Results 101 to 110 of about 79,208 (292)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

t(8;9)(p22;p24)/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5.

PLoS ONE, 2013
Fusions of the tyrosine kinase domain of JAK2 with multiple partners occur in leukemia/lymphoma where they reportedly promote JAK2-oligomerization and autonomous signalling, Affected entities are promising candidates for therapy with JAK2 signalling ...
Stefan Ehrentraut, Stefan Nagel, Michaela E Scherr, Björn Schneider, Hilmar Quentmeier, Robert Geffers, Maren Kaufmann, Corinna Meyer, Monika Prochorec-Sobieszek, Rhett P Ketterling, Ryan A Knudson, Andrew L Feldman, Marshall E Kadin, Hans G Drexler, Roderick A F MacLeod   +14 more
doaj   +1 more source

JAK 2-Positive Diseases and Spontaneous Coronary Artery Dissection: Case Series

Case Reports in Oncology
Introduction: Chronic myeloproliferative neoplasms (MPNs) such as polycythaemia vera (PV) and essential thrombocytosis are associated with atherosclerosis and cardiovascular events, especially if JAK2 mutation is there.
Ahmed K.A. Yasin, Shehab Fareed Mohamed, Elmustafa Abdalla, Girish Rao, Abdulaziz M. Alkhulaifi, Mohamed A. Yassin, Deena Mudawi, Abdulrahman Fadhl Al-Mashdali, Samah Kohla, Feryal A. Ibrahim, Dina Soliman, Cornelia S. Carr   +11 more
doaj   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Truncated JAK2 protein resulting from JAK2 Δexon14 mutation in patients with chronic myeloproliferative neoplasms.

, 2013
Lysates were prepared from the indicated human CML K562 cell line (Lane1), a patient with chronic myelogenous leukemia (lane 2), and 5 patients with chronic MPNs (Lanes 3–7).
Xiuqiang Wang (362502), Xi Zhang (83736), Jean Marie Bruey (362503), Hagop Kantarjian (210144), Chen-Hsiung Yeh (345946), Zhong Zhang (103242), Francis Giles (345947), Maher Albitar (345948), Wanlong Ma (345945), Susan O'Brien (17079)   +9 more
core   +1 more source

Protective Role of Polydatin Against Vancomycin‐Induced Lung Toxicity via Oxidative Stress, Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Ferroptosis Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate whether polydatin (Poly) could eliminate the harmful effects of vancomycin (VCM) on the lungs of rats. Rats were administered VCM (200 mg/kg) and Poly (50 mg/kg), both separately and in combination, for a duration of 7 days.
Serpil Aygörmez, Sefa Küçükler, Selim Çomaklı, Hasan Şimşek, Özge Kandemir, Fatih Mehmet Kandemir, Şaban Maraşlı   +6 more
wiley   +1 more source

Lymphotoxin-beta receptor and RANK signaling in TEL-JAK2-induced T-cell leukemia [PDF]

, 2015
Tese de doutoramento, Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, 2015T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy that arises from the combination of genetic and
Fernandes, Mónica Alexandra Teotónio
core  

Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders

, 2008
Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) associated with somatic mutations of JAK2 and, in few instances, of LNK and characterized by increased red blood cell production.
Skoda R, Brisci A, Pietra D, Gisslinger H, Cremonesi L, Cazzola M., PASSAMONTI, FRANCESCO, Ferrari M, RUMI, ELISA, CAZZOLA, MARIO, Li S, Theocharides A, Rumi E, Kralovics R   +13 more
core   +2 more sources

The genetic and symptomatic link of polycythemia vera. narrative review

Revista Mexicana de Investigación Médica
Myeloproliferative neoplasms (MPNs), such as essential thrombocythemia (ET), primary myelofibrosis (PMF), and polycythemia vera (PV), are clonal hematologic disorders.
Asheley Jezabel Flores Hernández, Alondra Elizabeth Pérez Tlapa, Felix Santos González, Yessica Ibelith Cosme Herrera   +3 more
doaj   +1 more source