Results 141 to 150 of about 79,208 (292)
JAK2 inactivating mutations promotes endometrial cancer progression by targeting HIF-1α
Discover OncologyObjective Endometrial cancer (EC) is the ninth most common malignancy among women. While mutations in JAK2 are frequently observed in EC, the specific biological functions of JAK2 in endometrial cancer are poorly understood.
Zheng Chen +4 more
doaj +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.TGF‐β1 increases DNMT1?mediated SOCS3 promoter hypermethylation to repress SOCS3 expression. Loss of SOCS3‐dependent inhibition de‐represses JAK2‐STAT3 signaling and drives abnormal activation of vocal fold fibroblasts, contributing to vocal fold fibrosis. ABSTRACT Objective To investigate the effect of TGF‐β1 on vocal fold fibroblasts (VFFs) phenotype
Hai‐Zhou Wang +4 more
wiley +1 more source
Systemic Treatment of Psoriasis: Current Evidence on Efficacy and Safety
The Journal of Dermatology, EarlyView.ABSTRACT Systemic treatments for moderate‐to‐severe plaque psoriasis have been advanced from broad immunosuppressants up to agents more selectively targeting cytokines, cytokine receptors, or intracellular signaling. The current systemic treatments mainly consist of conventional systemic agents, biologics targeting tumor necrosis factor (TNF)‐α ...
Teppei Hagino, Naoko Kanda
wiley +1 more source
Allergy, EarlyView.Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri +11 more
wiley +1 more source
Ratio of Mutant JAK2-V617F to Wild Type Jak2 Determines the MPD Phenotypes in Transgenic Mice.
The reason why the JAK2-V617F mutation is associated with several phenotypic manifestations of human myeloproliferative disorders (MPD), i.e. polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF), is currently unknown. We
Sobas, Marta A. +6 more
core +1 more source
Andrology, EarlyView.ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick +7 more
wiley +1 more source
ANZ Journal of Surgery, EarlyView.Splenectomy is a safe and effective treatment option in selected patients with haematological disease, despite declining referrals over the last 27 years in the era of targeted therapies. Outcomes are favourable when performed laparoscopically and long‐term follow‐up demonstrates sustained haematologic benefit in surviving patients.
Salil Dutt Barrett +9 more
wiley +1 more source
, 2016 [[abstract]]Background: The nasopharyngeal carcinoma (NPC) has distinct incidence in various races and different geographical regions. It is endemic in southern China, Southeast Asia, and the Middle East.
Liang, PI;Li, CF
core
British Journal of Haematology, EarlyView.Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo +3 more
wiley +1 more source
Survival outcomes and treatment patterns in myelofibrosis in the JAK inhibitor era
British Journal of Haematology, EarlyView.Summary Data on real‐world survival and treatment patterns in large, unselected myelofibrosis (MF) cohorts remain limited. We analysed 1649 patients with MF diagnosed from 2010 onwards and included in the Spanish Myelofibrosis Registry across 64 centres. Janus kinase (JAK) inhibitors were administered to approximately half of the patients.
Juan‐Carlos Hernández‐Boluda +35 more
wiley +1 more source