Results 201 to 210 of about 72,228 (243)

An exhaustive examination of the research progress in identifying potential JAK inhibitors from natural products: a comprehensive overview. [PDF]

Chin Med
Yang W, Lu J, Luo P, Xu Z, Yan H, Yang B, He Q, Zhou J, Yang X.   +8 more
europepmc   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

The Role of JAK Inhibitors in Pediatric Lichen Sclerosus et Atrophicus: A Case Report. [PDF]

Cureus
Sharma S, Bandhade A, Singh MK, Koshley V, Gongale SP.   +4 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

JAK Inhibitors in African American Patients With Alopecia Areata: A Case Series. [PDF]

Int J Dermatol
Mukenge MM, Rao S, Obeime I, Larrondo J, Palmer V, McMichael A.   +5 more
europepmc   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

The Dual-Edged Sword: Risks and Benefits of JAK Inhibitors in Infections. [PDF]

Pathogens
Jarneborn A, Kopparapu PK, Jin T.
europepmc   +1 more source

JAK inhibitors remove innate immune barriers facilitating viral propagation. [PDF]

NAR Mol Med
Ravlo E, Ianevski A, Skipperstøen MN, Lysvand H, Schjølberg JO, Solheim O, Wang W, Kissova M, Vestvik M, Vapalahti O, Smura T, Vauhkonen H, Oksenych V, Weber F, Strand M, Evander M, Malmring JF, Afset JE, Bjørås M, Kainov DE.   +19 more
europepmc   +1 more source

Efficacy and Safety of JAK Inhibitors in the Management of Vitiligo: A Systematic Review and Meta-analysis. [PDF]

Dermatol Ther (Heidelb)
Mohammed AA, Lengyel AS, Meznerics FA, Szondy I, Walter A, Szabó B, Pál D, Bojtor A, Bánvölgyi A, Kiss N, Hegyi P, Kemény LV, Kurgyis Z.   +12 more
europepmc   +1 more source

Real-world Experience with JAK Inhibitors and Dupilumab in Dystrophic Epidermolysis Bullosa: A Case Report and Literature Review. [PDF]

Acta Derm Venereol
Ling S, Dou X.
europepmc   +1 more source