Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2 [PDF]
Journal of Translational Medicine, 2022 Background JAK1 and JAK2 have been implicated in fibrosis and cancer as a fibroblast-related marker; however, their role in liver fibrosis has not been elucidated.
Zhenghui Song +8 more
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IL-17A Damages the Blood–Retinal Barrier through Activating the Janus Kinase 1 Pathway [PDF]
Biomedicines, 2021 Blood–retinal barrier (BRB) dysfunction underlies macular oedema in many sight-threatening conditions, including diabetic macular oedema, neovascular age-related macular degeneration and uveoretinitis.
Eimear M. Byrne +5 more
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Immunohistochemistry of Janus Kinase 1 (JAK1) Expression in Vitiligo [PDF]
Journal of Pathology and Translational Medicine, 2018 Background Vitiligo is a chronic autoimmune disease in which the destruction of melanocytes causes white spots on the affected skin. Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals ...
Asmaa Gaber Abdou +3 more
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The Janus kinase 1 is critical for pancreatic cancer initiation and progression [PDF]
Cell ReportsSummary: Interleukin-6 (IL-6)-class inflammatory cytokines signal through the Janus tyrosine kinase (JAK)/signal transducer and activator of transcription (STAT) pathway and promote the development of pancreatic ductal adenocarcinoma (PDAC); however, the
Hridaya Shrestha +13 more
doaj +2 more sources
Successful Treatment of Severe Nail Lichen Planus with Janus Kinase 1 Inhibitor Abrocitinib [PDF]
Clinical, Cosmetic and Investigational DermatologyYingzhi Luo,1,* Jian Wu,2,* Xingyun Zhao,1,* Ping Yang,1 Yunmi Qiu,1 Liming Wu,1 Jianbo Zhong1 1Department of Dermatology, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang ...
Luo Y +6 more
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Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression [PDF]
Cell Reports, 2018 Summary: Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine signaling, tissue homeostasis, and cancer development. Using a breast cancer model that conditionally lacks Janus kinase 1, we show here that JAK1 is essential ...
Barbara L. Wehde +5 more
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Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes [PDF]
ASN Neuro, 2021 Nitric oxide (NO) is a versatile free radical that has been implicated in many biological processes (i.e., vasodilation, neurotransmission, and smooth muscle relaxation).
John D. Nowery +3 more
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Tofacitinib in the management of active psoriatic arthritis: patient selection and perspectives [PDF]
Psoriasis: Targets and Therapy, 2019 Karen Ly,1 Kristen M Beck,1 Mary P Smith,1 Ana-Maria Orbai,2 Wilson Liao11Department of Dermatology, University of California San Francisco, San Francisco, CA, USA; 2Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USACorrespondence ...
Ly K +4 more
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Successful Treatment of Nail Lichen Planus by the Janus Kinase 1 Upadacitinib and Literature Review [PDF]
Clinical, Cosmetic and Investigational DermatologyXingyun Zhao,1,* Jianbo Zhong,1,* Yanzhen Xu,2 Yingzhi Luo,1 Yunmi Qiu,1 Liming Wu,1 Ping Yang1 1Department of Dermatology, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang, People’s
Zhao X +6 more
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Selective Janus Kinase 1 Inhibition Is a Promising Therapeutic Approach for Lupus Erythematosus Skin Lesions [PDF]
Frontiers in Immunology, 2020 BackgroundCutaneous lupus erythematosus (CLE) is an interferon (IFN) -driven autoimmune skin disease characterized by an extensive cytotoxic lesional inflammation with activation of different innate immune pathways.
Tanja Fetter +5 more
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