenlong Du   +21 more
doaj   +1 more source

Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis

Scientific Reports, 2018
Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats
Elaine Waite de Souza, C. Borba, S. Pereira, I. D. Gremião, I. Langohr, M. Oliveira, R. D. de Oliveira, Camila Rocha da Cunha, R. Zancopé-Oliveira, L. D. de Miranda, R. Menezes   +10 more
semanticscholar   +1 more source

The Rare Presentation of Deep Dermatophytosis‐Trichophyton in an Immunosuppressed Patient

JEADV Clinical Practice, EarlyView.
ABSTRACT Dermatophytes typically cause superficial skin infections characterized by an active border. However, they can present atypically invading deeper in immunocompromised patients. We present a case of a 72‐year‐old woman with bullous pemphigoid who had received oral prednisolone for 3 months and developed umbilicated papules.
Jidapa Triwatcharikorn, Nitina Yeesibsean, Jirapon Jesrichai, Chanat Kumtornrut   +3 more
wiley   +1 more source

The Efficacy and Safety of Miconazole Nitrate Mucoadhesive Tablets versus Itraconazole Capsules in the Treatment of Oral Candidiasis: An Open-Label, Randomized, Multicenter Trial. [PDF]

PLoS ONE, 2016
Oral candidiasis (OC) is a common oral fungal infection. Recently, miconazole mucoadhesive tablets have been gaining attention for OC treatment. Despite trials in patients with human immunodeficiency virus and cancer, evidence of its application in the ...
Zhimin Yan, Xiaosong Liu, Yang Liu, Ying Han, Mei Lin, Wenmei Wang, Xiaobing Guan, Shengrong Zhu, Handong Zhang, Qintao Wang, Lihong Chou, Xinghao Zhu, Hong Hua   +12 more
doaj   +1 more source

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

ACS Chemical Biology, 2017
The antifungal drug itraconazole was recently found to exhibit potent antiangiogenic activity and has since been repurposed as an investigational anticancer agent. Itraconazole has been shown to exert its antiangiogenic activity through inhibition of the
S. Head, W. Shi, E. Yang, Benjamin A. Nacev, S. Y. Hong, K. Pasunooti, Ruo-Jing Li, J. Shim, Jun O. Liu   +8 more
semanticscholar   +1 more source

Use of Pinus sylvestris L. (Pinaceae), Origanum vulgare L. (Lamiaceae), and Thymus vulgaris L. (Lamiaceae) essential oils and their main components to enhance itraconazole activity against azole susceptible/not-susceptible Cryptococcus neoformans strains

BMC Complementary and Alternative Medicine, 2018
BackgroundCryptococcal infections, besides being a problem for immunocompromised patients, are occasionally being a problem for immunocompetent patients.
D. Scalas, N. Mandras, J. Roana, Roberta Tardugno, A. Cuffini, V. Ghisetti, S. Benvenuti, V. Tullio   +7 more
semanticscholar   +1 more source

Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways

OncoTarget, 2017
Malignant melanoma is the deadliest form of all skin cancers. Itraconazole, a commonly used systemic antifungal drug, has been tested for its anti-tumor effects on basal cell carcinoma, prostate cancer, and non-small cell lung cancer.
Guanzhao Liang, Musang Liu, Qiong Wang, Yong-nian Shen, Huan Mei, Dongmei Li, Weida Liu   +6 more
semanticscholar   +1 more source

Health‐Related Quality of Life in Stevens‐Johnson Syndrome and Toxic Epidermal Necrolysis: A Qualitative Study

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Epidermal necrolysis (EN), including Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are severe cutaneous drug reactions with high morbidity. However, the quality of life (QoL) impact during acute hospitalization is not well understood.
Jacob McFeeters, Allison Yan, Cole Veliky, Matthew Gallardo, Kelsey Nusbaum, Rachel Kirven, Kristopher Fisher, Abraham Korman, Hyoshin Kim, Benjamin H. Kaffenberger   +9 more
wiley   +1 more source

Repurposing itraconazole for the treatment of cancer.

Oncology Letters, 2017
The repurposing of drugs is becoming increasingly attractive as it avoids the lengthy process and cost implications associated with bringing a novel drug to market. Itraconazole is a broad-spectrum anti-fungal agent. An emerging body of in vivo, in vitro
R. Pounds, Sarah M. Leonard, C. Dawson, S. Kehoe   +3 more
semanticscholar   +1 more source