Results 111 to 120 of about 89,537 (296)
Oncostatin M-driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis
Inflammation and RegenerationBackground Recent single-cell RNA sequencing (scRNA-seq) analysis revealed the functional heterogeneity and pathogenic cell subsets in immune cells, synovial fibroblasts and bone cells in rheumatoid arthritis (RA).
Nam Cong-Nhat Huynh +15 more
doaj +1 more source
Effects of the novel aurora kinase/JAK inhibitor, AT9283 and imatinib on Philadelphia positive cells in vitro [PDF]
, 2012 Lyons, John +4 more
core +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Efficacy of Oral Tofacitinib in Moderate-to-Severe Pediatric Atopic Dermatitis: A Case Series
Indian Journal of Paediatric DermatologyAtopic dermatitis (AD) is a chronic skin disease most commonly affecting children. The pathophysiology is thought to be influenced by the JAK-STAT signalling system. There are very few studies showing the efficacy of JAK-STAT inhibitors in AD.
Archita Bhattacharya +5 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
RMD OpenObjectives This study aimed to evaluate the risk of tuberculosis associated with the use of Janus kinase (JAK) inhibitors or biological disease-modifying antirheumatic drugs (bDMARDs) in patients diagnosed with rheumatoid arthritis (RA) in South Korea ...
Jin-Won Kwon +3 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Jak2 V617F G935R is resistant to JAK Inhibitor-I.
, 2012 BaF3 hematopoietic cells expressing the construct indicated were treated for 48 hours in RPMI medium plus 0.1 units/mL EPO containing two-fold increasing concentrations of JAK Inhibitor-I. Post-treatment cell viability was determined using the XTT assay.
Manprit Chohan (141676) +6 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Treatment of Discoid Lupus Erythematosus with Upadacitinib: A Case Report
Clinical, Cosmetic and Investigational Dermatology, 2023 Wenting Hu, Si Zhang, Cuihong Lian Department of Dermatology, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, People’s Republic of ChinaCorrespondence: Cuihong Lian, Department of Dermatology, Shenzhen Second People’s Hospital, No.
Hu W, Zhang S, Lian C
doaj