Results 41 to 50 of about 4,524 (132)

JAK2V617F Mutation in Ischemic Stroke: Bridging Hematology and Stroke Neurology

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Recent evidence suggests the JAK2V617F mutation may confer an elevated risk of ischemic stroke, likely mediated by systemic inflammation, abnormal cell activation, and endothelial dysfunction.
Marie H. Kristiansen, Lasse Kjær, Vibe Skov, Morten K. Larsen, Christina Ellervik, Claus H. Nielsen, Hans C. Hasselbalch, Troels Wienecke   +7 more
doaj   +1 more source

Loss-of-function polymorphism in IL6R reduces risk of JAK2V617F somatic mutation and myeloproliferative neoplasm: A Mendelian randomization study

EClinicalMedicine, 2020
Background: Whether inflammation is independently associated with development of JAK2V617F mutation and myeloproliferative neoplasm is not clear. We tested the hypothesis that a loss-of-function polymorphism in IL6R (marked by rs4537545) reduces risk of ...
Kasper Mønsted Pedersen, Yunus Çolak, Christina Ellervik, Hans Carl Hasselbalch, Stig Egil Bojesen, Børge Grønne Nordestgaard   +5 more
doaj   +1 more source

Dissecting Bone Marrow Fibrosis in Philadelphia‐Negative Myeloproliferative Neoplasms: Multiple Roads Lead to Rome

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Philadelphia‐negative myeloproliferative neoplasms (MPN), a spectrum of blood malignancies characterized by uncontrolled myeloid proliferation, persist as a key challenge in onco‐hematology due to their intricate molecular background, heterogeneous clinical phenotypes, and variable prognoses.
Mariagiovanna Ballato, Vincenzo Fiorentino, Gabriele Ricciardi, Pietro Tralongo, Emanuela Germanà, Alessandro Allegra, Fabio Stagno, Guido Fadda, Maurizio Martini   +8 more
wiley   +1 more source

The Germline SH2B3rs111340708 Splicing Variant Drives Intron Retention and Protein Instability by Impacting Clinical Outcomes in Core Binding Factor AML

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT The SH2B3 gene, also known as LNK, encodes an adaptor protein that negatively regulates key hematopoietic signaling pathways, including JAK–STAT, MAPK, and PI3K/AKT, thereby maintaining hematopoietic homeostasis. SH2B3 interacts with major signaling regulators such as JAK2, MPL, FLT3, and KIT. Loss‐of‐function alterations have been reported in
Marta Rachele Stefanucci, Livia Leuzzi, Linda Montavoci, Davide Paolo Bernasconi, Luca Cimaschi, Alessandra Trojani, Anna Caretti, Lorenzo Del Castello, Roberto Cairoli, Alessandro Beghini   +9 more
wiley   +1 more source

Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha

Journal of Hematology & Oncology, 2019
Background Interferon alpha (IFNa) monotherapy is recommended as the standard therapy in polycythemia vera (PV) but not in chronic myeloid leukemia (CML). Here, we investigated the mechanisms of IFNa efficacy in JAK2V617F- vs.
Claudia Schubert, Manuel Allhoff, Stefan Tillmann, Tiago Maié, Ivan G. Costa, Daniel B. Lipka, Mirle Schemionek, Kristina Feldberg, Julian Baumeister, Tim H. Brümmendorf, Nicolas Chatain, Steffen Koschmieder   +11 more
doaj   +1 more source

TET2 as a Context‐Dependent Epigenetic Integrator in Clonal Hematopoiesis, Inflammation, Cancer, and Immunotherapy

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Ten‐Eleven Translocation 2 (TET2) is an Fe(II)‐ and α‐ketoglutarate‐dependent dioxygenase that initiates active DNA demethylation by oxidizing 5‐methylcytosine (5mC). Beyond this enzymatic role, TET2 links DNA methylation dynamics with chromatin regulation, cellular metabolism, immune‐cell identity, and treatment response in a context ...
XiaoJie Liu, Jiangchen Liu, Liu Feng, Dan Xu, Xianling Wei, Dekuai Tong   +5 more
wiley   +1 more source

Development of a highly sensitive method for detection of JAK2V617F

Journal of Hematology & Oncology, 2011
Background Ph- myeloproliferative neoplasms (MPNs) represent a heterogeneous group of chronic diseases characterized by increased expansion of hematopoietic cells of the myeloid lineage.
Gao Rufei, Zhao Anna H, Zhao Zhizhuang J
doaj   +1 more source

From Basics to Benchmarks: Evaluating Sample Adequacy, PD‐L1 Expression, and Molecular Profiling in Effusion Samples of Lung Adenocarcinoma

Diagnostic Cytopathology, Volume 54, Issue 8, Page 547-555, August 2026.
ABSTRACT Introduction Lung adenocarcinoma commonly causes malignant pleural effusion (MPE), a condition with poor prognosis and limited treatment options. Pleural effusion specimens offer a minimally invasive source for diagnosis and molecular testing.
Harpreet Virk, Claire Michael, Keri Ann Pfeil, Navid Sadri, Omid Savari, Aparna Harbhajanka   +5 more
wiley   +1 more source

Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasms

Blood Cancer Journal
Classical myeloproliferative neoplasms (MPNs) are characterized by the proliferation of myeloid cells and the risk of transformation into myelofibrosis or acute myeloid leukemia (AML) and TP53 mutations in MPN patients are linked to AML.
Panhong Gou, Duanya Liu, Saravanan Ganesan, Evelyne Lauret, Nabih Maslah, Veronique Parietti, Wenchao Zhang, Véronique Meignin, Jean-Jacques Kiladjian, Bruno Cassinat, Stephane Giraudier   +10 more
doaj   +1 more source

Extent of hematopoietic involvement by TET2 mutations in JAK2V617F polycythemia vera

Haematologica, 2011
TET2 mutations are found in polycythemia vera and it was initially reported that there is a greater TET2 mutational burden than JAK2V617F in polycythemia vera stem cells and that TET2 mutations precede JAK2V617F.
Sabina I. Swierczek, Donghoon Yoon, Christine Bellanné-Chantelot, Soo Jin Kim, Cécile Saint-Martin, Francois Delhommeau, Albert Najman, Josef T. Prchal   +7 more
doaj   +1 more source