Results 91 to 100 of about 73,607 (303)

Effect of Rhodomyrtus tomentosa (Aiton) Hassk. on aortic hyperglycemia via JAK family expression [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Hyperglycemia is a significant contributor to the development of atherosclerosis and is a major risk factor. The process initiates with the phosphorylation of JAK1 and JAK2, subsequently leading to the activation of STAT3, which results in ...
Putri Cahaya Situmorang, Rony Abdi Syahputra, Etti Sartina Siregar, Mimmy Sari Syah Putri, Trina Ekawati Tallei, Eka Setiawan   +5 more
doaj   +1 more source

Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2 V617F-induced myeloproliferative neoplasms

Blood Cancer Journal, 2022
Janus kinase 2 (JAK2) hyperactivation by JAK2 V617F mutation leads to myeloproliferative neoplasms (MPNs) and targeting JAK2 could serve as a promising therapeutic strategy for MPNs.
Mengshi Hu, Tao Yang, Linyu Yang, Lu Niu, Jinbing Zhu, Ailin Zhao, Mingsong Shi, Xue Yuan, Minghai Tang, Jianhong Yang, Heying Pei, Zhuang Yang, Qiang Chen, Haoyu Ye, Ting Niu, Lijuan Chen   +15 more
doaj   +1 more source

Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling

Science Advances
Janus kinase 2 (JAK2) mediates type I/II cytokine receptor signaling, but JAK2 is also activated by somatic mutations that cause hematological malignancies by mechanisms that are still incompletely understood. Quantitative superresolution microscopy (qSMLM) showed that erythropoietin receptor (EpoR) exists as monomers and dimerizes upon Epo stimulation
Bobin George Abraham, Teemu Haikarainen, Joni Vuorio, Mykhailo Girych, Anniina T. Virtanen, Antti Kurttila, Christos Karathanasis, Mike Heilemann, Vivek Sharma, Ilpo Vattulainen, Olli Silvennoinen   +10 more
openaire   +5 more sources

Tyrosine 813 Is a Site of JAK2 Autophosphorylation Critical for Activation of JAK2 by SH2-Bβ [PDF]

Molecular and Cellular Biology, 2004
The tyrosine kinase Janus kinase 2 (JAK2) binds to the majority of the known members of the cytokine family of receptors. Ligand-receptor binding leads to activation of the associated JAK2 molecules, resulting in rapid autophosphorylation of multiple tyrosines within JAK2.
Jason H, Kurzer, Lawrence S, Argetsinger, Yong-Jie, Zhou, Jean-Louis K, Kouadio, John J, O'Shea, Christin, Carter-Su   +5 more
openaire   +2 more sources

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

A Type II JAK2 Inhibitor Is Active in JAK2-Dependent Malignancies [PDF]

Cancer Discovery, 2015
Abstract CHZ868 inhibits the proliferation of JAK2-mutant and type I JAK inhibitor–persistent cells.
openaire   +1 more source

“Intrapericardial Approach” for Venous Outflow Reconstruction in Living‐Donor Liver Transplantation for Budd‐Chiari Syndrome: Surgical Techniques and LongTerm Outcomes

Annals of Gastroenterological Surgery, EarlyView.
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata, Tetsuya Tajima, Satoshi Ogiso, Shinji Uemoto, Etsuro Hatano   +4 more
wiley   +1 more source

Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis.

, 2014
JAK inhibitor treatment is limited by the variable development of anemia and thrombocytopenia thought to be due to on-target JAK2 inhibition. We evaluated the impact of Jak2 deletion in platelets (PLTs) and megakaryocytes (MKs) on blood counts, stem ...
Kleppe, Maria, Levine, Ross L, Woods, Brittany A, Meyer, Sara C, LaFave, Lindsay M, Marubayashi, Sachie, Bhagwat, Neha, Keller, Matthew D, Bastian, Lennart   +8 more
core   +1 more source

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

Truncated JAK2 protein resulting from JAK2 Δexon14 mutation in patients with chronic myeloproliferative neoplasms.

, 2013
Lysates were prepared from the indicated human CML K562 cell line (Lane1), a patient with chronic myelogenous leukemia (lane 2), and 5 patients with chronic MPNs (Lanes 3–7).
Xiuqiang Wang (362502), Xi Zhang (83736), Jean Marie Bruey (362503), Hagop Kantarjian (210144), Chen-Hsiung Yeh (345946), Zhong Zhang (103242), Francis Giles (345947), Maher Albitar (345948), Wanlong Ma (345945), Susan O'Brien (17079)   +9 more
core   +1 more source