Results 51 to 60 of about 47,734 (283)

Physiologically Based Pharmacokinetic Modeling of Valemetostat to Inform Dose Recommendations When Coadministered With CYP3A/P‐gp Modulators [PDF]

Clin Transl Sci
ABSTRACT Valemetostat tosylate (valemetostat) is an oral, potent, selective dual inhibitor of enhancer of zeste homolog (EZH)2 and EZH1, approved in Japan for the treatment of relapsed/refractory adult T‐cell leukemia/lymphoma and peripheral T‐cell lymphoma.
Watanabe A, Okudaira N, Tachibana M, Kazui M, Kotsuma M, Shimizu T, Lau Y.   +6 more
europepmc   +2 more sources

Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis

Scientific Reports, 2018
Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats
Elaine Waite de Souza, C. Borba, S. Pereira, I. D. Gremião, I. Langohr, M. Oliveira, R. D. de Oliveira, Camila Rocha da Cunha, R. Zancopé-Oliveira, L. D. de Miranda, R. Menezes   +10 more
semanticscholar   +1 more source

Challenges in optimizing tacrolimus therapy in patients treated with rifampin: A case series

British Journal of Clinical Pharmacology, EarlyView.
Tacrolimus is a cornerstone immunosuppressant in transplantation medicine with a narrow therapeutic window. Drug–drug interactions with strong CYP3A4 and P‐glycoprotein modulators, such as rifampin and azole antifungals, significantly alter tacrolimus exposure and complicate therapy. Two transplant cases illustrates the impact of rifampin on tacrolimus
Jeroen P. A. Houwen, Aurelia H. M. de Vries Schultink, Bas J. M. Peters, Dieuwertje Ruigrok, Rob H. J. Schönwetter, Esther V. Uijtendaal, Maaike A. Sikma   +6 more
wiley   +1 more source

PENGARUH KOMBINASI EKSTRAK KULIT BUAH DURIAN DAN ITRACONAZOLE DALAM MENGHAMBAT PERTUMBUHAN Candida albicans

Cakradonya Dental Journal, 2019
Itraconazole merupakan salah satu obat sintetik yang memiliki keterbatasan dalam menghambat pertumbuhan Candida albicans (C. albicans). Kulit buah durian (Durio zibethinus L.) merupakan salah satu tanaman yang memiliki efek antifungal karena mengandung ...
Siti Rusdiana Puspa Dewi, Lizzana Farianty, Ahdiyat Sukmawan   +2 more
doaj   +1 more source

Comparison of Efficacy and Safety between Super-bioavailable Itraconazole and Conventional Itraconazole in the Treatment of Tinea Infection of Glabrous Skin – A Randomised Observer-blinded Pilot Study

Journal of Pure and Applied Microbiology, 2023
Itraconazole is now being used as the first line drug for dermatophytosis. Complete clinical and mycological cure are not achieved in some cases. The Super Bioavailable (SB) formulation is being marketed as a better formulation of drug in terms of ...
Liza Mohapatra, Nibedita Dixit, Ishan Agrawal, Bikash Ranjan Kar, Bhabani S.T.P. Singh   +4 more
doaj   +1 more source

Use of Pinus sylvestris L. (Pinaceae), Origanum vulgare L. (Lamiaceae), and Thymus vulgaris L. (Lamiaceae) essential oils and their main components to enhance itraconazole activity against azole susceptible/not-susceptible Cryptococcus neoformans strains

BMC Complementary and Alternative Medicine, 2018
BackgroundCryptococcal infections, besides being a problem for immunocompromised patients, are occasionally being a problem for immunocompetent patients.
D. Scalas, N. Mandras, J. Roana, Roberta Tardugno, A. Cuffini, V. Ghisetti, S. Benvenuti, V. Tullio   +7 more
semanticscholar   +1 more source

Enhanced Vatiquinone Bioavailability With Fatty Meals and Optimal Dosing Schedule

Biopharmaceutics &Drug Disposition, EarlyView.
This investigation discusses two clinical studies. One investigated the effect of fatty meals (≥ 25% fat) on vatiquinone PK exposures, and the other one characterized vatiquinone PK profiles when administered on a TID dosing regimen corresponding to mealtimes. The data support the recommendation of administering vatiquinone with fatty meals (≥ 25% fat)
Lucy Lee, Katsuyuki Murase, Martin Thoolen, Peter Giannousis, Diksha Kaushik, Lee Golden, Ronald Kong   +6 more
wiley   +1 more source

Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects

Clinical and Translational Science, 2023
Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of cancer, including non‐Hodgkin's lymphomas and solid tumors.
Masaya Tachibana, Shunji Matsuki, Yutaro Maekawa, Kana Kuroda, Takako Shimizu, Junko Tsutsumi, Hitoshi Ishizuka   +6 more
doaj   +1 more source

Super bioavailable itraconazole and its place and relevance in recalcitrant dermatophytosis: Revisiting skin levels of itraconazole and minimum inhibitory concentration data

Indian Dermatology Online Journal, 2021
Itraconazole, is the most commonly prescribed oral antifungal agent in India, and has a low minimum inhibitory concentration as compared to other oral antifungals, and in conjunction with the markedly high skin levels, the drug should have a predictably ...
Kabir Sardana, Sinu Rose Mathachan
doaj   +1 more source

Role of itraconazole in haematology/oncology [PDF]

Archives of Disease in Childhood, 2003
The antifungal agents most frequently used in prophylaxis and treatment are amphotericin B (and its new lipid forms) and azoles such as fluconazole, itraconazole, and more recently voriconazole. This review assesses the role of itraconazole in paediatric haematology/oncology practice.
Pandya, N. A., Atra, A. A., Riley, U., Pinkerton, C. R.   +3 more
openaire   +4 more sources