Results 81 to 90 of about 47,734 (283)

Maculopapular eruption secondary to itraconazole

Collegium antropologicum, 2008
Adverse cutaneous reactions to itraconazole are known to be quite rare. We report a case of maculopapular reaction caused by itraconazole. On the 7th day of itraconazole therapy for hand onychomycosis, in a 39-year-old woman pruritus occurred with a subsequent morbiliform, symmetric, maculopapular eruption on the upper torso, neck, trunk and pressure ...
Batinac, Tanja, Zamolo, Gordana, Trošelj-Vukić, Biserka, Biljan, Darko, Petranović, Duška, Kujundžić, Milodar   +5 more
openaire   +7 more sources

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, EarlyView.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

Successful treatment of breakthrough disseminated Trichosporon asahii fungemia in a patient with acute myeloid leukemia receiving itraconazole prophylaxis

Medical Mycology Case Reports, 2018
We encountered a case of a 73-year-old man with acute myeloid leukemia who developed Trichosporon asahii systemic infection while on itraconazole prophylaxis during severe neutropenia. Cryptococcal antigen was useful for diagnosis.
Daiki Karigane, Masatoshi Sakurai, Emiko Matsuyama, Kentaro Ide, Sakiko Yamamoto-Takeuchi, Toyoko Inazumi, Sumiko Kohashi   +6 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions

Drug Metabolism And Disposition, 2018
Physiologically based pharmacokinetic (PBPK) modeling for itraconazole using a bottom-up approach is challenging, not only due to complex saturable pharmacokinetics (PK) and the presence of three metabolites exhibiting CYP3A4 inhibition, but also because
Luna Prieto Garcia, D. Janzén, Kajsa P. Kanebratt, H. Ericsson, H. Lennernäs, A. Lundahl   +5 more
semanticscholar   +1 more source

Nail Lichen Planus in 81 Patients: A Retrospective Study of Clinical Characteristics, Histopathological Features, and Long‐Term Treatment Outcomes

The Journal of Dermatology, EarlyView.
ABSTRACT Nail lichen planus (NLP) is a rare, chronic inflammatory nail disorder that can result in irreversible damage. While clinical awareness is growing, long‐term real‐world data—particularly incorporating histopathological confirmation and treatment outcomes—remains limited.
Juan He, Tengyu Weng, Jia Bai, Wenwei Zhu, Xingyu Huang, Yi Yang, Chengxin Li   +6 more
wiley   +1 more source

Observational study of the recent efficacy and economy of itraconazole vs. voriconazole in perioperative pulmonary aspergillosis

Frontiers in Surgery
BackgroundAntifungal therapy is a common treatment option for pulmonary aspergillosis, but its use to prevent recurrence and relieve symptoms in patients with pulmonary aspergillosis remains controversial.
Peng Chen, Xiao Zhang, Xinzhe Zheng, Yang Tang, Yongxiang Song, Gang Xu, Xixian Ke, Cheng Chen   +7 more
doaj   +1 more source

Emerging Terbinafine Resistant Trichophyton Dermatophytosis, Testing Options and Alternative Treatments: A Systematic Review

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Dermatophytosis is a common superficial fungal infection of the skin, most often caused by dermatophytes from the Trichophyton genus. Terbinafine, which inhibits squalene epoxidase (SQLE), is widely used as first line treatment. However, resistance to terbinafine is increasing globally, including recent reports in Australia, with origins ...
Thuvarahan Jegathees, Zachary P. Holmes, Catherine Martin, Cindy Kalai, Catherine Voutier, Denis Spelman, Gemma Robertson, Johannes S. Kern   +7 more
wiley   +1 more source

Breast and Nipple Dermatoses During Lactation

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Lactation and breastfeeding can present both psychological and physical challenges for breastfeeding mothers. In addition, many nursing mothers will also suffer from breast and nipple dermatoses during this period, compounding these difficulties. Common causes of breast and nipple dermatitis during lactation include eczema, psoriasis, mastitis,
Hamish Moore, Annabel Stevenson
wiley   +1 more source

Repurposing itraconazole for the treatment of cancer.

Oncology Letters, 2017
The repurposing of drugs is becoming increasingly attractive as it avoids the lengthy process and cost implications associated with bringing a novel drug to market. Itraconazole is a broad-spectrum anti-fungal agent. An emerging body of in vivo, in vitro
R. Pounds, Sarah M. Leonard, C. Dawson, S. Kehoe   +3 more
semanticscholar   +1 more source

Fungal‐Driven Airways Dis‐Immunity From Asthma to Allergic Bronchopulmonary Aspergillosis: Dissecting Similarities and Differences

Allergy, EarlyView.
ABSTRACT Severe asthma and allergic bronchopulmonary aspergillosis (ABPA) do not rarely coexist and share several similarities in terms of pathobiological background, together with overlapping clinical manifestations, misleading the correct diagnosis. Within that scenario, severe asthma with fungal sensitization (SAFS) further complicates the correct ...
Marco Caminati, Isabella Annesi‐Maesano, Wojciech Feleszko, Giuseppe Guida, Christer Janson, Shadi Hägg, Andrei Malinovschi, Luciana Tanno, Joana Vitte, Francesca Ambrosani, Matteo Maule   +10 more
wiley   +1 more source