Results 101 to 110 of about 985,459 (298)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

JAK-STAT6 inhibitors decrease IL-13-induced eotaxin-3 expression in esophageal epithelial cells.

, 2016
IL-13-induced (a) STAT6 phosphorylation, (b) eotaxin-3 mRNA, and (c) eotaxin-3 protein expression are decreased in esophageal epithelial cells, following treatment with JAK-STAT6 inhibitors (AS1517499 and leflunomide).
Xi Zhang (83736), Chunhua Yu (297731), Xiaofang Huo (297729), Stuart J. Spechler (252421), Qiuyang Zhang (297733), Rhonda F. Souza (182856), Kathleen S. Wilson (2839109), David H. Wang (297736), Jason Y. Park (591767), Edaire Cheng (297727)   +9 more
core   +1 more source

Efficacy of JAK Inhibitors versus DMARDs in the Treatment of Polymyalgia Rheumatica in China

International Journal of General Medicine, 2023
Juanfang Gu,1,2 Mingfeng Yang,1,2 Bin Zhang,1,2 Hongzhi Wang1,2 1Department of Rheumatology and Immunology, The Affiliated Hospital of Jiaxing University (The First Hospital of Jiaxing), Jiaxing, Zhejiang, 314300, People’s Republic of China; 2Jiaxing Key
Gu J, Yang M, Zhang B, Wang H
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A Case of Refractory Panuveitis with Coexisting Spondyloarthritis Successfully Treated with Tofacitinib

Case Reports in Ophthalmology
Introduction: Non-infectious uveitis is commonly treated with corticosteroids, immunosuppressants, and, recently, TNF inhibitors. However, some patients do not achieve adequate control of uveitis with these drugs.
Ayano Wakabayashi, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Keitaro Hase, Kayo Suzuki, Yo Ogino, Miki Hiraoka, Nobuyoshi Kitaichi, Shuhei Takeyama, Tatsuya Atsumi, Susumu Ishida   +11 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A JAK gátlás lehetőségei az arthritisek kezelésében

, 2015
A JAK-inhibitorok klinikai hatékonyságának és biztonságosságának irodalmi összefoglalója rheumatoid arthritis megbetegedésekben, fókuszpontban a rheumatoid arthritis terápiájában elsőként elfogadott JAK-gátló, a tofacitinib (Xeljanz) készítménnyel.
Hamar, Attila
core  

Funktionelle Charakterisierung von Mitgliedern des MicroRNA-17-92-Clusters im Blutgefäßsystem [PDF]

, 2011
Almost two decades ago, microRNAs were discovered as novel posttranscriptional regulators of gene expression. Since then, research efforts have uncovered their involvement in the control of various cellular processes including migration, proliferation ...
Döbele, Carmen
core  

Jak się robi Edutech w AGH?

, 2022
Dowiesz się dzięki Ewelinie Zalot, jak możesz wykorzystać aplikację GeoGebra, Apowersoft oraz LearningApps to narzędzia, które pokaże Aleksandra Wilk, jak nagrywać i montować filmiki edukacyjne w DaVinciResolve nauczy nas Karolina Kaczmarska ...
Kaczmarska, Karolina, Wilk, Aleksandra, Zalot, Ewelina   +2 more
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source