Results 11 to 20 of about 5,756 (158)

Ivabradine

Reactions Weekly, 2015
Heart failure affects over 5 million people in the United States and carries a high rate of mortality. Ivabradine, a new agent has been added to the current medical options for managing heart failure. It is a selective funny current ( I f ) inhibitor in sinoatrial node and slows its firing ...
Rahul, Chaudhary, Jalaj, Garg, Parasuram, Krishnamoorthy, Neeraj, Shah, Gregg, Lanier, Mathew W, Martinez, Ronald, Freudenberger   +6 more
  +7 more sources

Observational study of new-onset atrial fibrillation in patients treated with Ivabradine alone versus Ivabradine and β-blocker drug (The BetaBrad Study)

MGM Journal of Medical Sciences, 2022
Introduction: Ivabradine is a heart rate lowering agent by inhibiting Iƒ current in sinus node. It is approved for use in patients with angina and heart failure for heart rate control.
Rohan S Thanedar, Srinivas Kudva, Prakash Sanzgiri, Charan Reddy   +3 more
doaj   +1 more source

Comparison of effects of ivabradine versus carvedilol in murine model with the Coxsackievirus B3-induced viral myocarditis. [PDF]

PLoS ONE, 2012
BACKGROUND: Elevated heart rate is associated with increased cardiovascular morbidity. The selective I(f) current inhibitor ivabradine reduces heart rate without affecting cardiac contractility, and has been shown to be cardioprotective in the failing ...
Li Yue-Chun, Zhang Teng, Zhou Na-Dan, Ge Li-Sha, Luo Qin, Guan Xue-Qiang, Lin Jia-Feng   +6 more
doaj   +1 more source

The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels

Frontiers in Pharmacology, 2022
Background and purpose: Ivabradine is clinically administered to lower the heart rate, proposedly by inhibiting hyperpolarization-activated cyclic nucleotide-gated cation channels in the sinoatrial node. Recent evidence suggests that voltage-gated sodium
Benjamin Hackl, Peter Lukacs, Janine Ebner, Krisztina Pesti, Krisztina Pesti, Nicholas Haechl, Mátyás C Földi, Mátyás C Földi, Elena Lilliu, Klaus Schicker, Helmut Kubista, Anna Stary-Weinzinger, Karlheinz Hilber, Arpad Mike, Arpad Mike, Hannes Todt, Xaver Koenig   +16 more
doaj   +1 more source

POTENTIAL ANTIEPILEPTIC EFFECT OF IVABRADINE AGAINST PENTYLENETETRAZOLE INDUCED- KINDLEING IN MALE MICE [PDF]

Zagazig University Medical Journal, 2020
Background: Ivabradine, Hyperpolarization activated cyclic nucleotide gated (HCN) channel blocker, is the most specific blocker of central nervous system Ih current.
Heba Ahmed, elsayed kamel, ahmed abdelsamee   +2 more
doaj   +1 more source

Ivabradine

Reactions Weekly
Reed M, Patel P.
europepmc   +5 more sources

Effects of selective heart rate reduction with ivabradine on LV function and central hemodynamics in patients with chronic coronary syndrome

International Journal of Cardiology: Heart & Vasculature, 2021
Objectives: We assessed left ventricular (LV) function and central hemodynamic effects in patients with a heart rate (HR) at rest of ≥70 beats per minute (bpm) and chronic coronary syndrome (CCS) after long-term treatment with ivabradine compared to ...
Anna Lena Hohneck, Peter Fries, Jonas Stroeder, Günther Schneider, Stephan Henrik Schirmer, Jan-Christian Reil, Michael Böhm, Ulrich Laufs, Florian Custodis   +8 more
doaj   +1 more source

Combination of ivabradine and sacubitril/valsartan in patients with heart failure and reduced ejection fraction

ESC Heart Failure, 2021
Aims Ivabradine and sacubitril/valsartan are second‐line therapies for patients with heart failure and reduced ejection fraction (HFrEF) based on guideline recommendations. We aimed to evaluate the synergistic effects of these two medications.
Ying‐Hsiang Lee, Po‐Lin Lin, Wei‐Ru Chiou, Jin‐Long Huang, Wen‐Yu Lin, Chia‐Te Liao, Fa‐Po Chung, Huai‐Wen Liang, Chien‐Yi Hsu, Hung‐Yu Chang   +9 more
doaj   +1 more source

The isolated working guinea pig heart: A functional and electrophysiological characterisation. [PDF]

Exp Physiol
Abstract Small animal isolated perfused hearts have been used for over 150 years for the study of cardiac physiology and pharmacology. The guinea pig heart represents the smallest mammalian heart that replicates key features of the human heart – for example, with respect to cardiac action potential duration, ion channel expression, excitation ...
Anderson-Barker GC, Shattock MJ.
europepmc   +2 more sources

Efficacy and Safety of Ivabradine Once-Daily Prolonged-Release versus Twice-Daily Immediate-Release Formulation in Patients with Stable Chronic Heart Failure with Systolic Dysfunction: A Randomized, Double-Blind, Phase 3 Non-Inferiority (PROFICIENT) Study

Cardiology and Therapy, 2020
Introduction Dosing frequency is an important factor influencing medication compliance in patients with heart failure (HF), which in turn is imperative in achieving the desired therapeutic outcome.
Ajit Mullasari, The PROFICIENT investigators   +1 more
doaj   +1 more source