Results 261 to 270 of about 79,208 (292)

Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations

Blood, 2008
AbstractWe studied the lineage distribution of JAK2 mutations in peripheral blood of 8 polycythemia vera (PV) patients with exon 12 mutations and in 21 PV patients with JAK2-V617F. Using a quantitative allele discrimination assay, we detected exon 12 mutations in purified granulocytes, monocytes, and platelets of 8 patients studied, but lymphoid cells ...
Li, Sai, Kralovics, Robert, De Libero, Gennaro, Theocharides, Alexandre, Gisslinger, Heinz, Skoda, Radek C.   +5 more
openaire   +4 more sources

Roles of germline JAK2 activation mutation JAK2 V625F in the pathology of myeloproliferative neoplasms

International Journal of Biological Macromolecules, 2018
Janus tyrosine kinase 2 (JAK2) mediates downstream signaling of cytokine receptors in all hematological lineages, constitutively active somatic JAK2 mutations play key roles in the pathology of myeloproliferative neoplasms (MPNs). Recently, germline JAK2 mutations are also associated with triple-negative MPNs.
Qing-Yun, Wu, Meng-Meng, Ma, Lin, Fu, Yuan-Yuan, Zhu, Yang, Liu, Jiang, Cao, Ping, Zhou, Zhen-Yu, Li, Ling-Yu, Zeng, Feng, Li, Xiao-Yun, Wang, Kai-Lin, Xu   +11 more
openaire   +2 more sources

Effects of CYT387, a Potent Novel JAK2 Inhibitor on JAK2-V617F Induced MPD

Blood, 2008
Abstract Background: The V617F mutation of JAK2 (JAK2-V617F) is present in almost all patients with polycythemia vera (PV), and approximately 50% of patients with essential thrombocythemia and idiopathic myelofibrosis. JAK2-V617F leads to constitutive activation of the JAK2 kinase, causing cytokine independent growth in cell lines and ...
Bumm, T., Tyner, J. W., Deininger, J., Loriaux, M., VanDyke, J., Druker, B. J., Burns, C. J., Fantino, E., Deininger, M. W. N.   +8 more
openaire   +2 more sources

?????????????? V617F ???????? jak2 ???? ??????????????????????-???????????????????? ???????????? ?? ???????????? ???? ???????????????? ?????????????????????????????????????? ????????????????????????

2021
V617F mutation jak2 gene is an important diagnostic criterion for the diagnosis of chronic myeloproliferative disorders. The method of detection using RT-PCR and direct sequencing was propoused.
openaire   +1 more source

[JAK2, CALR].

Rinsho byori. The Japanese journal of clinical pathology, 2019
Representative diseases of BCR/ABL-negative myeloproliferative neoplasms (MPN) are polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (PMF). It was reported in 2005 that there is a common genetic mutation in Exon 14 of the JAK2 gene in MPN cases.
openaire   +1 more source

???????????????????????? ???????????????? ?????????????????????????? ?????????????????????? ???????????????????? ?????????????????????? ?? ?????????????????? ?????????????????????????? ???? ???? ??????????????? ???? ?????????????????? ?????????????? JAK2 V617F

2018
????????: ?????????????????????? ???????????????? ?????????????????????????? ?????????? ???????????????????? ?????????????????????? (????) ???? ?????????????????? ?????????????????????????? (????), ???????????? ???? ??????????????? ?? ?????????????????? ?????????????? JAK2 V617F, ???????????????????? ???????????????????? ???? ??????????????????????????
openaire   +1 more source

???????????????? ????????-?????????????? ?????? ?????????????????? ?????????????? V617F ???????? jak2 ?? ???????????? ???? ???????????????? ?????????????????????????????????????? ????????????????????????

2011
?????????????? V617F ???????? jak2 ???????????????? ???????????? ?????????????????????????????? ?????????????????? ?????? ?????????????????????? ???????????????????????????????????????? ????????????????????????. ???????????????????? ????????-?????????????? ?????? ?????????????????? ?????????????? ?? ?????????????? ???????????? ??????????????-???????????
openaire   +1 more source

BRD4-JAK2 inhibitors

2021
SCHÖNBRUNN ERNST, LAWRENCE NICHOLAS J, LAWRENCE HARSHANI R, REUTHER GARY   +3 more
openaire   +4 more sources

Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria

Cell, 2023
Jonathan Bohlen, Harri Saxén, Lucia Erazo   +2 more
exaly  

Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation

Cells, 2019
Caroline Perner, Florian H Heidel, Thomas Ernst   +2 more
exaly