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The JAK/STAT pathway and Drosophila development
BioEssays, 2001AbstractThe JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila. Mutational analyses of these components have revealed a number of interesting developmental roles, and provide a mechanism
H, Luo, C R, Dearolf
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Reactome - a curated knowledgebase of biological pathways, 2006
N Perrimon, MG Williams
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N Perrimon, MG Williams
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The Jak-STAT Pathway Stimulated by Interferon γ
Science's STKE, 2004Different cytokines stimulate the Janus kinase (Jak) and signal transducer and activator of transcription (STAT) pathway. Interferon γ (IFN-γ) is a type II interferon that triggers antiviral and adaptive immune responses through a Jak-STAT signaling pathway.
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The Jak-STAT Pathway Stimulated by Interleukin 6
Science's STKE, 2004Signal transducer and activator of transcription 3 (STAT3) is widely expressed and activated by a variety of growth-regulating signals as well as diverse cytokines that use gp130 signaling receptors. STAT3 is critical for embryonic development and stem cell biology, as well as inflammation, growth regulation, and multiple immune regulatory and ...
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Inactivation of the JAK-STAT Pathway
1998Signaling pathways involving Janus kinases (JAKs) and Signal Transducers and Activators of Transcription (STATs) play an important role in cytokine-induced gene transcription. Aberrant stimulation of this pathway can lead to abnormal development and cellular transformation demonstrating the importance of understanding mechanisms of downregulation ...
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The role of JAK/STAT signaling pathway and its inhibitors in diseases
International Immunopharmacology, 2020Shuang Liu, Youzhi Wang
exaly

