Results 51 to 60 of about 7,739 (166)

Inhibitory effect of sesamin on ivabradine metabolism in rats

open access: yesPakistan Journal of Pharmaceutical Sciences, 2020
In this work, the aim of our study was to assess whether sesamin could influence the pharmacokinetics of ivabradine and its active metabolite N-desmethylivabradine in rats.
Ren-ai Xu   +4 more
doaj   +1 more source

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 2151-2156, September 2026.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio   +11 more
wiley   +1 more source

Beneficial effects of ivabradine in patients with heart failure, low ejection fraction, and heart rate above 77 b.p.m.

open access: yesESC Heart Failure, 2019
Aims Ivabradine has been approved in heart failure with reduced ejection fraction (HFrEF) and elevated heart rate despite guideline‐directed medical therapy (GDMT) to reduce cardiovascular (CV) death and hospitalization for worsening HF. The median value
Nadia Bouabdallaoui   +9 more
doaj   +1 more source

Long‐Term Renal Function and Clinical Outcomes of Sacubitril/Valsartan in HFrEF and Stage 3–4 Chronic Kidney Disease: A 24‐Month Single‐Centre Cohort

open access: yesClinical Cardiology, Volume 49, Issue 9, September 2026.
In this 24‐month, single‐centre cohort of 360 patients with HFrEF and stage 3–4 chronic kidney disease, sacubitril/valsartan was well tolerated, with stable renal function, improved symptoms, and low rates of renal events and mortality. These descriptive findings are hypothesis‐generating and warrant confirmation in controlled studies.
Fatih Akkaya   +3 more
wiley   +1 more source

A possibility to interchange heart rate-slowing therapy with ivabradine and atenolol in patients with stable angina pectoris

open access: yesТерапевтический архив, 2013
AIM: To evaluate the efficiency and safety of an interchange of atenolol and ivabradine in patients who had stable angina pectoris without myocardial infarction in the history and left ventricular (LV) systolic dysfunction/MATERIAL AND METHODS: The trial
A A Shavarov   +2 more
doaj  

Management of Stable Angina with Ivabradine as Safe Alternative to Patients with Myasthenia Gravis

open access: yesCase Reports in Neurological Medicine, 2016
Management of cardiac symptoms in myasthenia gravis (MG) patients can be challenging. The aim of this report is to describe the safe use of ivabradine for stable angina in MG patients. A 48 y.o.
Giuliano Ohde Dalledone   +7 more
doaj   +1 more source

Ivabradine: Evidence and current role in cardiovascular diseases and other emerging indications

open access: yesIndian Heart Journal, 2018
Increased heart rate (HR) is associated with deleterious effects on several disease conditions. Chronic heart failure (CHF) is one of the cardiovascular diseases with recurrent hospitalization burden and an ongoing drain on health-care expenditure ...
I. Sathyamurthy, Sanket Newale
doaj   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, Volume 78, Issue 7, Page 860-874, July 2026.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

Ivabradine: beyond heart rate control.

open access: yes, 2009
Chronic stable angina pectoris (CSAP) usually occurs in patients with coronary artery disease (CAD) that affects one or more large epicardial arteries. It results when myocardial perfusion is insufficient to meet cardiac metabolic demand.
D'Orazio N., Vitulano N, Riccioni G
core   +1 more source

Strauss‐Defined LBBB Identifies Patients With Improved Outcomes After CRT‐D: A Comparative Cohort Study

open access: yesClinical Cardiology, Volume 49, Issue 7, July 2026.
In a retrospective single‐center cohort of 109 patients who underwent CRT‐D implantation, six electrocardiographic definitions of left bundle branch block (LBBB)—Strauss, Marriott, Perrin, ESC 2013, ESC 2021, and WHO/AHA—were compared for their ability to predict outcomes after cardiac resynchronization therapy (CRT).
Athanasios Saplaouras   +16 more
wiley   +1 more source

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