Results 61 to 70 of about 4,524 (132)

A blockade of leukotriene-mediated Alox5 function provides a new strategy for the treatment of JAK2V617F-induced polycythemia vera

Haematologica
Polycythemia vera (PV) is a hematopoietic stem cell disorder characterized by JAK2V617F, a mutation that gives rise to erythrocytosis. Our previous studies have shown that arachidonate 5-lipoxygenase (Alox5) is a critical driver in PV and the inhibition
Yi Shan, Ngoc DeSouza, Noah Littman, Qiang Qiu, Kathy Nguyen, Yehua Yu, Golam Mohi, Shaoguang Li   +7 more
doaj   +1 more source

Sex differences in the JAK2V617F allele burden in chronic myeloproliferative disorders

Haematologica, 2010
Background The JAK2V617F allele burden is a variable measure, determined by the frequency of mitotic recombination events and the expansion of JAK2V617F clones.
Brady L. Stein, Donna M. Williams, Nae-Yuh Wang, Ophelia Rogers, Mary Ann Isaacs, Naveen Pemmaraju, Jerry L. Spivak, Alison R. Moliterno   +7 more
doaj   +1 more source

NEOPLASIAS MIELOPROLIFERATIVAS COM COEXISTÊNCIA DA TRANSLOCAÇÃO BCR-ABL1 P190 E MUTAÇÃO ATIVADORA DA TIROSINA QUINASE JAK2V617F EM AMOSTRAS LABORATORIAIS

Hematology, Transfusion and Cell Therapy
Introdução: A classificação de neoplasias mieloproliferativas surgem de células-tronco hematopoiéticas com sinalização de tirosina quinase alterada somaticamente.
PY Nishimura, AA Gomes, PV Macedo, D Moratori, LGV Nova, KT Igari, LMR Janini, CAD Santos   +7 more
doaj   +1 more source

Polycythemia Vera: Literature Review and Own Data

Клиническая онкогематология, 2015
Background & Aims. Polycythemia vera (PV) refers to a group of classic Ph-negative myeloproliferative neoplasms characterized by panmyelosis, pancytosis, high risk of thrombotic and hemorrhagic complications, poor quality of life due to symptoms of tumor
Irina Nikolaevna Subortseva, T. I. Kolosheinova, E. I. Pustovaya, E. K. Egorova, A. M. Kovrigina, Yu. V. Pliskunova, T. V. Makarik, A. O. Abdullaev, A. L. Melikyan   +8 more
doaj   +1 more source

This Is Not a Myeloproliferative Neoplasm…

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
Stephanie Juané Kennedy
wiley   +1 more source

A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression.

PLoS ONE, 2019
Aberrant activation of the JAK/STAT pathway is thought to be the critical event in the pathogenesis of the chronic myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia and primary myelofibrosis.
Emilie A Chapeau, Emeline Mandon, Jason Gill, Vincent Romanet, Nicolas Ebel, Violetta Powajbo, Rita Andraos-Rey, Zhiyan Qian, Miltos Kininis, Sabine Zumstein-Mecker, Moriko Ito, Nancy E Hynes, Ralph Tiedt, Francesco Hofmann, Leonid Eshkind, Ernesto Bockamp, Bernd Kinzel, Matthias Mueller, Masato Murakami, Fabienne Baffert, Thomas Radimerski   +20 more
doaj   +1 more source

Polycythemia vera: Correlation of JAK2V617F mutation with clinicohematologic characteristics. A single centre experience.

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Introduction Janus kinase2 (JAK2) V617F mutation in myeloid cells has been reported from the majority of patients with Polycythemia vera (PV). Materials & Methods A cross sectional study was conducted to review clinical records of 93 cases of ...
Deepti Mutreja, Sudha Sazawal, Sunita Chhikara, Manoranjan Mahapatra, Pravas Mishra, Tulika Seth, Renu Saxena   +6 more
doaj  

Translocation t(3;12)(q26;q21) In Jak2V617F Point Mutation Negative Chronic Idiopathic Myelofibrosis: A Case Report

Balkan Journal of Medical Genetics, 2014
The myeloproliferative diseases (MPDs) or myelo-proliferative neoplasms (MPNs) are a group of diseases of the bone marrow in which excess cells are produced. Chronic idiopathic myelofibrosis (CIMF) is a stem cell defect characterized by splenomegaly with
S. Mešanović, H. Šahović, M. Perić
doaj   +1 more source

JAK2V617F Allele Burden Measurement in Peripheral Blood of Iranian Patients with Myeloproliferative Neoplasms and Effect of Hydroxyurea on JAK2V617F Allele Burden

International Journal of Hematology-Oncology and Stem Cell Research, 2016
Background: Myeloproliferative neoplasms (MPNs) are clonal malignant diseases that represent a group of conditions including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF).
Shirin Ferdowsi, Seyed H Ghaffari, Naser Amirizadeh, Azita Azarkeivan, Kamran Atarodi, Mohammad Faranoush, Gholamreza Toogeh, Reza Shirkoohi, Mohammad Vaezi, Mahtab Maghsoodlu, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Hosein Teimori Naghadeh   +12 more
doaj  

Characterization of JAK2V617F and the JAK2 46/1 germline haplotype in myeloproliferative neoplasms in a Saudi Arabian cohort: a case-based analysis. [PDF]

Front Oncol
Mutrib N, Alqarni S, Peer-Zada AA, Samman M, Fatima S, Arjumand S, Aldahshan H, Alharbi KK, AlRashed MM.   +8 more
europepmc   +1 more source