Results 221 to 230 of about 94,897 (251)
Activation of Myeloid Dendritic Cells by Up-Regulating RAGE/JAK/STAT Pathway Induced by Cigarette Smoke Exposure in Mice With Emphysema. [PDF]
Mediators InflammGao J +5 more
europepmc +1 more source
YTHDF2 promotes the metastasis of oral squamous cell carcinoma through the JAK-STAT pathway. [PDF]
Sci RepChen Z +8 more
europepmc +1 more source
The JAK-STAT Signaling Pathway in Epilepsy
Current Neuropharmacology, 2023 Abstract: Epilepsy is defined as spontaneous recurrent seizures in the brain. There is increasing evidence that inflammatory mediators and immune cells are involved in epileptic seizures. As more research is done on inflammatory factors and immune cells in epilepsy, new targets for the treatment of epilepsy will be revealed.
Jia-Ai Li, Di Ma, Hongmei Meng
exaly +3 more sources
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Molecular Immunology, 2000
A variety of important cellular functions are regulated by cytokines. The Jak-STAT pathway is one of the important signaling pathways downstream of cytokine receptors. Following binding of a ligand to its cognate receptor, receptor-associated Jaks are activated.
K, Imada, W J, Leonard
openaire +2 more sources
A variety of important cellular functions are regulated by cytokines. The Jak-STAT pathway is one of the important signaling pathways downstream of cytokine receptors. Following binding of a ligand to its cognate receptor, receptor-associated Jaks are activated.
K, Imada, W J, Leonard
openaire +2 more sources
The JAK-STAT pathway in Drosophila
Trends in Genetics, 1997Recent studies in Drosophila have identified a single JAK and a single STAT protein. Genetic and biochemical analyses reveal that these two proteins operate in the same signal transduction pathway. Phenotypic analyses of JAK and STAT mutants implicate this pathway in a number of developmental decisions, in particular the regulation of pair-rule genes ...
X S, Hou, N, Perrimon
openaire +2 more sources
Science Signaling, 2003
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to transcription factors that bind target gene promoters in the nucleus.
David S. Aaronson, Curt M. Horvath
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The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to transcription factors that bind target gene promoters in the nucleus.
David S. Aaronson, Curt M. Horvath
openaire +1 more source
Jak/Stat Pathway in Waldenström's Macroglobulinemia
Clinical Lymphoma Myeloma and Leukemia, 2011While high serum concentrations of immunoglobulin M (IgM) protein are responsible for much of the morbidity associated with Waldenström's macroglobulinemia (WM), the mechanisms controlling IgM secretion in this malignancy remain unknown. The Jak/Stat signaling pathway mediates the effects of most cytokines involved in stimulating immunoglobulin ...
Lucy S, Hodge, Stephen M, Ansell
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Negative regulation of the JAK/STAT pathway
BioEssays, 1999Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways, such as the JAK/STAT pathway. Although these responses are generally transient, few molecules have been characterised that switch the signal off.
R, Starr, D J, Hilton
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Role of the JAK–STAT pathway in myocardial injury
Trends in Molecular Medicine, 2007Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of research; the molecular mechanisms and pathways that control the underlying pathologies are still not fully appreciated. The Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway has recently been shown to be an integral part ...
Barry, Seán P. +3 more
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