Results 51 to 60 of about 46,843 (269)

Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fruquintinib (FRUZAQLATM) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3). Two Phase 1, open‐label, single‐dose studies investigated the impact of hepatic or renal impairment on the pharmacokinetics and tolerability of fruquintinib.
Martha Gonzalez, Zhao Yang, William Schelman, Thomas C. Marbury, Juan C. Rondon, William Smith, Xiaofei Zhou, Neeraj Gupta, Caly Chien   +8 more
wiley   +1 more source

PENGARUH KOMBINASI EKSTRAK KULIT BUAH DURIAN DAN ITRACONAZOLE DALAM MENGHAMBAT PERTUMBUHAN Candida albicans

Cakradonya Dental Journal, 2019
Itraconazole merupakan salah satu obat sintetik yang memiliki keterbatasan dalam menghambat pertumbuhan Candida albicans (C. albicans). Kulit buah durian (Durio zibethinus L.) merupakan salah satu tanaman yang memiliki efek antifungal karena mengandung ...
Siti Rusdiana Puspa Dewi, Lizzana Farianty, Ahdiyat Sukmawan   +2 more
doaj   +1 more source

Use of Pinus sylvestris L. (Pinaceae), Origanum vulgare L. (Lamiaceae), and Thymus vulgaris L. (Lamiaceae) essential oils and their main components to enhance itraconazole activity against azole susceptible/not-susceptible Cryptococcus neoformans strains

BMC Complementary and Alternative Medicine, 2018
BackgroundCryptococcal infections, besides being a problem for immunocompromised patients, are occasionally being a problem for immunocompetent patients.
D. Scalas, N. Mandras, J. Roana, Roberta Tardugno, A. Cuffini, V. Ghisetti, S. Benvenuti, V. Tullio   +7 more
semanticscholar   +1 more source

Osimertinib Cost Minimization in Non‐Small Cell Lung Cancer (NSCLC) Treatment: Hypothesis Generation for a Population Pharmacokinetic Approach for Equivalent Dose Optimization of Osimertinib in Combination With Cobicistat

The Journal of Clinical Pharmacology, EarlyView.
Abstract Pharmacokinetic boosting can be a strategy to enhance osimertinib exposure and reduce treatment associated costs. The OSIBOOST trial demonstrated that it was feasible to boost low osimertinib plasma trough levels with cobicistat. The current study aims to establish the equivalent dose of cobicistat boosted osimertinib compared to osimertinib ...
Niels Westra, Paul D. Kruithof, Sander Croes, Robin M. J. M. van Geel, Lizza E. L. Hendriks, Daan J. Touw, Jos G. W. Kosterink, Jasper Stevens, Thijs H. Oude Munnink, Paola Mian   +9 more
wiley   +1 more source

The Efficacy and Safety of Miconazole Nitrate Mucoadhesive Tablets versus Itraconazole Capsules in the Treatment of Oral Candidiasis: An Open-Label, Randomized, Multicenter Trial. [PDF]

PLoS ONE, 2016
Oral candidiasis (OC) is a common oral fungal infection. Recently, miconazole mucoadhesive tablets have been gaining attention for OC treatment. Despite trials in patients with human immunodeficiency virus and cancer, evidence of its application in the ...
Zhimin Yan, Xiaosong Liu, Yang Liu, Ying Han, Mei Lin, Wenmei Wang, Xiaobing Guan, Shengrong Zhu, Handong Zhang, Qintao Wang, Lihong Chou, Xinghao Zhu, Hong Hua   +12 more
doaj   +1 more source

Primary Cutaneous Cryptococcosis due to Cryptococcus neoformans in an Immunocompetent Host Treated with Itraconazole and Drainage: Case Report and Review of the Literature

Case Reports in Dermatology, 2021
Cryptococcus neoformans is an opportunistic germ, usually causing infections in immunocompromised patients. The main sources of infection with C. neoformans are excrement from birds, decomposing wood, fruit, and vegetables.
Elizabeth Gaviria Morales, Marco Guidi, Tomas Peterka, Andrea Rabufetti, Roland Blum, Carlo Mainetti   +5 more
doaj   +1 more source

Impact of Drug-Rich Colloids of Itraconazole and HPMCAS on Membrane Flux in Vitro and Oral Bioavailability in Rats.

Molecular Pharmaceutics, 2017
Improving the oral absorption of compounds with low aqueous solubility is a common challenge that often requires an enabling technology. Frequently, oral absorption can be improved by formulating the compound as an amorphous solid dispersion (ASD).
Aaron M. Stewart, Michael E Grass, T. Brodeur, Aaron K. Goodwin, M. Morgen, D. T. Friesen, David T. Vodak   +6 more
semanticscholar   +1 more source

Unexpected Perseverance in Tinea Corporis – Special Mutations Found in Trichophyton indotineae Dermatomycosis

JEADV Clinical Practice, EarlyView.
ABSTRACT We hereby present the case of a patient with tinea incognita, who had received treatment with glucocorticosteroids and antibiotics for several months. Further diagnostic testing identified Trichophyton indotineae as the pathogen causing tinea corporis and cruris. The Erg1 gene encoding squalene epoxidase showed wild‐type information; therefore,
Deborah M. Gregersen, Nadine Berstecher, Anke Burmester, Jörg Tittelbach, Cornelia Wiegand   +4 more
wiley   +1 more source

Role of itraconazole in haematology/oncology [PDF]

Archives of Disease in Childhood, 2003
The antifungal agents most frequently used in prophylaxis and treatment are amphotericin B (and its new lipid forms) and azoles such as fluconazole, itraconazole, and more recently voriconazole. This review assesses the role of itraconazole in paediatric haematology/oncology practice.
Pandya, N. A., Atra, A. A., Riley, U., Pinkerton, C. R.   +3 more
openaire   +4 more sources

Cytotoxicity of Cultured Canine Primary Hepatocytes Exposed to Itraconazole Is Decreased by Pre-treatment With Glutathione

Frontiers in Veterinary Science, 2021
Objective: To identify the effect of glutathione (GSH) on cell survival in a novel in vitro model of itraconazole (ITZ)-associated hepatotoxicity using canine primary hepatocytes.Sample: Commercially sourced, cryopreserved male dog (Beagle) primary ...
Natalie M. Kirk, Natalie M. Kirk, Miranda D. Vieson, Kim A. Selting, Jennifer M. Reinhart   +4 more
doaj   +1 more source