Results 121 to 130 of about 56,162 (258)

Tofacitinib for Pityriasis Rubra Pilaris: A Case Report

Clinical, Cosmetic and Investigational Dermatology
Hongyan Tan, Bin Zhang, Xiawei Kang, Lvyao Wang, Xiao Qiu, Xiangyu Hu Department of Dermatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400011, People’s Republic of ChinaCorrespondence: Xiangyu Hu, Email 369930758@qq.comPurpose ...
Tan H, Zhang B, Kang X, Wang L, Qiu X, Hu X   +5 more
doaj  

JAK Inhibitor Clinical Response in Polyarthritis: Case Report

Acta Clinica Croatica, 2015
The heterogeneity of rheumatoid arthritis (RA) presentation and molecular signature of RA subclasses in patients with early changes of small peripheral joints still remains a challenging problem.
Asja Stipić-Marković, Iva Ferček, Marta Čubela, Marinko Artuković, Ksenija Maštrović Radončič, Liborija Lugović-Mihić   +5 more
doaj  

Therapeutic Potential of Janus Kinase Inhibitors for the Management of Interstitial Lung Disease

Drug Design, Development and Therapy, 2022
Rongxiu Huo,1,* Qianyu Guo,1,* Junping Hu,2 Na Li,1 Rui Gao,1 Liangyu Mi,1 Zhaoliang Zhang,1 Hechao Liu,1 Zhiying Guo,1 Hanxi Zhao,3 Liyun Zhang,1 Ke Xu1 1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of ...
Huo R, Guo Q, Hu J, Li N, Gao R, Mi L, Zhang Z, Liu H, Guo Z, Zhao H, Zhang L, Xu K   +11 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Efficacy of Oral Tofacitinib in Moderate-to-Severe Pediatric Atopic Dermatitis: A Case Series

Indian Journal of Paediatric Dermatology
Atopic dermatitis (AD) is a chronic skin disease most commonly affecting children. The pathophysiology is thought to be influenced by the JAK-STAT signalling system. There are very few studies showing the efficacy of JAK-STAT inhibitors in AD.
Archita Bhattacharya, Abhipsa Samal, Bikash Ranjan Kar, Manoj Kumar Nayak, Nibedita Dixit, Liza Mohapatra   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Comparison of active tuberculosis occurrence associated with Janus kinase inhibitors and biological DMARDs in rheumatoid arthritis

RMD Open
Objectives This study aimed to evaluate the risk of tuberculosis associated with the use of Janus kinase (JAK) inhibitors or biological disease-modifying antirheumatic drugs (bDMARDs) in patients diagnosed with rheumatoid arthritis (RA) in South Korea ...
Jin-Won Kwon, Yun-Kyoung Song, Jaehee Lee, Junwoo Jo   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source