Results 251 to 260 of about 80,577 (303)
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Albert Wolkerstorfer +10 more
wiley +1 more source
Janus kinase inhibitors in pulmonary and extra-pulmonary sarcoidosis: A case series and a systematic review of the literature. [PDF]
Sarcoidosis Vasc Diffuse Lung DisQuaggetto M +7 more
europepmc +1 more source
Intraocular infections following biologicals and Janus Kinase inhibitors. [PDF]
Indian J OphthalmolDutta Majumder P, Kene RD.
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Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F [PDF]
Journal of Cellular and Molecular Medicine, 2013 peer reviewedThe Janus kinase 2 mutant V617F occurs with high frequency in myeloproliferative neoplasms. Further mutations affecting the Janus kinase family have been discovered mostly in leukaemias and in myeloproliferative neoplasms.
Catherine Rolvering +2 more
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Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis
Cochrane Database of Systematic Reviews, 2015Myelofibrosis is a bone marrow disorder characterized by excessive production of reticulin and collagen fiber deposition caused by hematological and non-hematological disorders. The prognosis of myelofibrosis is poor and treatment is mainly palliative.
Arturo J, Martí-Carvajal +2 more
openaire +4 more sources
Negative Regulation of Janus Kinases
Cell Biochemistry and Biophysics, 2001The precise regulation of both the magnitude and the duration of Janus kinase (JAK) catalytic activity is essential for the cytokine orchestration of many biological processes, and the dysregulation of JAK activity has pathological implications.
R J, Duhé, L H, Wang, W L, Farrar
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Malignancy and Janus Kinase Inhibition
Rheumatic Disease Clinics of North America, 2017The use of biologics such as anti-tumor necrosis factor and oral Janus kinase inhibitors have revolutionized the treatment of rheumatoid arthritis (RA). The risk of malignancies such as lymphomas, lung cancer, and nonmelanoma skin cancers (NMSCs) is greater in patients with RA compared with the general population.
Padmapriya, Sivaraman, Stanley B, Cohen
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The many faces of Janus kinase
Biochemical Pharmacology, 2012Janus kinases have proved to be essential for many immunological processes but there is growing evidence that they also play a critical role in pathogenesis of many diseases including inflammatory diseases and cancer where they promote multiple steps of tumorigenesis.
Matthew M, Seavey, Pawel, Dobrzanski
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Seminars in Oncology, 2009
The chronic myeloproliferative neoplasms (MPNs) polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (MF) are commonly associated with mutations in the Janus kinase gene JAK2. A hallmark of PV is an abundance of red blood cells; ET, too many platelets; and MF, accumulation of neutrophils and monocytes accompanied by bone ...
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The chronic myeloproliferative neoplasms (MPNs) polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (MF) are commonly associated with mutations in the Janus kinase gene JAK2. A hallmark of PV is an abundance of red blood cells; ET, too many platelets; and MF, accumulation of neutrophils and monocytes accompanied by bone ...
openaire +2 more sources
Janus kinases in cytokine signalling
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1996Abstract Hematopoiesis is largely regulated by the binding of cytokines to receptors of the cytokine receptor superfamily. Although lacking catalytic domains, members of the cytokine receptor superfamily mediate ligand dependent activation of tyrosine phosphorylation which is critical for all receptor functions.
James N. Ihle, Christopher John Marshall
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