Results 121 to 130 of about 73,607 (303)

t(8;9)(p22;p24)/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5.

PLoS ONE, 2013
Fusions of the tyrosine kinase domain of JAK2 with multiple partners occur in leukemia/lymphoma where they reportedly promote JAK2-oligomerization and autonomous signalling, Affected entities are promising candidates for therapy with JAK2 signalling ...
Stefan Ehrentraut, Stefan Nagel, Michaela E Scherr, Björn Schneider, Hilmar Quentmeier, Robert Geffers, Maren Kaufmann, Corinna Meyer, Monika Prochorec-Sobieszek, Rhett P Ketterling, Ryan A Knudson, Andrew L Feldman, Marshall E Kadin, Hans G Drexler, Roderick A F MacLeod   +14 more
doaj   +1 more source

Iron deficiency in JAK2 exon12 and JAK2-V617F mutated polycythemia vera [PDF]

Blood Cancer Journal, 2021
Dan Liu, Zefeng Xu, Peihong Zhang, Tiejun Qin, Bing Li, Shiqiang Qu, Lijuan Pan, Wenyu Cai, Jinqin Liu, Huijun Wang, Qi Sun, Xiujuan Sun, Meng Jiao, Qingyan Gao, Zhongxun Shi, Huijun Huang, Gang Huang, Robert Peter Gale, Zhijian Xiao   +18 more
openaire   +3 more sources

JAK 2-Positive Diseases and Spontaneous Coronary Artery Dissection: Case Series

Case Reports in Oncology
Introduction: Chronic myeloproliferative neoplasms (MPNs) such as polycythaemia vera (PV) and essential thrombocytosis are associated with atherosclerosis and cardiovascular events, especially if JAK2 mutation is there.
Ahmed K.A. Yasin, Shehab Fareed Mohamed, Elmustafa Abdalla, Girish Rao, Abdulaziz M. Alkhulaifi, Mohamed A. Yassin, Deena Mudawi, Abdulrahman Fadhl Al-Mashdali, Samah Kohla, Feryal A. Ibrahim, Dina Soliman, Cornelia S. Carr   +11 more
doaj   +1 more source

Jak2 inhibits GHR endocytosis.

, 2013
A. GHR-expressing Hek293 cells were transfected with empty vector (EV), Flag-Jak2, Flag-Jak2(Y119E) or Flag-Jak2(1-525). One coverslip was incubated for 15 min with Cy3-GH at 37°C, fixed and stained with anti-Flag (left panels).
Peter van Kerkhof (356257), Ana Gracanin (356259), Joyce Putters (356255), Ana C. da Silva Almeida (356256), Ger J. Strous (299053), Agnes G. S. H. van Rossum (356258)   +5 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

The genetic and symptomatic link of polycythemia vera. narrative review

Revista Mexicana de Investigación Médica
Myeloproliferative neoplasms (MPNs), such as essential thrombocythemia (ET), primary myelofibrosis (PMF), and polycythemia vera (PV), are clonal hematologic disorders.
Asheley Jezabel Flores Hernández, Alondra Elizabeth Pérez Tlapa, Felix Santos González, Yessica Ibelith Cosme Herrera   +3 more
doaj   +1 more source

Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre‐cancer lesions

International Journal of Cancer, EarlyView.
What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin, Venugopalareddy Mekala, Jianrong Li, Xiang Wang, Muhammad Aminu, Jia Wu, Jianjun Zhang, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng   +9 more
wiley   +1 more source

The effect of exogenous in vitro expression of wild type and mutant JAK2 in erythroblast progenitors [PDF]

Red blood cell (RBC) transfusion has become a routine and indispensable procedure for many clinical purposes. As there is no appropriate alternative, the in vitro manufacture of RBCs is a potential means to ensure an adequate and safe supply of blood ...
Aquilina, Sephora
core  

Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements

Haematologica, 2013
JAK2 fusion genes are rare but recurrent abnormalities associated with diverse, clinically heterogeneous hematologic malignancies. Here we assess the JAK1/2 inhibitor ruxolitinib as therapy for patients with JAK2-rearrangement associated ...
Andrew Chase, Catherine Bryant, Joannah Score, Claudia Haferlach, Vera Grossmann, Juliana Schwaab, Wolf-Karsten Hofmann, Andreas Reiter, Nicholas C.P. Cross   +8 more
doaj   +1 more source

α2,3‐Sialyltransferase (ST3Gal1) regulates endometrioid‐type epithelial ovarian cancer cell migration and invasion via VEGF‐R2/JAK2/STAT3 signaling cascades

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao, Chia‐Hao Liu, Szu‐Ting Yang, Chen‐Hao Lin, Liang‐Wei Wang, Peng‐Hui Wang   +5 more
wiley   +1 more source