Results 111 to 120 of about 79,208 (292)
Iron deficiency in JAK2 exon12 and JAK2-V617F mutated polycythemia vera [PDF]
Blood Cancer Journal, 2021 Dan Liu +18 more
openaire +3 more sources
JPGN Reports, EarlyView.Abstract Janus kinase inhibitors (JAKi) are increasingly used for refractory inflammatory bowel disease (IBD) in pediatric patients but are associated with significant dermatologic adverse effects. Acneiform eruptions have been reported in up to 30% of adults, with a greater incidence suspected in adolescents.
Tina H. Tran +5 more
wiley +1 more source
Importância da investigação da mutação JAK2V617F em pacientes com neoplasia mieloproliferativa crônica BCR/ABL negativa e sua associação com a expressão da proteína antiapoptótica survivina como marcador diagnóstico [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2011As neoplasias mieloproliferativas crônicas (NMPC) são neoplasias originadas por uma proliferação ...
Barcelos, Michelle Maccarini
core
Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice
, 2008 An acquired somatic mutation in the JAK2 gene (JAK2-V617F) is present in the majority of patients with myeloproliferative disorders (MPDs). Several phenotypic manifestations (polycythemia vera [PV], essential thrombocythemia [ET], and primary ...
Sobas, Marta A. +6 more
core +1 more source
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements
Haematologica, 2013 JAK2 fusion genes are rare but recurrent abnormalities associated with diverse, clinically heterogeneous hematologic malignancies. Here we assess the JAK1/2 inhibitor ruxolitinib as therapy for patients with JAK2-rearrangement associated ...
Andrew Chase +8 more
doaj +1 more source
Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives
JSFA reports, EarlyView.Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz +10 more
wiley +1 more source
, 2011 The genetics of classical Hodgkin lymphoma (cHL) is poorly understood. The finding of a JAK2-involving t(4;9)(q21;p24) in 1 case of cHL prompted us to characterize this translocation on a molecular level and to determine the prevalence of JAK2 ...
Chris De Wolf-Peeters +12 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Vaccarin is a naturally occurring flavonoid glycoside with cardioprotective properties; however, its involvement in myocardial ischemia–reperfusion (MI/R) injury remains poorly defined. We herein investigated whether vaccarin protects cardiomyocytes from MI/R‐induced dysfunction in vivo and in vitro and examined the associated molecular ...
Han Yang, Mi Zhou, Feng‐Cai Zhang
wiley +1 more source
Therapeutic JAK Inhibition in Idiopathic Subglottic Stenosis
The Laryngoscope, EarlyView.Three patients with idiopathic subglottic stenosis and rheumatoid arthritis began JAK inhibitor therapy, after which the mean surgical‐free interval between endoscopic dilations rose from 317 to 631 days and the annualized dilation rate fell from 1.24 to 0.38 per patient‐year. Figure 2 shows this as a per‐patient timeline.
Riley M. Larkin +5 more
wiley +1 more source
Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation
Scientific Reports, 2017 During obesity, macrophages can infiltrate metabolic tissues, and contribute to chronic low-grade inflammation, and mediate insulin resistance and diabetes.
Harsh R. Desai +16 more
doaj +1 more source