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The Biological Effects of Ivabradine in Cardiovascular Disease
Molecules, 2012 A large number of studies in healthy and asymptomatic subjects, as well as patients with already established cardiovascular disease (CAD) have demonstrated that heart rate (HR) is a very important and major independent cardiovascular risk factor for ...
Sara Franceschelli +2 more
exaly +4 more sources
The effect of ivabradine on hospitalization of heart failure patients: A retrospective cohort study [PDF]
Heart Views, 2021 Background: Ivabradine is recommended in heart failure (HF) patients to reduce cardiovascular death and hospitalization due to worsening of HF symptoms.
Sara Al-Balushi +3 more
doaj +2 more sources
Early administration of ivabradine in patients admitted for acute decompensated heart failure
Frontiers in Cardiovascular Medicine, 2022 BackgroundHeart rate (HR) control is important in heart failure (HF) patients with reduced ejection fraction, and ivabradine is indicated for patients with chronic HF and sinus rhythm.
Teng-Yao Yang +7 more
doaj +1 more source
Ivabradine toxicity: a case report
Journal of Medical Case Reports, 2022 Background We describe a case of symptomatic bradycardia resulting from ivabradine toxicity by measurement of ivabradine levels, of which there are limited reports in the literature.
Kavisha Singh +6 more
doaj +1 more source
Case report: Ivabradine induced Torsades de Pointes
IHJ Cardiovascular Case Reports, 2023 Ivabradine is used to control heart rate in patients of heart failure with reduced ejection fraction. Although considered safe, it is reported to prolong QTc interval when given with other QTc prolonging drugs or in setting of hypokalemia or ...
Mohit M. Bhagwati +2 more
doaj +1 more source
ESC Heart Failure, 2022 Aims Ivabradine is indicated for heart failure (HF) patients with reduced ejection fraction (HFrEF), but limited data are available with regards to the use of ivabradine in those with a history of paroxysmal atrial fibrillation (AF). To assess the effect
Yu‐Sheng Lin +6 more
doaj +1 more source
MGM Journal of Medical Sciences, 2022 Introduction: Ivabradine is a heart rate lowering agent by inhibiting Iƒ current in sinus node. It is approved for use in patients with angina and heart failure for heart rate control.
Rohan S Thanedar +3 more
doaj +1 more source
Comparison of effects of ivabradine versus carvedilol in murine model with the Coxsackievirus B3-induced viral myocarditis. [PDF]
PLoS ONE, 2012 BACKGROUND: Elevated heart rate is associated with increased cardiovascular morbidity. The selective I(f) current inhibitor ivabradine reduces heart rate without affecting cardiac contractility, and has been shown to be cardioprotective in the failing ...
Li Yue-Chun +6 more
doaj +1 more source
The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels
Frontiers in Pharmacology, 2022 Background and purpose: Ivabradine is clinically administered to lower the heart rate, proposedly by inhibiting hyperpolarization-activated cyclic nucleotide-gated cation channels in the sinoatrial node. Recent evidence suggests that voltage-gated sodium
Benjamin Hackl +16 more
doaj +1 more source
POTENTIAL ANTIEPILEPTIC EFFECT OF IVABRADINE AGAINST PENTYLENETETRAZOLE INDUCED- KINDLEING IN MALE MICE [PDF]
Zagazig University Medical Journal, 2020 Background: Ivabradine, Hyperpolarization activated cyclic nucleotide gated (HCN) channel blocker, is the most specific blocker of central nervous system Ih current.
Heba Ahmed +2 more
doaj +1 more source