Results 81 to 90 of about 73,607 (303)

JAK2-tree:a simple CBC-based decision rule to guide appropriate JAK2 V617F mutation testing [PDF]

, 2019
AIMS: The JAK2 V617F mutation is highly recurrent in many of the myeloproliferative neoplasms, a molecular variant that can be easily detected using sensitive and minimally invasive techniques.
Lynch, Tarah, Bojesen, Stig Egil, Pedersen, Kasper Mønsted, Khan, Faisal, Shabani-Rad, Meer-Taher, Çolak, Yunus, Mahe, Etienne, Sinclair, Gary   +7 more
core   +1 more source

Curcumin induces apoptosis in JAK2‐mutated cells by the inhibition of JAK2/STAT and mTORC1 pathways [PDF]

Journal of Cellular and Molecular Medicine, 2019
AbstractMyeloproliferative neoplasms are chronic myeloid cancers divided in Philadelphia positive and negative. The JAK2 V617F is the most common mutation in Philadelphia negative patients and results in a constitutive activation of the JAK/STAT pathway, conferring a proliferative advantage and apoptosis inhibition.
Jessica Petiti, Valentina Rosso, Marco Lo Iacono, Cristina Panuzzo, Chiara Calabrese, Elisabetta Signorino, Lucrezia Pironi, Antonio Cartellà, Enrico Bracco, Barbara Pergolizzi, Tiziana Beltramo, Carmen Fava, Daniela Cilloni   +12 more
openaire   +2 more sources

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Britannin suppresses MCF-7 breast cancer cell growth by inducing apoptosis and inhibiting autophagy [PDF]

Avicenna Journal of Phytomedicine
Objective: Breast cancer is the main reason for cancer-related death in women. Britannin is a sesquiterpene lactone compound derived from Inula aucheriana with anti-tumor properties. We aimed to explore the impacts of britannin on apoptosis and autophagy
Sadegh Rajabi, Mahboubeh Irani, Marzieh Moeinifard, Maryam Hamzeloo-Moghadam   +3 more
doaj   +1 more source

JAK2 inhibitor persistence in MPN: uncovering a central role of ERK activation

Blood Cancer Journal, 2022
The Philadelphia chromosome negative myeloproliferative neoplasms, including polycythemia vera, essential thrombocytosis, and myelofibrosis, are driven by hyper activation of the JAK2 tyrosine kinase, the result of mutations in three MPN driving genes ...
Garima Pandey, Andrew T. Kuykendall, Gary W. Reuther   +2 more
doaj   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm

, 2010
Acute myeloid leukemia (AML) may follow a JAK2-positive myeloproliferative neoplasm (MPN), although the mechanisms of disease evolution, often involving loss of mutant JAK2, remain obscure.
Chen, Edwin, Kusec, Rajko, McMullin, Mary Frances, Harrison, Claire N, Beer, P.A., Vainchenker, W., Delhommeau, François, Lecouedic, J.P., Dawson, Mark A, Delhommeau, F., Vannucchi, A., Kusec, R., McMullin, M.F., Vainchenker, William, Vannucchi, Alessandro M, Beer, Philip A, Chen, E., Bareford, D., LeCouédic, Jean-Pierre, Bareford, David, Harrison, C.N., Green, A.R., Green, Anthony R, Dawson, M.A.   +23 more
core   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source