Results 101 to 110 of about 73,607 (303)

CALRETICULIN IN MYELOPROLIFERATIVE NEOPLASMS: THE OTHER SIDE OF THE ALICE MIRROR [PDF]

European Medical Journal Hematology, 2014
Calreticulin (CALR), a Ca2+ binding protein mostly localised in the endoplasmic reticulum, regulates Ca2+ homeostasis, chaperones, and other proteins to the nucleus and other cellular compartments.
Lilian Varricchio, Anna Rita Migliaccio
doaj  

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma

, 2011
The genetics of classical Hodgkin lymphoma (cHL) is poorly understood. The finding of a JAK2-involving t(4;9)(q21;p24) in 1 case of cHL prompted us to characterize this translocation on a molecular level and to determine the prevalence of JAK2 ...
Chris De Wolf-Peeters, Idoya Lahortiga, Jan Cools, Iwona Wlodarska, Olga Gielen, Gregor Verhoef, Peter Marynen, Luk Cox, Barbara Cauwelier, Katrien Van Roosbroeck, Thomas Tousseyn, Pascale De Paepe, Peter Vandenberghe   +12 more
core   +1 more source

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms [PDF]

, 2015
Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,
Pieri, L., Döhner, Konstanze, Reiter, A., Evans, Paul, Giannopoulos, Andreas, Cross N.C., Harutyunyan, Ashot S., Stegelmann, F., Cross, N.C.P., White, Helen E, Leung, William, Ewing, Joanne, Chen, E., Nangalia, Jyoti, Mannarelli, Carmela, Tapper, W., Harrison, C.N., Chase, A.J., Tanaka, T., Jones, A.V., Mead, Adam J, Short, M., Gisslinger, Heinz, Waghorn, Katherine, Jack, A., Cazzola, M., Griffiths, M., Cross, Nicholas C. P., Callaway, Alison, Ward, Daniel, Mead, A.J., Vannucchi, A.M., Baxter, E.J., Cross, Nicholas C.P., Harutyunyan, Ashot S, Zoi, K., Guglielmelli, Paola, Grallert, H., Ewing, J., Bandinelli, S., Oscier, D., Joanna Baxter, E., Cross, Nicholas C P, Lin, Feng, Kralovics, R., Chase, Andrew, Godfrey, A.L., Baxter, E. Joanna, Campbell, Peter, Kralovics, Robert, Short, Michael, Callaway, A., Aranaz, P., Waghorn, K., Gale, Rosemary E., Barosi, G., Duncombe, Andrew S, Chen, Edwin, Baxter, E Joanna, Campbell, P.J., White, Helen E., Nangalia, J., Duncombe, A.S., Duncombe, Andrew S., Stegelmann, Frank, Jones, Amy V, Haferlach, Torsten, Giannopoulos, A., Ward, D., Vannucchi, Alessandro, Tanaka, Toshiko, Maclean, Cathy, Mead, Adam J., Grallert, Harald, Lin, F., Barosi, Giovanni, Jack, Andrew, Mannarelli, C., Campbell P., Gisslinger, H., Vannucchi, A., Schnittger, S., Leung, W., Aranaz, Paula, Godfrey, Anna L., Schuh, Anna, Harutyunyan, A.S., Green, Anthony R., Harrison, C., Vannucchi, Alessandro Maria, Oscier, David, Zoi, Katerina, Pieri, Lisa, Maclean, C., Griffiths, Michael, Schuh, A., Strauch, K., Tapper, William, Chase, A., Evans, P., Guglielmelli, P., Gale, R.E., Schnittger, Susanne, White, H.E., Wallis, Louise, Green, A.R., Reiter, Andreas, Gale, Rosemary E, Bandinelli, Stefania, Godfrey, Anna L, Cazzola, Mario, Wallis, L., Harrison, Claire, Baxter, E., Jones, Amy V., Haferlach, T., Strauch, Konstantin, Döhner, K., Green, Anthony R   +118 more
core   +1 more source

Associations of CYLD, JAK2 and TLR4 Genotypes with PSA Levels and Immunophenotype in Benign Prostatic Hyperplasia and Prostate Cancer

Frontiers in Bioscience-Landmark
Background: Prostate cancer (PCa) is one of the most common malignant tumors of the male urinary system, and its incidence and mortality rates have been increasing worldwide.
Le Vu Duy, Pham Thi Huong, Nguyen Trung Nam, Do Thi Trang, Nghiem Thi Minh Chau, Tran Thi Phuong Thao, Nguyen Huy Hoang, Nguyen Thien Tao, Can Van Mao, Nguyen Thi Xuan   +9 more
doaj   +1 more source

Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models

Arthritis &Rheumatology, EarlyView.
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Elizabeth Bagley, Joanna Parkes, Xinyu Jia, Nandhana Sudhan, Alfredo Guzman, Kanneboyina Nagaraju, Melissa Morales   +11 more
wiley   +1 more source

Importância da investigação da mutação JAK2V617F em pacientes com neoplasia mieloproliferativa crônica BCR/ABL negativa e sua associação com a expressão da proteína antiapoptótica survivina como marcador diagnóstico [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2011As neoplasias mieloproliferativas crônicas (NMPC) são neoplasias originadas por uma proliferação ...
Barcelos, Michelle Maccarini
core  

Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders

, 2008
Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) associated with somatic mutations of JAK2 and, in few instances, of LNK and characterized by increased red blood cell production.
Skoda R, Brisci A, Pietra D, Gisslinger H, Cremonesi L, Cazzola M., PASSAMONTI, FRANCESCO, Ferrari M, RUMI, ELISA, CAZZOLA, MARIO, Li S, Theocharides A, Rumi E, Kralovics R   +13 more
core   +2 more sources

Beyond Ruxolitinib: Fedratinib and Other Emergent Treatment Options for Myelofibrosis

Cancer Management and Research, 2019
Jan Philipp Bewersdorf,1 Sara Mohamed Jaszczur,2 Salma Afifi,2 Jennifer C Zhao,2 Amer M Zeidan1,3 1Department of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; 2Department of Pharmacy, Yale New Haven Hospital, New ...
Bewersdorf JP, Jaszczur SM, Afifi S, Zhao JC, Zeidan AM   +4 more
doaj  

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source