Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries [PDF]
, 2016 Blood flow generates wall shear stress (WSS) which alters endothelial cell (EC) function. Low WSS promotes vascular inflammation and atherosclerosis whereas high uniform WSS is protective. Ivabradine decreases heart rate leading to altered haemodynamics.
Ali, M. +22 more
core +2 more sources
The Biological Effects of Ivabradine in Cardiovascular Disease
Molecules, 2012 A large number of studies in healthy and asymptomatic subjects, as well as patients with already established cardiovascular disease (CAD) have demonstrated that heart rate (HR) is a very important and major independent cardiovascular risk factor for ...
Graziano Riccioni +2 more
doaj +1 more source
Effect on Mortality of Higher Versus Lower β-Blocker (Metoprolol Succinate or Carvedilol) Dose in Patients With Heart Failure [PDF]
, 2018 This study aimed to compare the effect of β-blocker dose and heart rate (HR) on mortality in patients with heart failure with reduced ejection fraction (HFrEF).
Ajam, Samer +4 more
core +1 more source
Expert consensus document: A 'diamond' approach to personalized treatment of angina. [PDF]
, 2017 In clinical guidelines, drugs for symptomatic angina are classified as being first choice (β-blockers, calcium-channel blockers, short-acting nitrates) or second choice (ivabradine, nicorandil, ranolazine, trimetazidine), with the recommendation to ...
A Abbate +101 more
core +1 more source
Identification of the molecular site of ivabradine binding to HCN4 channels.
PLoS ONE, 2013 Ivabradine is a specific heart rate-reducing agent approved as a treatment of chronic stable angina. Its mode of action involves a selective and specific block of HCN channels, the molecular components of sinoatrial "funny" (f)-channels.
Annalisa Bucchi +6 more
doaj +1 more source
Analysis of variants in the HCN4 gene and in three single nucleotide polymorphisms of the CYP3A4 gene for association with ivabradine reduction in heart rate: a preliminary report [PDF]
, 2016 [Abstract] Background: Ivabradine, a selective bradycardic drug, inhibits the If. In patients with heart failure (HF), ivabradine reduces the risk of rehospitalization and mortality.
Barge-Caballero, Eduardo +10 more
core +2 more sources
Role of ivabradine in management of stable angina in patients with different clinical profiles [PDF]
, 2018 In chronic stable angina, elevated heart rate contributes to the development of symptoms and signs of myocardial ischaemia by increasing myocardial oxygen demand and reducing diastolic perfusion time.
Camici, PG +7 more
core +2 more sources
American Heart Journal Plus, 2022 Heart rate (HR) lowering during acute coronary syndrome (ACS) is beneficial as it reduces myocardial oxygen consumption. However, the role of ivabradine as an HR-lowering agent in the setting of ACS is not clear.
Josip A. Borovac +8 more
doaj +1 more source
Pharmacist intervention in primary care to improve outcomes in patients with left ventricular systolic dysfunction [PDF]
, 2011 <b>Background</b> Meta-analysis of small trials suggests that pharmacist-led collaborative review and revision of medical treatment may improve outcomes in heart failure.<p></p> <b>Methods and results</b> We studied
Forsyth, P. +7 more
core +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio +11 more
wiley +1 more source