Results 91 to 100 of about 89,537 (296)
Exploring downstream pathways of aberrantly activated kinases for targeted leukemia therapy [PDF]
, 2008 Genetic alterations resulting in uncontrolled protein tyrosine kinases (PTKs) activity are frequently found in leukemia and in human solid cancers. Although the development of small molecule kinase inhibitors has revolutionized therapy for PTKinduced ...
Gasser, Christelle
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations.
, 2011 The discovery of JAK2V617F has rejuvenated interest in Janus kinase (JAK)-signal transducer and activator of transcription (STAT), both as an oncogenic pathway and a drug target in BCR-ABL1-negative myeloproliferative neoplasms (MPN).
Vannucchi AM +5 more
core +1 more source
Efficacy of JAK inhibitors in Crohn’s Disease [PDF]
Journal of Crohn's and Colitis, 2019 Abstract Inhibition of Janus kinases [JAKs] in Crohn’s disease [CD] patients has shown conflicting results in clinical trials. Tofacitinib, a pan-JAK inhibitor, showed efficacy in ulcerative colitis [UC] and has been approved for the treatment of patients with moderate to severe UC.
openaire +3 more sources
, 2022 Phase III MANIFEST-2: pelabresib + ruxolitinib vs placebo + ruxolitinib in JAK inhibitor treatment-naive myelofibrosis ...
Timothy Devos (13810354) +24 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
, 2015 Summary Although clinically tested JAK inhibitors offer significant benefit to myeloproliferative neoplasm (MPN) patients, they do not induce molecular remissions.
Levine, Ross L +22 more
core
JAK2 mutations display resistance to JAK Inhibitor-I.
, 2012 BaF3 hematopoietic cells expressing the construct indicated were treated for 48 hours in cytokine-free medium containing two-fold increasing concentrations of JAK Inhibitor-I. Cell viability was determined using the XTT assay.
Manprit Chohan (141676) +6 more
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Tofacitinib for Prurigo Nodularis: A Case Report
Clinical, Cosmetic and Investigational Dermatology, 2022 Changlan Peng,1 Chunxiao Li,2 Yingying Zhou,1 Qiuyue Wang,1 Ping Xie,1 Tianhao Li,2,* Pingsheng Hao2,* 1Department of Dermatology, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Department of Dermatology,
Peng C +6 more
doaj