Results 111 to 120 of about 985,459 (298)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Efficacy and Tolerability of Brevilin-A, a Natural JAK Inhibitor, in Pediatric Alopecia Areata: A Case Series [PDF]

Enrico Matteini,1,* Laura Diluvio,1,* Sara Lambiase,1 Arnaldo Cioni,1 Ruslana Gaeta Shumak,1 Gaetana Costanza,2 Caterina Lanna,1 Giacomo Caldarola,3,4 Luca Bianchi,1 Elena Campione1 1Dermatology Unit, Department of Systems Medicine, University of
Lambiase S, Caldarola G, Costanza G, Bianchi L, Diluvio L, Cioni A, Matteini E, Gaeta Shumak R, Lanna C, Campione E   +9 more
core  

Inhibitor-based affinity probes for the investigation of JAK signaling pathways

, 2015
Hoefener M, Pachl F, Kuster B, Sewald N. Inhibitor-based affinity probes for the investigation of JAK signaling pathways. PROTEOMICS. 2015;15(17):3066-3074.The Janus Kinase (JAK) signaling pathway plays a key role for many cellular processes and has ...
Pachl, Fiona, Hoefener, Michael, Fiona Pachl, Norbert Sewald, Bernhard Kuster, Michael Höfener, Sewald, Norbert ; https://orcid.org/, Kuster, Bernhard   +7 more
core   +1 more source

Refractory granuloma faciale successfully treated with adjunct topical JAK inhibitor

JAAD Case Reports, 2023
Ailynna Chen, MPH, Christina L. Harview, MD, Sydney E. Rand, BSBA, Jessica L. Harms, MD   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

JAK2 mutations display resistance to JAK Inhibitor-I.

, 2012
BaF3 hematopoietic cells expressing the construct indicated were treated for 48 hours in cytokine-free medium containing two-fold increasing concentrations of JAK Inhibitor-I. Cell viability was determined using the XTT assay.
Manprit Chohan (141676), David R. Rose (141686), Dwayne L. Barber (141689), Natasha Matthew (141679), Michael R. Marit (141673), Kai Huang (3983), Douglas A. Kuntz (141682)   +6 more
core   +1 more source

Therapeutic Potential of Janus Kinase Inhibitors for the Management of Interstitial Lung Disease

Drug Design, Development and Therapy, 2022
Rongxiu Huo,1,* Qianyu Guo,1,* Junping Hu,2 Na Li,1 Rui Gao,1 Liangyu Mi,1 Zhaoliang Zhang,1 Hechao Liu,1 Zhiying Guo,1 Hanxi Zhao,3 Liyun Zhang,1 Ke Xu1 1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of ...
Huo R, Guo Q, Hu J, Li N, Gao R, Mi L, Zhang Z, Liu H, Guo Z, Zhao H, Zhang L, Xu K   +11 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

NVP-CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms

, 2015
Summary Although clinically tested JAK inhibitors offer significant benefit to myeloproliferative neoplasm (MPN) patients, they do not induce molecular remissions.
Levine, Ross L, Murakami, Masato, Kleppe , Maria, Doelemeyer, Arno, Baffert, Fabienne, Sellers, William, Guryanova, Olga, Rubert, Joelle, Hofmann, Francesco, Radimerski, Thomas, Gaul, Christoph, Romanet, Vincent, Rapaport, Franck, Ebel, Nicolas, Dammassa, Ernesta, Meyer, Sara C, Andraos-Rey, Rita, Spitzer, Barbara, Zender, Michael, Keller, Matthew D, McKenney, Anna-Sophia, Mandon, Emeline, Koppikar, Priya   +22 more
core