Results 31 to 40 of about 13,407 (237)

Baseline characteristics and treatment of patients in prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF) [PDF]

, 2014
Aim<p></p> To describe the baseline characteristics and treatment of the patients randomized in the PARADIGM-HF (Prospective comparison of ARNi with ACEi to Determine Impact on Global Mortality and morbidity in Heart Failure) trial, testing ...
Adel R. Rizkala, Akshay S Desai, Jean L. Rouleau, Jianjian Gong, John J. V. McMurray, Karl Swedberg, Martin Lefkowitz, Michael R. Zile, Milton Packer, null null, Scott D. Solomon, Victor C. Shi   +11 more
core   +3 more sources

Physiological monitoring in the complex multimorbid heart failure patient - Conclusions. [PDF]

, 2019
Comorbidities are increasingly recognized as crucial components of the heart failure syndrome. Main specific challenges are polypharmacy, poor adherence to treatments, psychological aspects, and the need of monitoring after discharge.
Böhm, M, Coats, AJS, Kindermann, I, Rosano, G, Spoletini, I   +4 more
core   +1 more source

The Role of Ivabradine in the Management of Angina Pectoris [PDF]

, 2016
Stable angina pectoris affects 2–4 % of the population in Western countries and entails an annual risk of death and nonfatal myocardial infarction of 1–2 % and 3 %, respectively.
De Silva, R, Giavarini, A
core   +2 more sources

Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

PLoS ONE, 2019
BackgroundRecently, attention has been focused on the role of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the mechanism of and as a treatment target for neuropathic and inflammatory pain.
Saki Miyake, Hitoshi Higuchi, Yuka Honda-Wakasugi, Maki Fujimoto, Hotaka Kawai, Hitoshi Nagatsuka, Shigeru Maeda, Takuya Miyawaki   +7 more
doaj   +1 more source

Ivabradin [PDF]

pharma-kritik, 2008
Mit einer neuen Wirkungsweise erreicht Ivabradin eine ähnliche antianginöse Wirkung wie Atenolol oder Amlodipin. Als Prophylaxe gegen koronare Ereignisse scheint die teure Innovation jedoch nicht wirksam.
openaire   +1 more source

Duration of chronic heart failure affects outcomes with preserved effects of heart rate reduction with ivabradine: findings from SHIFT [PDF]

, 2017
Aims: In heart failure (HF) with reduced ejection fraction and sinus rhythm, heart rate reduction with ivabradine reduces the composite incidence of cardiovascular death and HF hospitalization.
AlHabib, Boyd, Braunstein, Böhm, Böhm, Böhm, Böhm, Böhm, Böhm, Custodis, Gheorghiade, Greene, Hasenfuss, Heusch, Komajda, Lassus, Levy, Lonn, Loyaga-Rendon, Mangiacapra, Okumura, Ponikowski, Solomon, Swedberg, Tardif, Tavazzi, Tavazzi, Verbrugge, Voors   +28 more
core   +2 more sources

Ectopic Atrial Tachycardia in a 12-Month-Old Girl Treated With Ivabradine and Beta-Blocker, a Case Report

Frontiers in Pediatrics, 2020
We report on a 12-month-old girl with an ectopic atrial tachycardia successfully treated with the combination of a beta blocking agent and Ivabradine that acts on cardiac pacemaker cells by selectively inhibiting the If channel.
Holger Michel, Frank Heißenhuber, Sven Wellmann, Michael Melter, Stephan Gerling   +4 more
doaj   +1 more source

Bradycardia and atrial fibrillation in patients with stable coronary artery disease treated with ivabradine: an analysis from the SIGNIFY study [PDF]

, 2015
Aim: The aim of this study was to determine the impact of emergent bradycardia and atrial fibrillation (AF) on cardiovascular outcomes in 19 083 patients with stable coronary artery disease (CAD) receiving ivabradine or placebo (SIGNIFY, Study assessInG ...
Ferrari, Roberto, Ford, Ian, Fox, Kim, Steg, PPhilippe Gabriel, Tardif, Jean-Claude, Tendera, Michal   +5 more
core   +1 more source

Impact of Ivabradine on Inflammatory Markers in Chronic Heart Failure

Journal of Immunology Research, 2016
Background. Inflammation plays a crucial role in the progression of chronic heart failure (CHF). Ivabradine is known to reduce the morbidity and mortality of patients with CHF under certain conditions.
Ilonka Rohm, Daniel Kretzschmar, Rudin Pistulli, Marcus Franz, P. Christian Schulze, Christian Stumpf, Atilla Yilmaz   +6 more
doaj   +1 more source

Preserved Autonomic Cardiovascular Regulation With Cardiac Pacemaker Inhibition: A Crossover Trial Using High‐Fidelity Cardiovascular Phenotyping

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundSympathetic and parasympathetic influences on heart rate (HR), which are governed by baroreflex mechanisms, are integrated at the cardiac sinus node through hyperpolarization‐activated cyclic nucleotide–gated channels (HCN4).
Karsten Heusser, Jens Tank, Julia Brinkmann, Christoph Schroeder, Marcus May, Anika Großhennig, Daniela Wenzel, André Diedrich, Fred C. G. J. Sweep, Heidrun Mehling, Friedrich C. Luft, Jens Jordan   +11 more
doaj   +1 more source