Results 111 to 120 of about 73,607 (303)

Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice

, 2008
An acquired somatic mutation in the JAK2 gene (JAK2-V617F) is present in the majority of patients with myeloproliferative disorders (MPDs). Several phenotypic manifestations (polycythemia vera [PV], essential thrombocythemia [ET], and primary ...
Sobas, Marta A., Tiedt, Ralph, Looser, Renate, Dirnhofer, Stephan, Schwaller, Jürg, Skoda, Radek C., Hao-Shen, Hui   +6 more
core   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

The molecular pathogenesis of myeloproliferative neoplasms

, 2010
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of haematological stem cellmalignancies characterised by proliferation of one or more cells of the myeloid lineage.
Jones, Amy Victoria
core  

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

JAK2 mutation and treatment of JAK2 inhibitors in Philadelphia chromosome-negative myeloproliferative neoplasms

, 2013
The Philadelphia chromosome-negative (Ph-negative) myeloproliferative neoplasms (MPNs) polycythaemia vera (PV), essential thombocythaemia (ET) and primary myelofi brosis (PMF) are clonal disorders of multipotent haematopoietic progenitors.
Hutajulu, Susanna Hilda, Kurnianda, Johan   +1 more
core   +1 more source

Causal role for JAK2 V617F in thrombosis [PDF]

, 2013
In this issue of Blood, Hobbs et al use a JAK2 V617F knock-in mouse model to interrogate the impact of JAK2 V617F on thrombosis and demonstrate altered function of megakaryocytes and platelets in the context of JAK2 V617F ...
Fleischman, Angela G, Tyner, Jeffrey W
core   +1 more source

From Basics to Benchmarks: Evaluating Sample Adequacy, PD‐L1 Expression, and Molecular Profiling in Effusion Samples of Lung Adenocarcinoma

Diagnostic Cytopathology, EarlyView.
ABSTRACT Introduction Lung adenocarcinoma commonly causes malignant pleural effusion (MPE), a condition with poor prognosis and limited treatment options. Pleural effusion specimens offer a minimally invasive source for diagnosis and molecular testing.
Harpreet Virk, Claire Michael, Keri Ann Pfeil, Navid Sadri, Omid Savari, Aparna Harbhajanka   +5 more
wiley   +1 more source

The 'GGCC' haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation-positive polycythemia vera.

, 2009
Findings of this study provide evidence that the increased susceptibility to somatic mutagenesis exhibited by the JAK2 GGCC haplotype is not restricted to JAK2-V617F, but also includes the less frequent but more diverse JAK2 exon 12 ...
Cazzola M, Ay C, Pietra D, Lippert E, Gisslinger H, Reading NS, Skoda RC, Prchal JT, PASSAMONTI, FRANCESCO, Kralovics R., Girodon F, Vannucchi A, CAZZOLA, MARIO, Li S, Pabinger I, Olcaydu D, Looser R, Carillo S   +17 more
core   +1 more source

Nuclear JAK2 [PDF]

Blood, 2011
Mark A, Dawson, Andrew J, Bannister, Lindsay, Saunders, Omar-Abdel, Wahab, Fan, Liu, Stephen D, Nimer, Ross L, Levine, Berthold, Göttgens, Tony, Kouzarides, Anthony R, Green   +9 more
openaire   +2 more sources

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source