Results 141 to 150 of about 73,607 (303)

Jak2 46/1 Haplotype Is Associated With Jak2 V617f--positive Myeloproliferative Neoplasms In Brazilian Patients.

, 2016
This study aimed to verify the association between the JAK2 46/1 haplotype (V617F positive) and some hematological parameters in BCR-ABL-negative chronic myeloproliferative neoplasms (cMPNs) in our population. The blood samples obtained from the patients
L. C.; Santos, K. B. B.; Rodrigues, Ambrosio-Albuquerque, E P, Sell, A M, Pagliarini-e-Silva, S, Macedo, F. C.; Ferreira, E. C.; Ambrosio-Albuquerque, Visentainer, J E L, Santos, B C, J. E. L., S.; Pagnano, A. M.; Visentainer, Ferreira, M E, E. P.; Sell, Rodrigues, C, Quintero, F C, Macedo, L C, M. E.; Baraldi, Baraldi, E C, C.; Quintero, B. C.; Pagliarini-E-Silva, Pagnano, K B B   +22 more
core   +1 more source

JAK Inhibitors in Psoriatic–Atopic Dermatitis Overlap: A Four‑Case Series

JEADV Clinical Practice, EarlyView.
ABSTRACT Overlap between psoriasis and atopic dermatitis (AD) poses diagnostic and therapeutic challenges; monoclonal antibodies targeting a single axis may improve one component while worsening the other [1]. Janus kinase (JAK) inhibitors act pleiotropically and may provide simultaneous control of psoriatic and eczematous inflammation [2].
Eleonora Bongiovanni, Francois Rosset, Isotta Giunipero di Corteranzo, Lorenzo Bellando, Rebecca Senetta, Simone Ribero, Pietro Quaglino   +6 more
wiley   +1 more source

Vaccarin Improves Myocardial Ischemia–Reperfusion Injury by Attenuating Oxidative Stress and Ferroptosis Through Reducing NOX4‐Modulated JAK2/STAT3 Pathway Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Vaccarin is a naturally occurring flavonoid glycoside with cardioprotective properties; however, its involvement in myocardial ischemia–reperfusion (MI/R) injury remains poorly defined. We herein investigated whether vaccarin protects cardiomyocytes from MI/R‐induced dysfunction in vivo and in vitro and examined the associated molecular ...
Han Yang, Mi Zhou, Feng‐Cai Zhang
wiley   +1 more source

The Molecular Heterogeneity of NRAS Variants in Thyroid Nodules

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective NRAS variants are the most common mutations in thyroid nodules with (B)ethesda III/IV cytology. This study aims to characterize co‐occurring variants, molecular signatures, and hallmarks of cancer pathways in nodules with NRAS variants. Study Design Retrospective database analysis.
Emma De Ravin, Mohammed Alshalalfa, Ruochen Jiang, Yangyang Hao, Joshua P. Klopper, Elizabeth Cottrill   +5 more
wiley   +1 more source

Assessing relational values of sacred landscapes through text mining of folktales: Insights from the Ryukyu Islands, Japan

People and Nature, EarlyView.
Abstract Assessing relational values of nature through its cultural and spiritual significance is crucial for effective nature conservation. Folktales offer insights into traditional relationships between people and nature, and text mining is a powerful tool for extracting information from textual datasets.
Naoki Saito, Soyo Takahashi, Akira Iguchi   +2 more
wiley   +1 more source

Identification of Tubulin as a Substrate of Jak2 Tyrosine Kinase and Its Role in Jak2-Dependent Signaling^†

, 2016
Jak2 is a nonreceptor tyrosine kinase that acts in numerous cellular signal transduction systems. Here, large amounts of recombinant Jak2 protein were expressed in eukaryotic cells, and an unknown 55 kDa protein was copurified with it.
Peter P. Sayeski (395099), Xianyue Ma (2487904)   +1 more
core   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment

, 2017
OBJECTIVES: Janus kinase 2 (JAK2) has recently been described as a novel downstream mediator of the pro-fibrotic effects of transforming growth factor-β.
Schett, Georg, Jörg H W Distler, Distler, Alfiya, Dirk Mielenz, Georg Schett, Ruifang Liang, Liang, Ruifang, Tatjana Mallano, Mallano, Tatjana, Alfiya Distler, Kolja Gelse, Reich, Adam, Adam Reich, Distler, Oliver, Mielenz, Dirk, Zhang, Yun, Chih-Wei Chen, Clara Dees, Dees, Clara, Chen, Chih-Wei, Bergmann, Christina, Ramming, Andreas, Andreas Ramming, Gelse, Kolja, Distler, Jörg H W, Christina Bergmann, Oliver Distler, Yun Zhang   +27 more
core   +1 more source

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source